CDKAL1 | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 8 of 8 results for "CDKAL1"
i
  1. Discovery of a Drug that Targets a Diabetes Gene identified by GWAS BioProject

    ID: PRJNA306865

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: WAS-identified candidate diabetes genes including CDKAL1, KCNQ1 and KCNJ11, and used directed differentiation to evaluate the function of derivative human beta-like cells. The mutations did not affect the generation of insulin+ cells, but impaired insulin secretion both in vitro and in vivo, coinciding with defective glucose homeostasis. CDKAL1-/- insulin+ cells also displayed hypersensitivity to lipotoxicity. A high-content c...
  2. Detailed analysis of 6p and 1q amplifications in urothelial carcinoma reveals SOX4 as an auxiliary target on 6p, and BCL9, CHDL1, MCL1, SETDB1, and HI... ArrayExpress

    ID: E-GEOD-40938

    Description: e E2F3. This gene is frequently co-amplified with CDKAL1 and SOX4 and there are reports on 6p22 amplifications that do not include the E2F3 locus. Previous array CGH analyses have indicated multiple possible target regions at 1q21-24. However, due to complex rearrangements it has been difficult to identify specific 1q21-24 target regions and target genes. Results: We show that the most commonly amplified ...

  3. CDKAL_XENTR UniProt:Swiss-Prot

    ID: Q6P4Y0

    Description: Threonylcarbamoyladenosine tRNA methylthiotransferase Helical MTTase N-terminal TRAM Iron-sulfur (4Fe-4S) Iron-sulfur (4Fe-4S) Iron-sulfur (4Fe-4S) Ir...

    gene.name: cdkal1
  4. CDKAL_XENLA UniProt:Swiss-Prot

    ID: Q6NS26

    Description: Threonylcarbamoyladenosine tRNA methylthiotransferase Helical MTTase N-terminal TRAM Iron-sulfur (4Fe-4S) Iron-sulfur (4Fe-4S) Iron-sulfur (4Fe-4S) Ir...

    gene.name: cdkal1
  5. Detailed analysis of 6p and 1q amplifications in urothelial carcinoma reveals SOX4 as an auxiliary target on 6p, and BCL9, CHDL1, MCL1, SETDB1, and HI... BioProject

    ID: PRJNA175405

    Keywords: Variation

    Access Type: download

    dataset.description: e E2F3. This gene is frequently co-amplified with CDKAL1 and SOX4 and there are reports on 6p22 amplifications that do not include the E2F3 locus. Previous array CGH analyses have indicated multiple possible target regions at 1q21-24. However, due to complex rearrangements it has been difficult to identify specific 1q21-24 target regions and target genes. Results: We show that the most commonly amplified g...
  6. Detailed analysis of 6p and 1q amplifications in urothelial carcinoma reveals SOX4 as an auxiliary target on 6p, and BCL9, CHDL1, MCL1, SETDB1, and HI... OmicsDI

    ID: E-GEOD-40938

    Date Released: 06-02-2014

    Description: e E2F3. This gene is frequently co-amplified with CDKAL1 and SOX4 and there are reports on 6p22 amplifications that do not include the E2F3 locus. Previous array CGH analyses have indicated multiple possible target regions at 1q21-24. However, due to complex rearrangements it has been difficult to identify specific 1q21-24 target regions and target genes. Results: We show that the most commonly amplified ...

  7. Prostate Cancer Genome-Wide Association Study for Uncommon Susceptibility Loci (PEGASUS) dbGaP

    ID: phs000882.v1.p1

    Description: (PKD1L3, rs12597458, P = 9.67 x 10-8) and 6p22.3 (CDKAL1, rs12198220, P = 2.13 x 10-7). In a combined case-only analysis of 12,518 prostate cancer cases, we identified two loci associated with Gleason score, a pathological measure of disease aggressiveness: rs35148638 at 5q14.3 (RASA1, P=6.49x10-9) and rs78943174 at 3q26.31 (NAALADL2, P=4.18x10-8). In a stratified case-control analysis, the SNP at 5q14.3 appears specific for aggressive prostate cancer (P=8.85x10-5) with no association for non-aggressive prostate cancer compared to controls (P=0.57). Only the cases and controls genotyped on the HumanOmni2.5 specifically for this study are included under this accession number. Controls (n=101) genotyped with the HumanOmni2.5 for another study are posted under a different accession number. Please note that the majority of prostate cancer cases and controls genotyped in CGEMS (and posted under a different accession number) are included in this study....

    Study Types: Case-Control

  8. Role of E2F3 expression in human bladder and prostate cancer cells BioProject

    ID: PRJNA97635

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ellular proliferation. In contrast, knockdown of CDKAL1/ FLJ20342, another proposed oncogene, from this amplicon had no effect. Expression cDNA microarray analysis on bladder cancer cells following E2F3 knockdown was then used to identify genes regulated by E2F3, leading to the identification of known E2F3 targets such as Cyclin A and CDC2 and novel targets including pituitary tumour transforming gene 1, Polo-like kinase 1 (PLK1) and Caveolin-2. For both bladder and prostate cancer, we have proposed that E2F3 protein overexpression may cooperate with removal of the E2F inhibitor retinoblastoma tumor suppressor protein (pRB) to drive cellular proliferation. In support of this model, we found that ectopi...

Displaying 8 of 8 results for "CDKAL1"