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Displaying 20 of 27 results for "CDKL4"
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  1. Trancriptomic analysis of PKA and PKC signalling gene cascade in cultured human ovarian granulosa cells (KGN) [FSK treatments] ArrayExpress

    ID: E-GEOD-84541

    Description: in oocyte competence acquisition through protein kinase A (PKA) and protein kinase C (PKC) signalling in granulosa cells. Therefore, human-like granulosa cells (KGN) were treated with forskolin 10 μM and phorbol 12-myristate 13-acetate 0.1 μM for 24 hours in order to process a transcriptomic analysis of differentially express genes between treatment. Over 2000 genes were founded to be differentially express at cut-off fold change of 1.5 and a p-value of 0.05. Five major upstreams, EGF, TGFB1, VEGF, FGF2 and HGF were founded to play an important role in competence acquisition thought PKA and PKC signalling. Differentially expressed targeted g...

  2. Shp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice [Mouse430A_2 array] ArrayExpress

    ID: E-GEOD-50516

    Description: tion of senescence-associated β-gal (SA-β-gal), cyclin-dependent kinase inhibitor 1B (p27), p53, and histone 3 trimethylated lysine 9 (H3K9me3). Senescence induction leads to inhibition of self-renewal of tumor cells and blockage of tumor formation and growth. A signaling cascade was identified that acts downstream of Shp2 to counter senescence: Src, Focal adhesion kinase and Map kinase inhibit...

  3. Trancriptomic analysis of PKA and PKC signalling gene cascade in cultured human ovarian granulosa cells (KGN) [PMA treatments] ArrayExpress

    ID: E-GEOD-84542

    Description: in oocyte competence acquisition through protein kinase A (PKA) and protein kinase C (PKC) signalling in granulosa cells. Therefore, human-like granulosa cells (KGN) were treated with forskolin 10 μM and phorbol 12-myristate 13-acetate 0.1 μM for 24 hours in order to process a transcriptomic analysis of differentially express genes between treatment. Over 2000 genes were founded to be differentially express at cut-off fold change of 1.5 and a p-value of 0.05. Five major upstreams, EGF, TGFB1, VEGF, FGF2 and HGF were founded to play an important role in competence acquisition thought PKA and PKC signalling. Differentially expressed targeted g...

  4. Shp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice [Mouse430A_2 array] BioProject

    ID: PRJNA217933

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: tion of senescence-associated β-gal (SA-β-gal), cyclin-dependent kinase inhibitor 1B (p27), p53, and histone 3 trimethylated lysine 9 (H3K9me3). Senescence induction leads to inhibition of self-renewal of tumor cells and blockage of tumor formation and growth. A signaling cascade was identified that acts downstream of Shp2 to counter senescence: Src, Focal adhesion kinase and Map kinase inhibit...
  5. Crystal structure of the human CDKL5 kinase domain PDB

    ID: PDB:4BGQ

    Description: CYCLIN-DEPENDENT KINASE-LIKE 5 (E.C.2.7.11.22)

  6. Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance ArrayExpress

    ID: E-GEOD-35411

    Description: no further improvement during weight maintenance. Cyclin-dependent kinase inhibitor 2B (CDKN2B) and JAZF zinc finger 1 (JAZF1), associated with type 2 diabetes, were downregulated. We could also confirm the downregulation of candidates for obesity and related traits, such as tenomodulin (TNMD) and matrix metallopeptidase 9 (MMP9), with weight loss. The expression of other candidates, such as cell death-inducing DFFA-like effector A (CIDEA) and stearoyl-CoA desaturase (SCD) were upregulated during weight loss but returned to baseline levels during weight maintenance. Conclusion. Genes in the adipose tissue are differentially expressed during weight loss and weight maintenance after weight loss. Genes that show sustained regulation may be of potential interest as markers of the beneficial effects of weight loss whereas others seem to be primarily involved in the process of weight loss itself. Nine participants were prescribed ...

  7. Trancriptomic analysis of PKA and PKC signalling gene cascade in cultured human ovarian granulosa cells (KGN) [PMA treatments] BioProject

    ID: PRJNA329591

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: in oocyte competence acquisition through protein kinase A (PKA) and protein kinase C (PKC) signalling in granulosa cells. Therefore, human-like granulosa cells (KGN) were treated with forskolin 10 μM and phorbol 12-myristate 13-acetate 0.1 μM for 24 hours in order to process a transcriptomic analysis of differentially express genes between treatment. Over 2000 genes were founded to be differentially express at cut-off fold change of 1.5 and a p-value of 0.05. Five major upstreams, EGF, TGFB1, VEGF, FGF2 and HGF were founded to play an important role in competence acquisition thought PKA and PKC signalling. Differentially expressed targeted g...
  8. Trancriptomic analysis of PKA and PKC signalling gene cascade in cultured human ovarian granulosa cells (KGN) [FSK treatments] BioProject

    ID: PRJNA329592

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: in oocyte competence acquisition through protein kinase A (PKA) and protein kinase C (PKC) signalling in granulosa cells. Therefore, human-like granulosa cells (KGN) were treated with forskolin 10 μM and phorbol 12-myristate 13-acetate 0.1 μM for 24 hours in order to process a transcriptomic analysis of differentially express genes between treatment. Over 2000 genes were founded to be differentially express at cut-off fold change of 1.5 and a p-value of 0.05. Five major upstreams, EGF, TGFB1, VEGF, FGF2 and HGF were founded to play an important role in competence acquisition thought PKA and PKC signalling. Differentially expressed targeted g...
  9. Crystal structure of the human CDKL3 kinase domain PDB

    ID: PDB:3ZDU

    Description: CYCLIN-DEPENDENT KINASE-LIKE 3 (E.C.2.7.11.22)

  10. CRYSTAL STRUCTURE OF THE HUMAN CDKL1 KINASE DOMAIN PDB

    ID: PDB:4AGU

    Description: CYCLIN-DEPENDENT KINASE-LIKE 1

  11. CRYSTAL STRUCTURE OF THE HUMAN CDKL2 KINASE DOMAIN PDB

    ID: PDB:4AAA

    Description: CYCLIN-DEPENDENT KINASE-LIKE 2 (E.C.2.7.11.22)

  12. CRYSTAL STRUCTURE OF THE HUMAN CDKL2 KINASE DOMAIN WITH BOUND TCS 2312 PDB

    ID: PDB:4BBM

    Description: CYCLIN-DEPENDENT KINASE-LIKE 2 (E.C.2.7.11.22)

  13. Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance BioProject

    ID: PRJNA152805

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: no further improvement during weight maintenance. Cyclin-dependent kinase inhibitor 2B (CDKN2B) and JAZF zinc finger 1 (JAZF1), associated with type 2 diabetes, were downregulated. We could also confirm the downregulation of candidates for obesity and related traits, such as tenomodulin (TNMD) and matrix metallopeptidase 9 (MMP9), with weight loss. The expression of other candidates, such as cell death-inducing DFFA-like effector A (CIDEA) and stearoyl-CoA desaturase (SCD) were upregulated during weight loss but returned to baseline levels during weight maintenance. Conclusion. Genes in the adipose tissue are differentially expressed during weight loss and weight maintenance after weight loss. Genes that show sustained regulation may be of potential interest as markers of the beneficial effects of weight loss whereas others seem to be primarily involved in the process of weight loss itself. Overall design: Nine participants ...
  14. Krüppel-like factor 4 regulates T cell function BioProject

    ID: PRJNA132021

    Keywords: Transcriptome or Gene expression

    Access Type: download

  15. Krüppel-like factor 4 regulates T cell function ArrayExpress

    ID: E-GEOD-24880

    Description: Krüppel-like factor 4 (Klf4), a transcription factor mediating context-dependent activation or repres...

  16. Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression BioProject

    ID: PRJNA309394

    Keywords: Transcriptome or Gene expression

    Access Type: download

  17. CRYSTAL STRUCTURE OF P18-INK4C(INK6) PDB

    ID: PDB:1IHB

    Description: CYCLIN-DEPENDENT KINASE 6 INHIBITOR

  18. Shp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice [Mouse430A_2 array] OmicsDI

    ID: E-GEOD-50516

    Date Released: 03-16-2015

    Description: tion of senescence-associated β-gal (SA-β-gal), cyclin-dependent kinase inhibitor 1B (p27), p53, and histone 3 trimethylated lysine 9 (H3K9me3). Senescence induction leads to inhibition of self-renewal of tumor cells and blockage of tumor formation and growth. A signaling cascade was identified that acts downstream of Shp2 to counter senescence: Src, Focal adhesion kinase and Map kinase inhibit...

  19. THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors BioProject

    ID: PRJNA317489

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: , in particular, to THZ1, a covalent inhibitor of cyclin-dependent kinase 7 (CDK7). The STAT-signaling pathway is highly vulnerable to THZ1 even in PTCL cells that carry the activating STAT3 mutation Y640F. In mutant cells, CDK7 inhibition decreases STAT3 chromatin binding and expression of highly transcribed target genes like MYC, PIM1, MCL1, CD30, IL2RA, CDC25A and IL4R. In surviving cells, THZ1 dec...
  20. Immortalized colonic epithelial progenitor cells express stem cell markers and differentiate in vitro BioProject

    ID: PRJNA118233

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: quently immortalized with non-oncogenic proteins (cyclin dependent kinase 4 [CDK4] and the catalytic component of human telomerase [hTERT]), and maintained for well over a year in continuous cell culture. Immunofluorescence experiments reveal the immortalized populations of cells significantly express the progenitor epithelial cell marker mucin-1 and the colon epithelial specific marker A33. In addition, staining shows subsets of cells express chromogranin A, mucin-2, and dipeptyl peptidase 4, corresponding to neuroendocrine, mucus secreting, and absorptive colonic cell lineages, respectively. The cells also possess some mesenchymal features, including vimentin and α- smooth muscle actin expression when proliferating actively. Finally, i...

Displaying 20 of 27 results for "CDKL4"