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Displaying 20 of 60 results for "CALR"
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  1. Comparison of expression profiles of Ba/F3 cells transduced with human CALR or human CALR + Type 1 mutation (hCALR-del52) by RNA-seq BioProject

    ID: PRJNA265360

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Physical interaction between mutant calreticulin and the thrombopoietin receptor is required for transformation of hematopoietic cells BioProject

    ID: PRJNA301731

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Somatic mutations in calreticulin (CALR) are present in approximately 40% of patients with myeloproliferative neoplasms (MPN). However, the mechanism by which mutant ...
  3. Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [MPN patients] ArrayExpress

    ID: E-GEOD-54644

    Description: K2 signature was present in patients with somatic CALR mutations. Conversely, we identified a gene expression signature of CALR mutations; this signature was significantly enriched in JAK2-mutant MPN patients consistent with a shared mechanism of transformation by JAK2 and CALR mutations. We also identified a transcriptional signature of TET2 mutations in MPN patent samples. Our data indicate that MPN patients, regardless of diagnosis or JAK mutational status are characterized by a distinct gene expression signature with upregulation of JAK-STAT target genes, demo...

  4. Aberrant Calreticulin expression in articular cartilage of Dio2 deficient mice BioProject

    ID: PRJNA315260

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ,5|) resulted in 1 probe located in Calreticulin (Calr) that was found significantly downregulated in Dio2-/- mice. The beneficial homeostatic state of articular cartilage in Dio2-/- mice is accompanied with significant lower expression of Calr. Functional analyses further showed that upregulation of Calr expression could act as an initiator of cartilage destruction. Overall design: To identify intrinsic differences in cartilage gene expression profiles between wild-type- and Dio2-/--mice, as a mechanis...
  5. Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [HEL cell lines] ArrayExpress

    ID: E-GEOD-54645

    Description: K2 signature was present in patients with somatic CALR mutations. Conversely, we identified a gene expression signature of CALR mutations; this signature was significantly enriched in JAK2-mutant MPN patients consistent with a shared mechanism of transformation by JAK2 and CALR mutations. We also identified a transcriptional signature of TET2 mutations in MPN patent samples. Our data indicate that MPN patients, regardless of diagnosis or JAK mutational status are characterized by a distinct gene expression signature with upregulation of JAK-STAT target genes, demo...

  6. Crystal structure of the globular domain of human calreticulin mutant D71K PDB

    ID: PDB:5LK5

    Description: Calreticulin,Calreticulin

    gene.name: CALR, CRTC
  7. Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [MPN patients] OmicsDI

    ID: E-GEOD-54644

    Date Released: 06-07-2014

    Description: K2 signature was present in patients with somatic CALR mutations. Conversely, we identified a gene expression signature of CALR mutations; this signature was significantly enriched in JAK2-mutant MPN patients consistent with a shared mechanism of transformation by JAK2 and CALR mutations. We also identified a transcriptional signature of TET2 mutations in MPN patent samples. Our data indicate that MPN patients, regardless of diagnosis or JAK mutational status are characterized by a distinct gene expression signature with upregulation of JAK-STAT target genes, demo...

  8. Crystal structure of the globular domain of human calreticulin PDB

    ID: PDB:3POS

    Description: Calreticulin

    gene.name: CALR, CRTC
  9. Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [MPN patients] BioProject

    ID: PRJNA237276

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: K2 signature was present in patients with somatic CALR mutations. Conversely, we identified a gene expression signature of CALR mutations; this signature was significantly enriched in JAK2-mutant MPN patients consistent with a shared mechanism of transformation by JAK2 and CALR mutations. We also identified a transcriptional signature of TET2 mutations in MPN patent samples. Our data indicate that MPN patients, regardless of diagnosis or JAK mutational status are characterized by a distinct gene expression signature with upregulation of JAK-STAT target genes, demo...
  10. Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [HEL cell lines] OmicsDI

    ID: E-GEOD-54645

    Date Released: 06-06-2014

    Description: K2 signature was present in patients with somatic CALR mutations. Conversely, we identified a gene expression signature of CALR mutations; this signature was significantly enriched in JAK2-mutant MPN patients consistent with a shared mechanism of transformation by JAK2 and CALR mutations. We also identified a transcriptional signature of TET2 mutations in MPN patent samples. Our data indicate that MPN patients, regardless of diagnosis or JAK mutational status are characterized by a distinct gene expression signature with upregulation of JAK-STAT target genes, demo...

  11. Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [HEL cell lines] BioProject

    ID: PRJNA237275

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: K2 signature was present in patients with somatic CALR mutations. Conversely, we identified a gene expression signature of CALR mutations; this signature was significantly enriched in JAK2-mutant MPN patients consistent with a shared mechanism of transformation by JAK2 and CALR mutations. We also identified a transcriptional signature of TET2 mutations in MPN patent samples. Our data indicate that MPN patients, regardless of diagnosis or JAK mutational status are characterized by a distinct gene expression signature with upregulation of JAK-STAT target genes, demo...
  12. Crystal structure of ERp29 D-domain in complex with the P-domain of calreticulin PDB

    ID: PDB:5V90

    Description: Endoplasmic reticulum resident protein 29, Calreticulin

    gene.name: CALR, CRTC
  13. RNA-seq/Transcriptome of Interphase and Mitotic Human Hepatoma Cell line. : We describe the expression of all genes in Human Hepatocellular cell line ... BioProject

    ID: PRJEB12539

    Keywords: Other

    Access Type: download

    dataset.description: R sheet (CLIM63) and housekeeping genes (CANX and CALR)....
  14. Crystal structure of the globular domain of human calreticulin PDB

    ID: PDB:3POW

    Description: calreticulin

    gene.name: CALR, CRTC
  15. Structural basis of carbohydrate recognition by calreticulin PDB

    ID: PDB:3O0X

    Description: Calreticulin

    gene.name: Calr
  16. Structural and functional relationships between the lectin and arm domains of calreticulin PDB

    ID: PDB:3RG0

    Description: Calreticulin

    gene.name: Calr
  17. Structural basis of carbohydrate recognition by calreticulin PDB

    ID: PDB:3O0W

    Description: Calreticulin

    gene.name: Calr
  18. Crystal structure of the calreticulin lectin domain PDB

    ID: PDB:3O0V

    Description: Calreticulin

    gene.name: Calr
  19. CALR_CANLF UniProt:Swiss-Prot

    ID: P28490

    Description: Calreticulin

    gene.name: CALR
  20. Germline duplication of ATG2B and GSKIP predisposes to familial essential thrombocythemia rapidly progressing to acute leukemia ArrayExpress

    ID: E-GEOD-67938

    Description: B and GSKIP cooperate with acquired JAK2, MPL and CALR mutations during MPN development. Thus, the germline duplication changes the fitness of cells harboring signaling mutations and increases the probability of disease development. 14 samples corresponding to iPSC and control cases (Cy5) where hybridized in dual color against commercial normal reference DNA (Cy3) of matched sex, except for samples with unknown gender for which male normal was used as reference....


Displaying 20 of 60 results for "CALR"