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Displaying 13 of 13 results for "BHLHE41"
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  1. Essential role of the transcription factor Bhlhe41 in regulating the self-renewal and BCR repertoire of B-1a cells BioProject

    ID: PRJNA362312

    Keywords: Other

    Access Type: download

  2. Homo sapiens strain:ACHN : Functional characterization of the 12p12.1 renal cancer susceptibility locus implicates BHLHE41 BioProject

    ID: PRJNA309249

    Keywords: raw sequence reads

    Access Type: download

  3. Expression data from adult mouse cortex harvested at two different zeitgeber (ZT) timepoints of the 24h cycle ArrayExpress

    ID: E-GEOD-59941

    Description: of loss of SHARP1 (DEC2/BHLHE40) and SHARP2 (DEC1/BHLHE41) on cortical gene expression at rest (ZT4) and activity (ZT16) phases. We harvested cortex tissue from individual mice from WT and SHARP1/2 double null mutant mice at ZT4 and ZT16, prepared total RNA and subjected the corresponding samples (n=2 biological replicates per timepoint and genotype) to Affymetrix genechip analysis to assay the changes of gene expression....

  4. Expression data from adult mouse cortex harvested at two different zeitgeber (ZT) timepoints of the 24h cycle BioProject

    ID: PRJNA257098

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: of loss of SHARP1 (DEC2/BHLHE40) and SHARP2 (DEC1/BHLHE41) on cortical gene expression at rest (ZT4) and activity (ZT16) phases. Overall design: We harvested cortex tissue from individual mice from WT and SHARP1/2 double null mutant mice at ZT4 and ZT16, prepared total RNA and subjected the corresponding samples (n=2 biological replicates per timepoint and genotype) to Affymetrix genechip analysis to assay the changes of gene expression....
  5. Identification of immediate early genes that are involved in G0-G1 transition of hepatocytes after injury by use of an ex vivo liver slice system ArrayExpress

    ID: E-GEOD-65995

    Description: of the basic helix-loop-helix family, Bhlhe40 and Bhlhe41, were highly upregulated for 4 h after injury. Although upon injury Jun or Egr1 were induced in liver slices from proliferation-defective liver, no circadian clock regulator genes were upregulated. Moreover, using an in vitro cell culture system we show that Bhlhe40 is required for the G0-G1 transition. Conclusion: Our data suggest that the circadian clock regulator, Bhlhe40, is involved in the G0-G1 transition. An ex vivo system using normal and proliferation defective KO liver is a useful tool for identification of genes that trigger cell proliferation shortly after liver injury. This method may also be applied for measurement of the liver regeneration potential of individual livers at the priming phase. In one dual-color microarray hybridization, mRNA expression changes after 2h ex vivo incubation of liver slices were examined....

  6. Expression data from adult mouse cortex harvested at two different zeitgeber (ZT) timepoints of the 24h cycle OmicsDI

    ID: E-GEOD-59941

    Date Released: 11-30-2014

    Description: of loss of SHARP1 (DEC2/BHLHE40) and SHARP2 (DEC1/BHLHE41) on cortical gene expression at rest (ZT4) and activity (ZT16) phases. We harvested cortex tissue from individual mice from WT and SHARP1/2 double null mutant mice at ZT4 and ZT16, prepared total RNA and subjected the corresponding samples (n=2 biological replicates per timepoint and genotype) to Affymetrix genechip analysis to assay the changes of gene expression....

  7. Circadian patterns of gene expression in the human brain and disruption in major depressive disorder ArrayExpress

    ID: E-GEOD-45642

    Description: PER1-2-3, NR1D1(REV-ERB), DBP, BHLHE40(DEC1), and BHLHE41(DEC2). The phasing of known circadian genes was consistent with data derived from other diurnal mammals. Cyclic patterns were much weaker in MDD brains, due to shifted peak timing and potentially disrupted phase relationships between individual circadian genes. This is the first transcriptome-wide analysis of cyclic patterns in the human brain and demonstrates a rhythmic rise and fall of gene expression in regions outside of the suprachiasmatic nucleus in control subjects. The description of its breakdown in MDD suggest novel molecular targets for treatment of mood disorders. Sample collection, including human subject recruitment and characterization, tissue dissection, and RNA extraction, was described previously (see Evans 2003 Neurobiol Dis 14:240-250, Li 2004 Biol Psychiatry 55:346-352). RNA samples for different regions came from the same set of brains from 86 control subjects. Sample size varied by region: AnCg (n=70 controls), DLPFC (n=83), CB (n=51), AMY (n=32), HC (n=63) and NAcc (n=66). Many of the samples were run on two or more chips, resulting in the following chip counts for each region: AnCg = 124, DLPFC = 161, CB = 79, AMY = 62, HC = 108 and NaCC = 136. We ran each sample on at least two microarrays using ...

  8. SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors ArrayExpress

    ID: E-GEOD-33950

    Description: Triple Negative Breast cancer accounts for some of the most aggressive types of breast cancer. By interrogating clinical datasets, we found that the a...

  9. Identification of immediate early genes that are involved in G0-G1 transition of hepatocytes after injury by use of an ex vivo liver slice system. OmicsDI

    ID: E-GEOD-65995

    Date Released: 01-01-2016

    Description: of the basic helix-loop-helix family, Bhlhe40 and Bhlhe41, were highly upregulated for 4 h after injury. Although upon injury Jun or Egr1 were induced in liver slices from proliferation-defective liver, no circadian clock regulator genes were upregulated. Moreover, using an in vitro cell culture system we show that Bhlhe40 is required for the G0-G1 transition. Conclusion: Our data suggest that the circadian clock regulator, Bhlhe40, is involved in the G0-G1 transition. An ex vivo system using normal and proliferation defective KO liver is a useful tool for identification of genes that trigger cell proliferation shortly after liver injury. This method may also be applied for measurement of the liver regeneration potential of individual livers at the priming phase. In one dual-color microarray hybridization, mRNA expression changes after 2h ex vivo incubation of liver slices were examined....

  10. Circadian patterns of gene expression in the human brain and disruption in major depressive disorder BioProject

    ID: PRJNA198068

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: PER1-2-3, NR1D1(REV-ERB), DBP, BHLHE40(DEC1), and BHLHE41(DEC2). The phasing of known circadian genes was consistent with data derived from other diurnal mammals. Cyclic patterns were much weaker in MDD brains, due to shifted peak timing and potentially disrupted phase relationships between individual circadian genes. This is the first transcriptome-wide analysis of cyclic patterns in the human brain and demonstrates a rhythmic rise and fall of gene expression in regions outside of the suprachiasmatic nucleus in control subjects. The description of its breakdown in MDD suggest novel molecular targets for treatment of mood disorders. Overall design: Sample collection, including human subject recruitment and characterization, tissue dissection, and RNA extraction, was described previously (see Evans 2003 Neurobiol Dis 14:240-250, Li 2004 Biol Psychiatry 55:346-352). RNA samples for different regions came from the same set of brains from 86 control subjects. Sample size varied by region: AnCg (n=70 controls), DLPFC (n=83), CB (n=51), AMY (n=32), HC (n=63) and NAcc (n=66). Many of the samples were run on two or more chips, resulting in the following chip counts for each region: AnCg = 124, DLPFC = 161, CB = 79, AMY = 62, HC = 108 and NaCC = 136. We ran each sample on at least two mi...
  11. SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors BioProject

    ID: PRJNA150029

    Keywords: Transcriptome or Gene expression

    Access Type: download

  12. Circadian patterns of gene expression in the human brain and disruption in major depressive disorder OmicsDI

    ID: E-GEOD-45642

    Date Released: 04-29-2013

    Description: PER1-2-3, NR1D1(REV-ERB), DBP, BHLHE40(DEC1), and BHLHE41(DEC2). The phasing of known circadian genes was consistent with data derived from other diurnal mammals. Cyclic patterns were much weaker in MDD brains, due to shifted peak timing and potentially disrupted phase relationships between individual circadian genes. This is the first transcriptome-wide analysis of cyclic patterns in the human brain and demonstrates a rhythmic rise and fall of gene expression in regions outside of the suprachiasmatic nucleus in control subjects. The description of its breakdown in MDD suggest novel molecular targets for treatment of mood disorders. Sample collection, including human subject recruitment and characterization, tissue dissection, and RNA extraction, was described previously (see Evans 2003 Neurobiol Dis 14:240-250, Li 2004 Biol Psychiatry 55:346-352). RNA samples for different regions came from the same set of brains from 86 control subjects. Sample size varied by region: AnCg (n=70 controls), DLPFC (n=83), CB (n=51), AMY (n=32), HC (n=63) and NAcc (n=66). Many of the samples were run on two or more chips, resulting in the following chip counts for each region: AnCg = 124, DLPFC = 161, CB = 79, AMY = 62, HC = 108 and NaCC = 136. We ran each sample on at least two microarrays using ...

  13. Circadian modulators SHARP1/SHARP2 deficiency effect on cortex: time course GEO

    ID: geo.datasets:GDS5423

    Description: phase). bHLH transcription factors SHARP1 (DEC2, BHLHE41) and SHARP2 (DEC1, BHLHE40) are circadian modulators. Results provide insight into the molecular contributions of SHARP1/SHARP2 to the sleep-wake cycle....

    Types: Expression profiling by array

    Instrument: GPL81


Displaying 13 of 13 results for "BHLHE41"