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Displaying 20 of 181 results for "CDK6"
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  1. Expression profile of BCR-ABL1-transformed, Cdk4 R24C, Cdk6 R31C cell lines OmicsDI

    ID: E-GEOD-59024

    Date Released: 11-08-2014

    Description: Cdk4 and Cdk6 are two related kinases that bind D-type cyclins and regulate cell cycle progression. Due to their relevance in cancer, Cdk4/6...

  2. CDK6 as key regulator of hematopoietic and leukemic stem cell activation. BioProject

    ID: PRJNA262936

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. C-JUN promotes BCR-ABL induced lymphoid leukemia by inhibiting methylation of the 5´ region of Cdk6 ArrayExpress

    ID: E-GEOD-27028

    Description: iated with the loss of cyclin dependent kinase 6 (CDK6) expression. In c-JunD/D cells CDK6 expression becomes down-regulated upon BCR-ABL induced transformation which correlates with CpG island methylation within the 5´ region of Cdk6. We verified the impact of Cdk6 deficiency by using Cdk6-/- mice that developed BCR-ABL induced B-lymphoid leukemia with significantly increased latency and an attenuated disease phenotype. In addition we show that re-expression of CDK6 in BCR-ABL transformed c-JunD/D cells reconstitutes proliferation and tumor formation in Nu/Nu mic...

  4. CDK6 as key regulator of hematopoietic and leukemic stem cell activation ArrayExpress

    ID: E-GEOD-62012

    Description: The cyclin-dependent kinases (CDK) CDK6 and CDK4 have redundant functions in regulating cell-cycle progression. We describe a novel role for CDK6 i...

  5. Expression profile of BCR-ABL1-transformed, Cdk4 R24C, Cdk6 R31C cell lines BioProject

    ID: PRJNA254153

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. CDK6 as key regulator of hematopoietic and leukemic stem cell activation. OmicsDI

    ID: E-GEOD-62012

    Date Released: 03-01-2015

    Description: The cyclin-dependent kinases (CDK) CDK6 and CDK4 have redundant functions in regulating cell-cycle progression. We describe a novel role for CDK6 i...

  7. C-JUN promotes BCR-ABL induced lymphoid leukemia by inhibiting methylation of the 5´ region of Cdk6 BioProject

    ID: PRJNA137685

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. P19INK4D/CDK6 COMPLEX PDB

    ID: PDB:1BLX

    Description: CYCLIN-DEPENDENT KINASE 6, P19INK4D

  9. Prolonged halting of gene expression in early G1 arrest by inhibition of CDK4/CDK6 reprograms myeloma cells for cytotoxic killing BioProject

    ID: PRJNA152133

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. CDK6 (monomeric) in complex with inhibitor PDB

    ID: PDB:4EZ5

    Description: Cyclin-dependent kinase 6 (E.C.2.7.11.22)

  11. STRUCTURE OF A P18(INK4C)-CDK6-K-CYCLIN TERNARY COMPLEX PDB

    ID: PDB:1G3N

    Description: CYCLIN-DEPENDENT KINASE 6 (E.C.2.7.1.37), CYCLIN-DEPENDENT KINASE 6 INHIBITOR, V-CYCLIN

  12. MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURES CDK6-P19INK4D INHIBITOR COMPLEX PDB

    ID: PDB:1BI8

    Description: CYCLIN-DEPENDENT KINASE 6, CYCLIN-DEPENDENT KINASE INHIBITOR

  13. CDK6 (monomeric) in complex with inhibitor PDB

    ID: PDB:3NUP

    Description: Cell division protein kinase 6 (E.C.2.7.11.22)

  14. CDK6 (monomeric) in complex with inhibitor PDB

    ID: PDB:3NUX

    Description: Cell division protein kinase 6 (E.C.2.7.11.22)

  15. C-JUN promotes BCR-ABL induced lymphoid leukemia by inhibiting methylation of the 5´ region of Cdk6 OmicsDI

    ID: E-GEOD-27028

    Date Released: 02-04-2011

    Description: iated with the loss of cyclin dependent kinase 6 (CDK6) expression. In c-JunD/D cells CDK6 expression becomes down-regulated upon BCR-ABL induced transformation which correlates with CpG island methylation within the 5´ region of Cdk6. We verified the impact of Cdk6 deficiency by using Cdk6-/- mice that developed BCR-ABL induced B-lymphoid leukemia with significantly increased latency and an attenuated disease phenotype. In addition we show that re-expression of CDK6 in BCR-ABL transformed c-JunD/D cells reconstitutes proliferation and tumor formation in Nu/Nu mic...

  16. Prolonged halting of gene expression in early G1 arrest by inhibition of CDK4/CDK6 reprograms myeloma cells for cytotoxic killing OmicsDI

    ID: E-GEOD-35728

    Date Released: 04-16-2012

    Description: By selective and reversible inhibition of CDK4/CDK6, we have developed a strategy to both inhibit proliferation and enhance cytotoxic killing of cancer cells. Induction of prolo...

  17. The X-ray co-crystal structure of human CDK6 and Abemaciclib. PDB

    ID: PDB:5L2S

    Description: Cyclin-dependent kinase 6 (E.C.2.7.11.22)

  18. The X-ray co-crystal structure of human CDK6 and Palbociclib. PDB

    ID: PDB:5L2I

    Description: Cyclin-dependent kinase 6 (E.C.2.7.11.22)

  19. Crystal structure of a complex of human CDK6 and a viral cyclin PDB

    ID: PDB:1JOW

    Description: CYCLIN HOMOLOG/CELL DIVISION PROTEIN KINASE 6 (E.C.2.7.1.-)

  20. FBX7_BOVIN UniProt:Swiss-Prot

    ID: Q2T9S7

    Description: raction with PINK1 Important for interaction with CDK6 Important for dimerization and interaction with PSMF1 Important for interaction with CDK6 RFDP motif Pro-rich...


Displaying 20 of 181 results for "CDK6"