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Displaying 20 of 31 results for "BMP15"
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  1. BMP15_BOVIN UniProt:Swiss-Prot

    ID: Q6PX77

    Description: Bone morphogenetic protein 15 Pyrrolidone carboxylic acid N-linked (GlcNAc...

  2. Transcription profiling of mouse cumulus cells from Bmp15-/- and Bmp15-/-Gdf9+/--DM animals ArrayExpress

    ID: E-GEOD-7225

    Description: necessary for oocyte development. Oocyte-derived bone morphogenetic factor 15 (BMP15) and growth differentiation factor 9 (GDF9) appear to be key regulators of follicular development. The effect of these factors on cumulus cell function before th...

  3. Identification and characterization of the changed transcripts in cumulus cells of Bmp15-/- and Bmp15-/-Gdf9+/--DM mice. BioProject

    ID: PRJNA98279

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. Transcription profiling of mouse cumulus cells from Bmp15-/- and Bmp15-/-Gdf9+/--DM animals OmicsDI

    ID: E-GEOD-7225

    Date Released: 03-27-2012

    Description: necessary for oocyte development. Oocyte-derived bone morphogenetic factor 15 (BMP15) and growth differentiation factor 9 (GDF9) appear to be key regulators of follicular development. The effect of these factors on cumulus cell function before th...

  5. Transcription profiling by array of five isolated size matched populations of preantral follicles from normal human ovaries to evaluate the expression... ArrayExpress

    ID: E-MEXP-3783

    Description: , were isolated from ovarian tissue obtained from 15 women, aged 24–34 years. Isolated preantral follicles were grouped according to diameter in five size-matched populations spanning the primordial, primary and secondary stage follicles, and analyzed by whole-genome microarray analysis. Selected proteins/genes were analysed by immunocytochemistry and quantitative RT-PCR. TGF-beta superfamily genes with overall highest mRNA expressions levels included growth differentiation factors 9 (GDF9), bone morphogenic protein-15 (BMP15), BMP6, BMP-receptor-2 (BMPR2), anti-Müllerian hormone receptor 2 (AMHR2), TGFbetaR3, inhibin-alpha (INHA), and intracellular SMAD3 and SMAD4. Moreover, genes which were...

  6. BMP15_SHEEP UniProt:Swiss-Prot

    ID: Q9MZE2

    Description: Bone morphogenetic protein 15 Pyrrolidone carboxylic acid N-linked (GlcNAc...

  7. Cambridge sheep ovulation rate and infertility genes : Mapping a putative autosomal gene controlling ovulation rate and infertility in Cambridge sheep BioProject

    ID: PRJEB14098

    Keywords: Other

    Access Type: download

    dataset.description: ambridge breed and polymorphisms in both GDF9 and BMP15 have been shown to be associated with increased ovulation rate in heterozygous carriers and sterility in homozygous carriers in this breed. Recent data has provided evidence of a third major gene controlling ovulation rate in the Cambridge breed. The inheritance pattern suggests that this gene is autosomal and unlinked to GDF9 or BMP15. Mapping this gene was one of the goals of the EU-funded project 3SR, Sustainable Solutions for Small Ruminants. Sterile ewes with ovarian hypoplasia, where sterility cannot be explained by GDF9 or BMP15 polymorphisms, were identified along with their parents and 26 animals were genotyped using the Illumina ovine 50 Be...
  8. Estrus Synchronization and Ovarian Hyper Stimulation Treatments Have Negligible Effects on Cumulus Oocyte Complexes Gene Expression: Induction of Ovul... ArrayExpress

    ID: E-GEOD-41836

    Description: ental process and granulosa cell expansion (Gdf9, Bmp15, Amh, Amhr2, Bmpr1b, Tgfb2, Foxl2, Pde3a, Esr2, Fshr, Ybx2, Ccnd2, Ccnb1ip1, Zp3); maternal effect genes that are important for embryo development (Zar1, Npm2, Nlrp5, Dnmt1, H1foo, Zfp57); amino acid degradation and ketogenesis (Hmgcs2 , Cpt1b) were downregulated in G+E+Htrt. These results on rat model show that hormones used for estrus synchronization (Gtrt) and ovarian hyper stimulation (G+Etrt) had minimal effects on gene expression. However, induction of ovulation (G+E+Htrt) caused major changes in gene expression of rat COCs. This study provides comprehensive information about regulated genes during late follicle development and ovulation induction. Four experimental groups were used and there were 6 animals in each group. Total of 24 arrays were used. Only raw data used in publication....

  9. Transcription profiling by array of five isolated size matched populations of preantral follicles from normal human ovaries to evaluate the expression... OmicsDI

    ID: E-MEXP-3783

    Date Released: 05-08-2013

    Description: , were isolated from ovarian tissue obtained from 15 women, aged 24–34 years. Isolated preantral follicles were grouped according to diameter in five size-matched populations spanning the primordial, primary and secondary stage follicles, and analyzed by whole-genome microarray analysis. Selected proteins/genes were analysed by immunocytochemistry and quantitative RT-PCR. TGF-beta superfamily genes with overall highest mRNA expressions levels included growth differentiation factors 9 (GDF9), bone morphogenic protein-15 (BMP15), BMP6, BMP-receptor-2 (BMPR2), anti-Müllerian hormone receptor 2 (AMHR2), TGFbetaR3, inhibin-alpha (INHA), and intracellular SMAD3 and SMAD4. Moreover, genes which were ...

  10. Development of Laser Capture Microdissection to study the gene expression of the sheep early ovarian folliculogenesis ArrayExpress

    ID: E-GEOD-25652

    Description: -specific genes (SOHLH2, MAEL, MATER, VASA, GDF9, BMP15) and 3 granulosa cell-specific genes (KITLG, GATA4, AMH) confirmed the purity of the samples and documented their ovine expression profiles. Then, using bovine Affymetrix chip, we identified for the first time, a global gene expression for each follicular compartment during early developmental stages. Particularly the granulosa cell data set is quite unique. 1050 granulosa cell specific transcripts compared to oocyte and 759 oocyte specific transcripts were detected. The analysis of the expression of 2 genes (SIRT7, FST) confirmed this specificity of expression. Finally, the integration of the data stated the 3 main physiological events involved in early folliculogenesis and provided descriptive elements that confirmed the relevance and the potential of the LCM-derived RNAs. Conclusions This method should contribute through an additional genome wide expression profiling to give insights on molecular mechanisms involved in stage transitions and cell type interplays. The 2 ovine follicular compartments (i.e. granulosa cells (G) and oocytes (O) were captured using LCM technology for each early stage (primordial (Pd), primary (Pm), secondary (Sec) follicles. The RNA of each group was extracted using Picopure RNA Isolation kit (Arcturus) and subjected to 2 round T7 amplification (RiboAmp®HS PLUS kit, Arcturus). Ovine microarray experiments were performed using the Affymetrix Bovine Expression Array. First the quality of the cross-species hybridizations was checked by comparison of hybridization data of ovine fetal ovary RNA with bo...

  11. Estrus Synchronization and Ovarian Hyper Stimulation Treatments Have Negligible Effects on Cumulus Oocyte Complexes Gene Expression: Induction of Ovul... BioProject

    ID: PRJNA178294

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ental process and granulosa cell expansion (Gdf9, Bmp15, Amh, Amhr2, Bmpr1b, Tgfb2, Foxl2, Pde3a, Esr2, Fshr, Ybx2, Ccnd2, Ccnb1ip1, Zp3); maternal effect genes that are important for embryo development (Zar1, Npm2, Nlrp5, Dnmt1, H1foo, Zfp57); amino acid degradation and ketogenesis (Hmgcs2 , Cpt1b) were downregulated in G+E+Htrt. These results on rat model show that hormones used for estrus synchronization (Gtrt) and ovarian hyper stimulation (G+Etrt) had minimal effects on gene expression. However, induction of ovulation (G+E+Htrt) caused major changes in gene expression of rat COCs. This study provides comprehensive information about regulated genes during late follicle development and ovulation induction. Overall design: Four experimental groups were used and there were 6 animals in each group. Total of 24 arrays were used. Only raw data used in publication....
  12. Full genome time series analysis of the mulitple myeloma cell line IH-1 stimulated with BMP-4/IL6 or BMP-4/IL15 ArrayExpress

    ID: E-MTAB-619

    Description: line IH-1 was treated with BMP-4/IL-6 or BMP-4/IL-15 for 0, 0.5, 1, 2, 4 and 8 hrs (at 8 h also untreated cells)....

  13. Development of Laser Capture Microdissection to study the gene expression of the sheep early ovarian folliculogenesis BioProject

    ID: PRJNA133909

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: -specific genes (SOHLH2, MAEL, MATER, VASA, GDF9, BMP15) and 3 granulosa cell-specific genes (KITLG, GATA4, AMH) confirmed the purity of the samples and documented their ovine expression profiles. Then, using bovine Affymetrix chip, we identified for the first time, a global gene expression for each follicular compartment during early developmental stages. Particularly the granulosa cell data set is quite unique. 1050 granulosa cell specific transcripts compared to oocyte and 759 oocyte specific transcripts were detected. The analysis of the expression of 2 genes (SIRT7, FST) confirmed this specificity of expression. Finally, the integration of the data stated the 3 main physiological events involved in early folliculogenesis and provided descriptive elements that confirmed the relevance and the potential of the LCM-derived RNAs. Conclusions This method should contribute through an additional genome wide expression profiling to give insights on molecular mechanisms involved in stage transitions and cell type interplays. Overall design: The 2 ovine follicular compartments (i.e. granulosa cells (G) and oocytes (O) were captured using LCM technology for each early stage (primordial (Pd), primary (Pm), secondary (Sec) follicles. The RNA of each group was extracted using Picopure RNA Isolation kit (Arcturus) and subjected to 2 round T7 amplification (RiboAmp®HS PLUS kit, Arcturus). Ovine microarray experiments were performed using the Affymetrix Bovine Expression Array. First the quality of the cross-species hybridizations was checked by comparison of hybridization data of ovine fetal o...
  14. Data from: Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment Dryad

    DateIssued: 05-16-2017

    Description: Goats and sheep are versatile domesticates that have been integrated into diverse environments and production systems. Natural and artificial selectio...

    identifiers.ID: heredity-HDY-15-OR0040R
  15. Synergism between Activin A and BMP4 in directing the formation of definitive endoderm in human embryonic stem cells ArrayExpress

    ID: E-GEOD-30630

    Description: igand, BMP4, in combination with Activin A yields 15 to 20% more DE as compared to Activin A alone. The addition of recombinant BMP4 accelerates the downregulation of pluripotency factors, particularly SOX2, and results in upregulation of endogenous BMP2 and BMP4, which in turn leads to elevated levels of phospho-SMAD1/5/8 over the next three days of differentiation. Combined Activin A and BMP4 treatment also leads to an increase in the expression of DE genes CXCR4, SOX17 and FOXA2 when compared to Activin A addition alone. Comparative microarray studies between DE cells harvested on day 3 of diff...

  16. Estrus Synchronization and Ovarian Hyper Stimulation Treatments Have Negligible Effects on Cumulus Oocyte Complexes Gene Expression: Induction of Ovul... OmicsDI

    ID: E-GEOD-41836

    Date Released: 06-02-2014

    Description: ental process and granulosa cell expansion (Gdf9, Bmp15, Amh, Amhr2, Bmpr1b, Tgfb2, Foxl2, Pde3a, Esr2, Fshr, Ybx2, Ccnd2, Ccnb1ip1, Zp3); maternal effect genes that are important for embryo development (Zar1, Npm2, Nlrp5, Dnmt1, H1foo, Zfp57); amino acid degradation and ketogenesis (Hmgcs2 , Cpt1b) were downregulated in G+E+Htrt. These results on rat model show that hormones used for estrus synchronization (Gtrt) and ovarian hyper stimulation (G+Etrt) had minimal effects on gene expression. However, induction of ovulation (G+E+Htrt) caused major changes in gene expression of rat COCs. This study provides comprehensive information about regulated genes during late follicle development and ovulation induction. Four experimental groups were used and there were 6 animals in each group. Total of 24 arrays were used. Only raw data used in publication....

  17. Synergism between Activin A and BMP4 in directing the formation of definitive endoderm in human embryonic stem cells BioProject

    ID: PRJNA144583

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: igand, BMP4, in combination with Activin A yields 15 to 20% more DE as compared to Activin A alone. The addition of recombinant BMP4 accelerates the downregulation of pluripotency factors, particularly SOX2, and results in upregulation of endogenous BMP2 and BMP4, which in turn leads to elevated levels of phospho-SMAD1/5/8 over the next three days of differentiation. Combined Activin A and BMP4 treatment also leads to an increase in the expression of DE genes CXCR4, SOX17 and FOXA2 when compared to Activin A addition alone. Comparative microarray studies between DE cells harvested on day 3 of diff...
  18. Gene expression analysis of granulosa cells from Fzd1 WT and KO mice OmicsDI

    ID: E-GEOD-38315

    Date Released: 09-26-2012

    Description: unted response of both oocyte (Zp3, Dppa3, Nlrp5, Bmp15) and cumulus (Btc, Ptgs2, Sema3a, Ptx3, Il6, Nts, Alcam, Cspg2) genes to the ovulatory signal, whereas the expression of these genes was not altered in WNT4-deficient COCs from Wnt4tm1.1Boer/tm1.1Boer;Tg(CYP19A1-cre)1Jri mice. Despite altered gene expression, cumulus expansion appeared normal in Fzd1-/- COCs both in vitro and in vivo. Together, these results indicate that Fzd1 is required for normal female fertility and may act in part to regulate oocyte maturation and cumulus cell function, but is unlikely to function as the sole ovarian WNT4 receptor. Triplicate RNA samples from granulosa cells of Fzd1 KO mice are compared to triplicate RNA samples from granulosa cells of control Fzd1 WT mice...

  19. Identification of candidate predisposing copy number variants in familial and early-onset colorectal cancer patients ArrayExpress

    ID: E-GEOD-13429

    Description: novel copy number variants (CNVs) in 6 patients (15%) encompassing, among others, the cadherin gene CDH18, the bone morphogenetic protein antagonist family gene GREM1, and the breakpoint cluster region gene BCR. In addition, two genomic deletions were encountered encompassing two microRNA genes, hsa-mir-491/KIAA1797 and hsa-mir-646/AK309218. None of these CNVs has previously been reported in relation to CRC predisposition in humans, nor were they encountered in large control cohorts (>1,600 unaffected individuals). Since several of these newly identified candidate genes may be functionally linked to CRC development, our results illustrate the potential of ...

  20. Gene expression analysis of granulosa cells from Fzd1 WT and KO mice ArrayExpress

    ID: E-GEOD-38315

    Description: unted response of both oocyte (Zp3, Dppa3, Nlrp5, Bmp15) and cumulus (Btc, Ptgs2, Sema3a, Ptx3, Il6, Nts, Alcam, Cspg2) genes to the ovulatory signal, whereas the expression of these genes was not altered in WNT4-deficient COCs from Wnt4tm1.1Boer/tm1.1Boer;Tg(CYP19A1-cre)1Jri mice. Despite altered gene expression, cumulus expansion appeared normal in Fzd1-/- COCs both in vitro and in vivo. Together, these results indicate that Fzd1 is required for normal female fertility and may act in part to regulate oocyte maturation and cumulus cell function, but is unlikely to function as the sole ovarian WNT4 receptor. Triplicate RNA samples from granulosa cells of Fzd1 KO mice are compared to triplicate RNA samples from granulosa cells of control Fzd1 WT mice...


Displaying 20 of 31 results for "BMP15"