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Displaying 20 of 87 results for "CD74"
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  1. CD74 role in transcription regulation [ChIP-seq] BioProject

    ID: PRJNA349181

    Keywords: Epigenomics

    Access Type: download

  2. CD74 role in transcription regulation [RNA-seq] BioProject

    ID: PRJNA349182

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. CD74 role in transcription regulation BioProject

    ID: PRJNA349179

    Access Type: download

  4. ed and treated with small interfering RNA against CD74 (siRNA CD74) or non-targeting siRNA (siRNA non-targeting)... OmicsDI

    ID: E-MTAB-3309

    Date Released: 02-11-2015

    Description: regnancy. This study aimed to analyze the role of CD74 in preeclampsia with a focus on its influence on communication between placental macrophages (Hofbauer cells) and trophoblasts. We have found CD74 to be highly dysregulated in preeclamptic placenta by real-time RT-PCR and Western blot methods. We identified Hofbauer cells to express the highest levels of CD74 ...

  5. CD74-NRG1 fusions in lung adenocarcinoma OmicsDI

    ID: EGAS00001000653

    Date Released:

    Description: We discovered a novel somatic gene fusion, CD74-NRG1, by transcriptome sequencing of 25 lung adenocarcinomas of never smokers. By screening 102 lung adenocarcinomas negative ...

  6. ed and treated with small interfering RNA against CD74 (siRNA CD74) or non-targeting siRNA (siRNA non-targeting)... ArrayExpress

    ID: E-MTAB-3309

    Description: regnancy. This study aimed to analyze the role of CD74 in preeclampsia with a focus on its influence on communication between placental macrophages (Hofbauer cells) and trophoblasts. We have found CD74 to be highly dysregulated in preeclamptic placenta by real-time RT-PCR and Western blot methods. We identified Hofbauer cells to express the highest levels of CD74 ...

  7. Comparisons between liver tissues and freshly isolated hepatocytes from IkkβF/F and IkkβDhep (Ikkβ-deleted) mice OmicsDI

    ID: E-GEOD-15476

    Date Released: 05-01-2014

    Description: CD74, a Type II membrane glycoprotein and MHC class II chaperone (Ii), is normally expressed by cells associated with the immune sy...

  8. Comparisons between liver tissues and freshly isolated hepatocytes from IkkβF/F and IkkβDhep (Ikkβ-deleted) mice ArrayExpress

    ID: E-GEOD-15476

    Description: CD74, a Type II membrane glycoprotein and MHC class II chaperone (Ii), is normally expressed by cells associated with the immune sy...

  9. Comparisons between liver tissues and freshly isolated hepatocytes from IkkβF/F and IkkβDhep (Ikkβ-deleted) mice BioProject

    ID: PRJNA115917

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: CD74, a Type II membrane glycoprotein and MHC class II chaperone (Ii), is normally expressed by cells associated with the immune sy...
  10. HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN PDB

    ID: PDB:1IIE

    Description: HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN

    gene.name: CD74 OR DHLAG
  11. HG2A_RAT UniProt:Swiss-Prot

    ID: P10247

    Description: H-2 class II histocompatibility antigen gamma chain Cytoplasmic Helical; Signal-anchor for type II membrane protein Extracellular Thyroglobulin type-1...

    gene.name: Cd74
  12. Quantitative Trait Locus and Brain Expression of HLA-DPA1 And Shared Immune Alterations in Psychiatric Disorders ArrayExpress

    ID: E-GEOD-78246

    Description: ial gene expression methods. A third MHC II mRNA, CD74, was studied outside of the MHC II locus, as it interacts within the same immune complex. HLA-DPA1 and CD74 were both reduced in hippocampus, amygdala, and dorsolateral prefrontal cortex regions in SZ and BD compared to controls by specific qPCR assay. We found several novel HLA-DPA1 mRNA variants spanning HLA-DPA1 exons 2-3-4 as suggested by an exon microarray study. The intronic rs9277341 SNP was a significant cis expression quantitative trait locus (eQTL) that was associated with the total expression of HLA-DPA1 in five brain regions. A biomarker study of MHC II mRNA...

  13. Cell Image Library Dataset CIL:33799 CIL

    ID: 33799

    Description: s been immunostained for the cell-surface antigen CD74. Nuclei are stained in blue. This image is part of a large collection of images generated from numerous specimens to characterize the distribution of CD74 in human prostate ...

    Data Types: image

  14. Cell Image Library Dataset CIL:33795 CIL

    ID: 33795

    Description: s been immunostained for the cell-surface antigen CD74. Nuclei are stained in blue. This image is part of a large collection of images generated from numerous specimens to characterize the distribution of CD74 in human prostate ...

    Data Types: image

  15. Cell Image Library Dataset CIL:33798 CIL

    ID: 33798

    Description: s been immunostained for the cell-surface antigen CD74. Nuclei are stained in blue. This image is part of a large collection of images generated from numerous specimens to characterize the distribution of CD74 in human prostate ...

    Data Types: image

  16. Gene regulation following MIF / IL-8 stimulation OmicsDI

    ID: E-GEOD-37430

    Date Released: 06-02-2014

    Description: gration inhibitory factor (MIF) and its receptor, CD74. Activation of cell surface CD84 initiates a signaling cascade that enhances CLL cell survival. Both immune-mediated neutralization or blockade of CD84 induce cell death in vitro and in vivo. In addition, analysis of samples derived from an on-going clinical trial, in which human subjects were treated with humanized anti-CD74 milatuzumab shows a decrease in CD84 mRNA levels milatuzumab-treated cells. This downregulation was correlated with reduction of Bcl-2 and Mcl-1 message. Thus, our data show that overexpression of CD84 in CLL is an important survival mechanism that appears to be an early event in the pathogen...

  17. Gene regulation following MIF stimulation. OmicsDI

    ID: E-GEOD-33352

    Date Released: 11-14-2011

    Description: for MK signaling in the previously described MIF/CD74 induced survival pathway. Stimulation of CD74 with MIF leads to c-Met activation, resulting in elevation of MK expression in both normal mouse splenic B and CLL cells. Our results indicate that MK and RPTPζ are important regulators of the B cell repertoire. These findings could pave the way towards understanding the mechanisms shaping B cell survival, and suggest novel therapeutic strategies based on the blockade of the midkine/RPTPζ-dependent survival pathway. 2 samples were incubated with or without MIF....

  18. Gene expression profiling of vasoregression in the retina ArrayExpress

    ID: E-GEOD-20967

    Description: re than twofold, the MHC class II invariant chain CD74 yielded the strongest upregulation, and was allocated to activated microglial cells close to the vessels undergoing vasoregression. Pathway clustering identified genes of the immune system, inflammatory signaling, and components of the complement cascade upregulated during vasoregression. Furthermore, macroglial cells were markedly activated. Together, our data suggest that glial cells involved in retinal immune response participate in the initiation of vasoregression in the retina. we used microarray techniques to define gene expression profiles related to vasoregression in a rat ciliopathy model. PKD-2-247 rats (TGR) and male Sprague-Dawley (SD) rats at 1 and 3 months of age were used for the analysis. ...

  19. Gene regulation following MIF stimulation ArrayExpress

    ID: E-GEOD-33352

    Description: for MK signaling in the previously described MIF/CD74 induced survival pathway. Stimulation of CD74 with MIF leads to c-Met activation, resulting in elevation of MK expression in both normal mouse splenic B and CLL cells. Our results indicate that MK and RPTPζ are important regulators of the B cell repertoire. These findings could pave the way towards understanding the mechanisms shaping B cell survival, and suggest novel therapeutic strategies based on the blockade of the midkine/RPTPζ-dependent survival pathway. 2 samples were incubated with or without MIF....

  20. Quantitative Trait Locus and Brain Expression of HLA-DPA1 And Shared Immune Alterations in Psychiatric Disorders OmicsDI

    ID: E-GEOD-78246

    Date Released: 02-26-2016

    Description: ial gene expression methods. A third MHC II mRNA, CD74, was studied outside of the MHC II locus, as it interacts within the same immune complex. HLA-DPA1 and CD74 were both reduced in hippocampus, amygdala, and dorsolateral prefrontal cortex regions in SZ and BD compared to controls by specific qPCR assay. We found several novel HLA-DPA1 mRNA variants spanning HLA-DPA1 exons 2-3-4 as suggested by an exon microarray study. The intronic rs9277341 SNP was a significant cis expression quantitative trait locus (eQTL) that was associated with the total expression of HLA-DPA1 in five brain regions. A biomarker study of MHC II mRNA...


Displaying 20 of 87 results for "CD74"