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Displaying 5 of 5 results for "C12orf65"
  1. Solution structure and siRNA-mediated knockdown analysis of the mitochondrial disease-related protein C12orf65 (ICT2) PDB

    ID: PDB:2RSM

    Description: Probable peptide chain release factor C12orf65 homolog, mitochondrial

  2. Homo sapiens : Identification of the causative gene for autosomal recessive spastic paraplegia with optic atrophy and neuropathy BioProject

    ID: PRJDB74

    Keywords: Exome

    Access Type: download

    dataset.description: mozygous nonsense mutation (c.394C>T, p.R132X) in Chromosome 12 open reading flame 65 (C12orf65) gene in two patients. C12orf65 gene mutation was not found in 74 Japanese AR-HSP patients without known HSP gene substitutions. Interpretation: The novel nonsense mutation in C12orf65 could be causative for AR-HSP with optic atrophy and neuropathy, resulting in a premature stop codon. Truncated C12orf65 protein would lead to the mitochondrial protein ...
  3. Eukaryotic Complete Release Factor family alignment (RF1, RF2, ICT1, C12orf65) Dryad

    DateIssued: 06-22-2012

    Description: Fasta multiple sequence alignment of all eukaryotic Release Factor proteins. Sequences were retrieved from GenBank nr database using PSI-BLAST. These ...

  4. Solution structure and siRNA-mediated knockdown analysis of the mitochondrial disease-related protein C12orf65 (ICT2) BMRB

    ID: 11491

    Creator: Enomoto, M. Tochio, N. Tomizawa, T. Koshiba, S. Guntert, P. Kigawa, T. Yokoyama, S. Nameki, N.

    Release Date: 2011-12-07Z

  5. Data from: Evolution and diversification of the organellar release factor family Dryad

    DateIssued: 02-12-2013

    Description: ors: mtRF1a, mtRF1, mtRF2a, mtRF2b, mtRF2c, ICT1, C12orf65, pRF1 and pRF2, and review published relevant experimental data. The canonical release factors (mtRF1a, mtRF2a, pRF1 and pRF2) and ICT1 are derived from bacterial ancestors, while the others have resulted from gene duplications of another release factor. These new RF family members have all lost one or more specific motifs relevant for bona fide release factor function but are mostly targeted to the same organelle as their ancestor. We also characterize the subset of canonical release factor proteins that bear non-classical PxT/SPF tripeptide motifs, and provide a molecular-model-based rationale for their retained ability to recognize stop codons. Finally we analyze the co-evolution of canonical RFs with the organellar genetic code. Although the RF presence in an organelle and its stop codon usage tend to co-evolve, we find three taxa that encode an RF2 without using UGA stop codons, and one reverse scenario, where mamiellales green algae use UGA stop codons in their mitochon...

Displaying 5 of 5 results for "C12orf65"