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Displaying 20 of 26 results for "BARD1"
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  1. Solution structure of the BRCA1/BARD1 RING-domain heterodimer PDB

    ID: PDB:1JM7

    Description: BRCA1, BARD1

  2. Crystal Structure of the BARD1 Ankyrin Repeat Domain and Its Functional Consequences PDB

    ID: PDB:3C5R

    Description: BRCA1-associated RING domain protein 1

  3. Crystal Structure of the BRCA1 Associated Ring Domain (BARD1) Tandem BRCT Domains PDB

    ID: PDB:3FA2

    Description: BRCA1-associated RING domain protein 1

  4. Crystal Structure of the BARD1 BRCT Domains PDB

    ID: PDB:2NTE

    Description: BRCA1-associated RING domain protein 1

  5. Crystal Structure of the BARD1 BRCT Repeat PDB

    ID: PDB:2R1Z

    Description: BRCA1-associated RING domain protein 1

  6. miRNA expression profiling of NB4 control cells versus NB4 cells treated with SAHA (Vorinostat) OmicsDI

    ID: E-GEOD-37374

    Date Released: 01-02-2015

    Description: For a long time, the BARD1 (BRCA1-associated RING domain 1) protein has been considered as a BRCA1 (BReast Cancer susceptibility gene 1, early onset) in...

  7. miRNA expression profiling of NB4 control cells versus NB4 cells treated with SAHA (Vorinostat) ArrayExpress

    ID: E-GEOD-37374

    Description: For a long time, the BARD1 (BRCA1-associated RING domain 1) protein has been considered as a BRCA1 (BReast Cancer susceptibility gene 1, early onset) in...

  8. miRNA expression profiling of NB4 control cells versus NB4 cells treated with SAHA (Vorinostat) BioProject

    ID: PRJNA159569

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: For a long time, the BARD1 (BRCA1-associated RING domain 1) protein has been considered as a BRCA1 (BReast Cancer susceptibility gene 1, early onset) in...
  9. BRCT phosphoprotein recognition, but not E3 ligase activity, is essential for BRCA1 tumor suppression ArrayExpress

    ID: E-GEOD-31673

    Description: n recognized that BRCA1, in the form of the BRCA1/BARD1 heterodimer, acting as an ubiquitin E3 ligase offered a possible mechanism to explain its pleiotrophic nature of BRCA1 activity. Our o...

  10. BARD1_RAT UniProt:Swiss-Prot

    ID: Q9QZH2

    Description: BRCA1-associated RING domain protein 1 ANK 1 ANK 2 ANK 3 ANK 4; degenerate BRCT 1 BRCT 2 RING-type Required for BRCA1 binding Flexible linker Poly-Leu...

    gene.name: Bard1
  11. BRCT phosphoprotein recognition, but not E3 ligase activity, is essential for BRCA1 tumor suppression BioProject

    ID: PRJNA145367

    Keywords: Variation

    Access Type: download

    dataset.description: n recognized that BRCA1, in the form of the BRCA1/BARD1 heterodimer, acting as an ubiquitin E3 ligase offered a possible mechanism to explain its pleiotrophic nature of BRCA1 activity. Our o...
  12. Dynamic interplay between locus-specific DNA methylation and hydroxymethylation regulates distinct biological pathways in prostate carcinogenesis ArrayExpress

    ID: E-GEOD-74464

    Description: pression in critical functional pathways, such as BARD1 signaling and steroid hormone receptor signaling in cancer. We confirm a modest correlation of hydroxymethylation with expression in intragenic regions in prostate cancer, while identifying an original role for intergenic hydroxymethylation in differentially expressed regulatory pathways in cancer. We also demonstrate a successful strategy for the identification and validation of key candidate genes from differentially regulated biological pathways in prostate cancer. Conclusion: Our results indicate a distinct function for aberrant hydroxymethylation within each genomic feature in cancer, suggesting a specific and complex role for the deregulation of hydroxymethylation in tumorigenesis, similar to methylation. Subsequently, our characterization of key cellular pathways exhibiting dynamic enrichment patterns for methylation and hydroxymethylation marks may allow us to identify differentially epigenetically modified target genes implicated i...

  13. Bisphenol A Induced the Expression of DNA Repair Genes in Human Breast Epithelial Cells (methylation data) ArrayExpress

    ID: E-GEOD-27865

    Description: se cells showed an increased expression of BRCA1, BARD1, CtIP, RAD51 and BRCC3, all genes involved in DNA repair, and downregulation of PDCD5 and BCL2L11 (also known as BIM), both involved in apoptosis. The upregulation of CtIP was related to hypomethylation of the promoter/exon1 of this gene. Furthermore, BPA induced silencing of BCL2L11 by hypermethylation. This is the first demonstration that BPA induces neoplastic transformation of breast epithelial cells and that aberrant DNA methylation of genes involved in DNA repair and apoptosis could be involved in the initiation of the neoplastic process. MCF-10F, a normal-like Homo sapiens breast epithelial cell (HBEC) line that is ERa-negative PR-negative, was maintained in high calcium medium at 37°C and 5% CO2 until confluent. These cells were treated with different concentrations of BPA continuously for two weeks, adding fresh media every day. As controls, MCF-10F cells were not treated and maintained in the regular media or treated with 0.284% DMSO (vehicle). The cells treated with 10-5M or 10-6M BPA after the invasion assay were collected and expanded during 6 passages. DNA was isolated from the cells using a DNA extraction kit (Qiagen)....

  14. Bisphenol A Induced the Expression of DNA Repair Genes in Human Breast Epithelial Cells ArrayExpress

    ID: E-GEOD-26884

    Description: se cells showed an increased expression of BRCA1, BARD1, CtIP, RAD51 and BRCC3, all genes involved in DNA repair, and downregulation of PDCD5 and BCL2L11 (also known as BIM), both involved in apoptosis. The upregulation of CtIP was related to hypomethylation of the promoter/exon1 of this gene. Furthermore, BPA induced silencing of BCL2L11 by hypermethylation. This is the first demonstration that BPA induces neoplastic transformation of breast epithelial cells and that aberrant DNA methylation of genes involved in DNA repair and apoptosis could be involved in the initiation of the neoplastic process. MCF-10F, a normal-like Homo sapiens breast epithelial cell (HBEC) line that is ERa-negative PR-negative was maintained in high calcium medium at 37°C and 5% CO2 until confluent. These cells were treated with different concentrations of BPA continuously for two weeks, adding fresh media every day. As controls, MCF-10F cells were not treated and maintained in the regular media or treated with 0.284% DMSO (vehicle). The cells treated with 10-5M or 10-6M BPA after the invasion assay were collected and expanded during 6 passages. RNA was isolated from the cells using RNA extraction kit (Quiagen)....

  15. Bisphenol A Regulates the Expression of DNA Repair Genes in Human Breast Epithelial Cells (expression data) ArrayExpress

    ID: E-GEOD-32158

    Description: se cells showed an increased expression of BRCA1, BARD1, CtIP, RAD51 and BRCC3, all genes involved in DNA repair, and downregulation of PDCD5 and BCL2L11 (also known as BIM), both involved in apoptosis. The upregulation of CtIP was related to hypomethylation of the promoter/exon1 of this gene. Furthermore, BPA induced silencing of BCL2L11 by hypermethylation. This is the first demonstration that BPA induces neoplastic transformation of breast epithelial cells and that aberrant DNA methylation of genes involved in DNA repair and apoptosis could be involved in the initiation of the neoplastic process. MCF-10F, a normal-like human breast epithelial cell (HBEC) line that is ERalpha-negative PR-negative, was maintained in high-calcium medium at 37°C and 5% CO2 until confluent. These cells were treated with different concentrations of BPA continuously for two weeks, adding fresh media every day. As controls, MCF-10F cells were not treated and maintained in the regular media or treated with 0.284% DMSO (vehicle). The cells treated with 10-5M or 10-6M BPA after the invasion assay were collected and expanded during 6 passages. RNA was isolated from the cells using an RNA extraction kit (Qiagen)....

  16. A 13-gene signature predicting rapid development of brain metastases in breast cancer BioProject

    ID: PRJNA167135

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ngly, three of the genes in the signature (RAD51, BARD1, FANCG) function in DNA double strand break repair. Overexpression of RAD51 in immortal MCF-10A breast epithelial cells altered their three-dimensional acinar morphology to increase the percentage of invasive structures by 6.5 fold, in the presence or absence of HER2 overexpression. In summary, ER negativity and a novel 13-gene signature may have the potential to identify subpopulations at highest immediate risk for the development of brain metastases in HER2-positive advanced breast cancer. Our results also suggest that RAD51, found in the 13-gene signature, may promote aggressiveness in breast epithelial cells. These data may be useful in the design of brain metastasis preventive trials and may prompt new treatment strategies Median normalized data provided Overall design: Using Illumina DASL Cancer gene panel we analyzed gene expression of 502 oncogenes in 87 breast cancer patients. The data was divided into a training (n=62) and an internal vali...
  17. BRCT phosphoprotein recognition, but not E3 ligase activity, is essential for BRCA1 tumor suppression OmicsDI

    ID: E-GEOD-31673

    Date Released: 06-02-2014

    Description: n recognized that BRCA1, in the form of the BRCA1/BARD1 heterodimer, acting as an ubiquitin E3 ligase offered a possible mechanism to explain its pleiotrophic nature of BRCA1 activity. Our o...

  18. Bisphenol A Induced the Expression of DNA Repair Genes in Human Breast Epithelial Cells BioProject

    ID: PRJNA136123

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: se cells showed an increased expression of BRCA1, BARD1, CtIP, RAD51 and BRCC3, all genes involved in DNA repair, and downregulation of PDCD5 and BCL2L11 (also known as BIM), both involved in apoptosis. The upregulation of CtIP was related to hypomethylation of the promoter/exon1 of this gene. Furthermore, BPA induced silencing of BCL2L11 by hypermethylation. This is the first demonstration that BPA induces neoplastic transformation of breast epithelial cells and that aberrant DNA methylation of genes involved in DNA repair and apoptosis could be involved in the initiation of the neoplastic process. Overall design: MCF-10F, a normal-like Homo sapiens breast epithelial cell (HBEC) line that is ERa-negative PR-negative, was maintained in high calcium medium at 37°C and 5% CO2 until confluent. These cells were treated with different concentrations of BPA continuously for two weeks, adding fresh media every day. As controls, MCF-10F cells were not treated and maintained in the regular media or treated with 0.284% DMSO (vehicle). The cells treated with 10-5M or 10-6M BPA after the invasion assay were collected and expanded during 6 passages. RNA was isolated from the cells using an RNA extraction kit (Qiagen)....
  19. Dynamic interplay between locus-specific DNA methylation and hydroxymethylation regulates distinct biological pathways in prostate carcinogenesis BioProject

    ID: PRJNA300503

    Keywords: Epigenomics

    Access Type: download

    dataset.description: pression in critical functional pathways, such as BARD1 signaling and steroid hormone receptor signaling in cancer. We confirm a modest correlation of hydroxymethylation with expression in intragenic regions in prostate cancer, while identifying an original role for intergenic hydroxymethylation in differentially expressed regulatory pathways in cancer. We also demonstrate a successful strategy for the identification and validation of key candidate genes from differentially regulated biological pathways in prostate cancer. Conclusion: Our results indicate a distinct function for aberrant hydroxymethylation within each genomic feature in cancer, suggesting a specific and complex role for the deregulation of hydroxymethylation in tumorigenesis, similar to methylation. Subsequently, our characterization of key cellular pathways exhibiting dynamic enrichment patterns for methylation and hydroxymethylation marks may allow us to identify differentially epigenetically modified target genes implicated i...
  20. Bisphenol A Induced the Expression of DNA Repair Genes in Human Breast Epithelial Cells (methylation data) BioProject

    ID: PRJNA153921

    Keywords: Epigenomics

    Access Type: download

    dataset.description: se cells showed an increased expression of BRCA1, BARD1, CtIP, RAD51 and BRCC3, all genes involved in DNA repair, and downregulation of PDCD5 and BCL2L11 (also known as BIM), both involved in apoptosis. The upregulation of CtIP was related to hypomethylation of the promoter/exon1 of this gene. Furthermore, BPA induced silencing of BCL2L11 by hypermethylation. This is the first demonstration that BPA induces neoplastic transformation of breast epithelial cells and that aberrant DNA methylation of genes involved in DNA repair and apoptosis could be involved in the initiation of the neoplastic process. Overall design: MCF-10F, a normal-like Homo sapiens breast epithelial cell (HBEC) line that is ERa-negative PR-negative, was maintained in high calcium medium at 37°C and 5% CO2 until confluent. These cells were treated with different concentrations of BPA continuously for two weeks, adding fresh media every day. As controls, MCF-10F cells were not treated and maintained in the regular media or treated with 0.284% DMSO (vehicle). The cells treated with 10-5M or 10-6M BPA after the invasion assay were collected and expanded during 6 passages. DNA was isolated from the cells using a DNA extraction kit (Qiagen)....

Displaying 20 of 26 results for "BARD1"