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Displaying 20 of 2,026 results for "CAP1"
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  1. Identification of the Candida albicans CAP1 regulon ArrayExpress

    ID: E-GEOD-14258

    Description: 1 genes involved in response to oxidative stress (CAP1, GLR1, TRX1, others), 13 genes involved in response to drug (PDR16, MDR1, FLU1, others) and 3 genes involved in regulation of nitrogen utilization (orf19.2693, orf19.3121 and GST3). Bioinformatic analyses suggested that Cap1p binds to the DNA motif 5'- MTKASTMA. Transcriptome analyses showed that increased expression of most of Cap1p targets accompanies Cap1p binding at these targets, indicating that Cap1p is a transcriptional activator. We conclude that, in addition to protecting the cell against oxidative stress, Cap1p appears to have other functions including drug resistance and the regulation of nitrogen utilization. The atypical binding pattern of Cap1p suggests that this transcription factor may associate with the transcriptional or the chromatin remodeling machinery to exert its activity. We performed three gene expression profile comparisons: (1) benomyl-induced gene expression in a strain containing wildtype CAP1 (CJD21/PMK-CAP1 +...

  2. Identification of the Candida albicans CAP1 regulon OmicsDI

    ID: E-GEOD-14258

    Date Released: 03-27-2012

    Description: 1 genes involved in response to oxidative stress (CAP1, GLR1, TRX1, others), 13 genes involved in response to drug (PDR16, MDR1, FLU1, others) and 3 genes involved in regulation of nitrogen utilization (orf19.2693, orf19.3121 and GST3). Bioinformatic analyses suggested that Cap1p binds to the DNA motif 5'- MTKASTMA. Transcriptome analyses showed that increased expression of most of Cap1p targets accompanies Cap1p binding at these targets, indicating that Cap1p is a transcriptional activator. We conclude that, in addition to protecting the cell against oxidative stress, Cap1p appears to have other functions including drug resistance and the regulation of nitrogen utilization. The atypical binding pattern of Cap1p suggests that this transcription factor may associate with the transcriptional or the chromatin remodeling machinery to exert its activity. We performed three gene expression profile comparisons: (1) benomyl-induced gene expression in a strain containing wildtype CAP1 (CJD21/PMK-CAP1 +...

  3. Identification of the Candida albicans CAP1 regulon BioProject

    ID: PRJNA111215

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans BioProject

    ID: PRJNA131763

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans ArrayExpress

    ID: E-GEOD-23532

    Description: tant mechanism of acquired drug resistance in the yeast Candida albicans. The zinc cluster transcription factor Mrr1 is a central regulator of MDR1 expression, but other transcription factors have also been implicated in MDR1 regulation. To bet...

  6. CRYSTAL STRUCTURE OF THE HUMAN C-TERMINAL CAP1-ADENYLYL CYCLASE ASSOCIATED PROTEIN PDB

    ID: PDB:1K8F

    Description: ADENYLYL CYCLASE-ASSOCIATED PROTEIN

  7. Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans OmicsDI

    ID: E-GEOD-23532

    Date Released: 07-12-2011

    Description: tant mechanism of acquired drug resistance in the yeast Candida albicans. The zinc cluster transcription factor Mrr1 is a central regulator of MDR1 expression, but other transcription factors have also been implicated in MDR1 regulation. To bet...

  8. YBP1_CANAL UniProt:Swiss-Prot

    ID: Q5AKU3

    Description: CAP1-binding-protein

  9. Identification of the Candida albicans Cap1p regulon (Cap1-CSE-HA and Cap1-HA complete datasets) BioProject

    ID: PRJNA114855

    Keywords: Epigenomics

    Access Type: download

  10. Identification of the Candida albicans Cap1p regulon (Cap1-CSE-HA and Cap1-HA complete datasets) ArrayExpress

    ID: E-GEOD-15104

    Description: s (P ≤ 0.02) included 11 genes involved in OSR (CAP1, GLR1, TRX1, SOD1, CAT1, others), 13 genes involved in response to drugs (PDR16, MDR1, FLU1, YCF1, FCR1, others), 4 genes involved in phospholipid transport (PDR16, GIT1, RTA2, orf19.932) and 3 genes involved in the regulation of nitrogen utilization (GST3, orf19.2693, orf19.3121), suggesting that Cap1p has other cellular functions in addition to OSR. Bioinformatic analyses of the bound sequences suggest that Cap1p recognizes the DNA motif 5'- MTKASTMA. Finally, transcriptome analyses showed that increased expression generally accompanies Cap1p binding at its targets, indicating that Cap1p functions as a transcriptional activator. Processing of raw data from 3 independent replicate samples for each Cap1 dataset was conducted using Tilescope (). Quantile normalization was applied to the data. The parameters used were as follows: window size of 400 bp, MaxGap of 60 bp and MinRun of 120 bp. The replicate data were combined and peak-finding (i.e. Cap1p-binding sites) was determined using the following criteria: pseudo-median signal threshold of ≥ 2-fold and p-value cut-off of ≤ 0.01....

  11. Identification of the Candida albicans Cap1p regulon (Cap1-CSE-HA and Cap1-HA complete datasets) OmicsDI

    ID: E-GEOD-15104

    Date Released: 05-04-2014

    Description: s (P ≤ 0.02) included 11 genes involved in OSR (CAP1, GLR1, TRX1, SOD1, CAT1, others), 13 genes involved in response to drugs (PDR16, MDR1, FLU1, YCF1, FCR1, others), 4 genes involved in phospholipid transport (PDR16, GIT1, RTA2, orf19.932) and 3 genes involved in the regulation of nitrogen utilization (GST3, orf19.2693, orf19.3121), suggesting that Cap1p has other cellular functions in addition to OSR. Bioinformatic analyses of the bound sequences suggest that Cap1p recognizes the DNA motif 5'- MTKASTMA. Finally, transcriptome analyses showed that increased expression generally accompanies Cap1p binding at its targets, indicating that Cap1p functions as a transcriptional activator. Processing of raw data from 3 independent replicate samples for each Cap1 dataset was conducted using Tilescope (http://tilescope.gersteinlab.org:8080/mosaic/pipeline.html). Quantile normalization was applied to the data. The parameters used were as follows: window size of 400 bp, MaxGap of 60 bp and MinRun of 120 bp. The replicate data were combined and peak-finding (i.e. Cap1p-binding sites) was determined using the following criteria: pseudo-median signal threshold of ≥ 2-fold and p-value cut-off of ≤ 0.01....

  12. CAP1_PONAB UniProt:Swiss-Prot

    ID: Q5R8B4

    Description: Removed Adenylyl cyclase-associated protein 1 C-CAP/cofactor C-like Ala/...

  13. CAP1_BOVIN UniProt:Swiss-Prot

    ID: Q3SYV4

    Description: Removed Adenylyl cyclase-associated protein 1 C-CAP/cofactor C-like Ala/...

  14. Transcription profling by array of Docetaxel resistant human prostate cancer cell lines established by exposure to different doses of Docetaxel ArrayExpress

    ID: E-MTAB-1221

    Description: atment. In this aim, we established resistant IGR-CaP1 prostate cancer cell lines to different doses of docetaxel (IGR-CaP1-R cell lines) and investigated gene expression profiles by microarray analyses. We generated a signature of 112 genes potentially implicated in docetaxel-resistance whose expression is highly modified (Fold change ≥ 5). Among these genes, significant modification of expression was observed among cell cycle components in the resistant cells. Hence, we focused on the role of the cell cycle regulator LZTS1 locat...

  15. Transcription profling by array of Docetaxel resistant human prostate cancer cell lines established by exposure to different doses of Docetaxel OmicsDI

    ID: E-MTAB-1221

    Date Released: 05-03-2014

    Description: atment. In this aim, we established resistant IGR-CaP1 prostate cancer cell lines to different doses of docetaxel (IGR-CaP1-R cell lines) and investigated gene expression profiles by microarray analyses. We generated a signature of 112 genes potentially implicated in docetaxel-resistance whose expression is highly modified (Fold change ≥ 5). Among these genes, significant modification of expression was observed among cell cycle components in the resistant cells. Hence, we focused on the role of the cell cycle regulator LZTS1 locat...

  16. Candida albicans response to spaceflight (NASA STS-115) ArrayExpress

    ID: E-GEOD-50881

    Description: ved. Interestingly, the transcriptional regulator Cap1 and over 30% of the Cap1 regulon was differentially expressed in spaceflight-cultured C. albicans. A potential role for Cap1 in the spaceflight response of C. albicans is suggested, as this regulator is involved in random budding, cell aggregation, actin cytoskeleton, and oxidative stress resistance; all related to observed spaceflight-associated changes of C. albicans. While culture of C. albicans in microgravity potentiates a global change in gene expression that could induce a virulence-related phenotype, no increased virulence in a murine intraperitoneal (i.p.) infection model was observed. This study represents an important basis for the assessment of the risk that commensal flora could play during spaceflight missions. Furthermore, since the low fluid-shear environment of microgravity is relevant to physical forces encountered by pathogens during the infection process, insights gained from this study could identify novel infectious disease mechanisms, with downstream benefits for the general public. Cells were grown for 24 hours on the space shuttle or as ground-based controls, preserved in RNALater, and stored at -80C. Four samples of each flight- and ground-based controls were harvested for m...

  17. Candida albicans response to spaceflight (NASA STS-115) OmicsDI

    ID: E-GEOD-50881

    Date Released: 06-03-2014

    Description: ved. Interestingly, the transcriptional regulator Cap1 and over 30% of the Cap1 regulon was differentially expressed in spaceflight-cultured C. albicans. A potential role for Cap1 in the spaceflight response of C. albicans is suggested, as this regulator is involved in random budding, cell aggregation, actin cytoskeleton, and oxidative stress resistance; all related to observed spaceflight-associated changes of C. albicans. While culture of C. albicans in microgravity potentiates a global change in gene expression that could induce a virulence-related phenotype, no increased virulence in a murine intraperitoneal (i.p.) infection model was observed. This study represents an important basis for the assessment of the risk that commensal flora could play during spaceflight missions. Furthermore, since the low fluid-shear environment of microgravity is relevant to physical forces encountered by pathogens during the infection process, insights gained from this study could identify novel infectious disease mechanisms, with downstream benefits for the general public. Cells were grown for 24 hours on the space shuttle or as ground-based controls, preserved in RNALater, and stored at -80C. Four samples of each flight- and ground-based controls were harvested for m...

  18. CaP-F363L-Kv3-3 NeuroMorpho.Org

    Type: image

    ID: 9366

    Activity: enhanced green fluorescent protein

  19. CaP-WT-Kv3-3 NeuroMorpho.Org

    Type: image

    ID: 9364

    Activity: enhanced green fluorescent protein

  20. CaP-R335H-Kv3-3 NeuroMorpho.Org

    Type: image

    ID: 9365

    Activity: enhanced green fluorescent protein


Displaying 20 of 2,026 results for "CAP1"