CDK20 | bioCADDIE Data Discovery Index
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Displaying 20 of 105 results for "CDK20"
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  1. CDK20_MACMU UniProt:Swiss-Prot

    ID: Q5EDC3

    Description: Cyclin-dependent kinase 20 Protein kinase ATP Proton ac...

  2. CDK20_PONAB UniProt:Swiss-Prot

    ID: Q5R7I7

    Description: Cyclin-dependent kinase 20 Protein kinase ATP Proton ac...

  3. CDK20_RAT UniProt:Swiss-Prot

    ID: Q4KM34

    Description: Cyclin-dependent kinase 20 Protein kinase ATP Proton ac...

  4. CDK8/CYCC IN COMPLEX WITH COMPOUND 20 PDB

    ID: PDB:5HVY

    Description: Cyclin-dependent kinase 8 (E.C.2.7.11.22,2.7.11.23), Cyclin-C

  5. Clostridioides difficile P42 : Clostridioides difficile P42 Genome sequencing and assembly BioProject

    ID: PRJNA86015

    Keywords: Genome sequencing and assembly

    Access Type: download

  6. Fission yeast Cdk7 controls gene expression through both its CAK and CTD kinase activities BioProject

    ID: PRJNA137229

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. Cytoscan HD arrays data for Nodal marginal zone lymphoma (NMZL) BioProject

    ID: PRJNA281882

    Keywords: Variation

    Access Type: download

    dataset.description: , the cases investigated: i) lacked CD5, CD10 and cyclin D1 expression, 7q deletion, t(11;14), t(14;18), t(11;18) and t(1;14) translocations; and ii) recurrently harbored +3 (14%), +12 (14%) and preferential usage of the IGHV4-34 gene (17%). WES (HiSeq 2500, Illumina; mean coverage per sample: 38x-114x) and high resolution SNP array (Cytoscan HD, Affymetrix) of tumor/normal DNA pairs from 18 discovery NMZL identified 557 non-synonymous somatic mutations (average: 30.8/case) affecting 504 genes and 51 copy number abnormalities (CNA) (average: 3.2/case). To further characterize mutation recurrence, the 504 discovered genes were investigated in an independent validation panel of 17 NMZL by targeted sequencing of tumor/normal DNA pairs (MiSeq; target region: 1.6 Mb; mean coverage per sample: 171x-386x). The 17 validation NMZL w...
  8. P42-DEV368 NeuroMorpho.Org

    Type: image

    ID: 4137

  9. P42-DEV367 NeuroMorpho.Org

    Type: image

    ID: 4136

  10. P42-DEV369 NeuroMorpho.Org

    Type: image

    ID: 4138

  11. P42-DEV384 NeuroMorpho.Org

    Type: image

    ID: 4141

  12. SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR P16INK4A, 20 STRUCTURES PDB

    ID: PDB:1DC2

    Description: CYCLIN-DEPENDENT KINASE 4 INHIBITOR A (P16INK4A)

  13. P42-DEV375 NeuroMorpho.Org

    Type: image

    ID: 4140

  14. P42-DEV370 NeuroMorpho.Org

    Type: image

    ID: 4139

  15. P19-INK4D FROM MOUSE, NMR, 20 STRUCTURES PDB

    ID: PDB:1AP7

    Description: P19-INK4D

  16. Comparative genomic hybridization of frozen salivary or pulmonary adenoid cystic carcinoma samples and normal tissue to identify copy number alteratio... ArrayExpress

    ID: E-TABM-267

    Description: que alterations, there were gains harboring MDM2, cyclin D1, and KIT, as well as one loss involving the hsa-mir-124a-2 miRNA. Using immunohistochemistry, we found abnormal protein expression in the cases with gain of cyclin D1 or MDM2. In conclusion, the majority of previously reported chromosomal copy number alterations are found using array CGH in this small cohort. The suspicion that genes such as TP53, CDKN2A/CDKN2B, and VEGF might play a role in ACC, is strengthened by our results. CDK10 and LIMA1 emerge from our analysis as candidate cancer genes...

  17. A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferati... ArrayExpress

    ID: E-GEOD-54309

    Description: ion or prevent apoptosis. One of these, the lipid kinase phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP4K2A) regulates cellular levels of phosphatidylinositol-5-phosphate (PtsIns5P) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). We found PIP4K2A to be essential for the clonogenic and leukemia-initiating potential of human AML cells, and for the clonogenic potential of murine MLL-AF9 AML cells. Importantly, PIP4K2A is also required for the clonogenic potential of primary human AML c...

  18. Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts BioProject

    ID: PRJNA139487

    Keywords: Transcriptome or Gene expression

    Access Type: download

  19. Abrogation of stromal TGF-β signaling induces genetic alterations and SCC development in the neighboring epithelia ArrayExpress

    ID: E-GEOD-42773

    Description: Tgfbr2fspKO forestomach tissues. Genetic loss of cyclin-dependent kinase inhibitor, Cdkn2a/ p16Ink4A was found in laser captured epithelia of all three Tgfbr2fspKO forestomachs. Surprisingly, no genetic change was seen in the tumor associated stroma. Examination of human esophageal SCC showed a down-regulation of TGFβ receptor 2 (TβRII) in the stromal fibroblasts as well as increased inflammation and DNA damage. Published literature showed that loss of Cdkn2a/p16Ink4A tumor suppressor is the common event in human ESCCs. Our study suggests anti-inflammation may be a new therapeutic option in treating human SCCs with down-regulation of TβRII in the stroma. Laser capture microdissection of Tgfbr2flox/flox (n=3) and Tgfbr2fspKO (n=3) forestomach tissues was performed using an Arcturus XT (Life Technologies, CA, USA). Mouse background st...

  20. Expression data from chick embryos overexpressing NEUROG2 or NEUROG2AQ in the neural tube ArrayExpress

    ID: E-GEOD-37782

    Description: ve the cell cycle precedes the activation of this Cyclin-dependant Kinase Inhibitor. Moreover, NEUROG2 down-regulates only one of the D-type cyclins, cyclinD1, and maintaining cyclinD1 blocks the ability of the proneural to trigger cell cycle exit, without altering its capacity to trigger neuronal differentiation. The fact that NEUROG2 represses a subset but not all cell cycle regulators indicates that cell cycle exit is not an indirect consequence of neuronal differentiation but is precisely controlled by NEUROG2. Altogether our findings indicate that NEUROG2, by specifically repressing G1 and S cyclins, allows committed neuronal precursors to perform their last mitosis but blocks their re-entry in the cell cycle, thus favouring cell cycle exit. Stage HH10-11 embryos (11 to 15 somites) were electroporated with a control vector (pGIG-GFP), a NEUROG2-expressing vector (pCIGNEUROG2-GFP), or a NEUROG2AQ-expressing vector (pCIGNEUROG2AQ-GFP). For each biological replicate, neural tubes from 20 embryos were pooled for GFP+ cells collection. GFP+ ce...


Displaying 20 of 105 results for "CDK20"