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Displaying 20 of 22 results for "APOC3"
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  1. Candidate SNPs association with APOC3 BioProject

    ID: PRJNA150977

    Keywords: Variation

    Access Type: download

  2. Candidate SNPs association with APOC3 ArrayExpress

    ID: E-GEOD-34945

    Description: idate SNPs. Association between genotyed SNPs and APOC3 response to therapy was conducted We sought to identify single nucleotide polymorphisms (SNPs) associated with apoC-III level response to combination therapy with statins and fenofibric acid (FA) in individuals with mixed dyslipidemia. Participants in a multicenter, randomized, double-blind, active-controlled study examining response to FA alone and in combination with statin were genotyped for candidate SNPs. Genomic DNA extracted from peripheral blood was genotyped using a custom GoldenGate bead array encompassing 384 SNPs (Illumina). Multivariate linear regression and 2-way ANOVA for percent change in apoC-III level were performed between the groups receiving FA alone compared with FA+statin compared with statin alone....

  3. Candidate SNPs association with APOC3 OmicsDI

    ID: E-GEOD-34945

    Date Released: 07-24-2012

    Description: idate SNPs. Association between genotyed SNPs and APOC3 response to therapy was conducted We sought to identify single nucleotide polymorphisms (SNPs) associated with apoC-III level response to combination therapy with statins and fenofibric acid (FA) in individuals with mixed dyslipidemia. Participants in a multicenter, randomized, double-blind, active-controlled study examining response to FA alone and in combination with statin were genotyped for candidate SNPs. Genomic DNA extracted from peripheral blood was genotyped using a custom GoldenGate bead array encompassing 384 SNPs (Illumina). Multivariate linear regression and 2-way ANOVA for percent change in apoC-III level were performed between the groups receiving FA alone compared with FA+statin compared with statin alone....

  4. Structure and Dynamics of Human Apolipoprotein C-III PDB

    ID: PDB:2JQ3

    Description: Apolipoprotein C-III

    gene.name: APOC3
  5. The transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism ArrayExpress

    ID: E-GEOD-29643

    Description: and concurrent augmentation of the Lpl inhibitor Apoc3. We identified multiple nonsynonymous mutations in CREB3L3 that produced hypomorphic or nonfunctional CREB-H protein in humans with extreme hypertriglyceridemia, implying a crucial role for CREB-H in human triglyceride metabolism. Total RNAs were isolated from the liver of three WT and three Creb3l3 deficient mice after a 24-h fasting. Littermates were used. Gene expression profiles were examined using Illumina WG-6 microarray chips....

  6. The transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism BioProject

    ID: PRJNA141223

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: and concurrent augmentation of the Lpl inhibitor Apoc3. We identified multiple nonsynonymous mutations in CREB3L3 that produced hypomorphic or nonfunctional CREB-H protein in humans with extreme hypertriglyceridemia, implying a crucial role for CREB-H in human triglyceride metabolism. Overall design: Total RNAs were isolated from the liver of three WT and three Creb3l3 deficient mice after a 24-h fasting. Littermates were used. Gene expression profiles were examined using Illumina WG-6 microarray chips....
  7. APOC3_RAT UniProt:Swiss-Prot

    ID: P06759

    Description: Apolipoprotein C-III Lipid-binding Methionine sulfoxide O-linked (GalNAc...)

    gene.name: Apoc3
  8. APOC3_CAVPO UniProt:Swiss-Prot

    ID: Q9Z2R5

    Description: Apolipoprotein C-III Lipid-binding Methionine sulfoxide

    gene.name: APOC3
  9. APOC3_HORSE UniProt:Swiss-Prot

    ID: P0DN28

    Description: Apolipoprotein C-III Lipid-binding

    gene.name: APOC3
  10. APOC3_MACFA UniProt:Swiss-Prot

    ID: P18659

    Description: Apolipoprotein C-III Lipid-binding O-linked (GalNAc...)

    gene.name: APOC3
  11. APOC3_CANLF UniProt:Swiss-Prot

    ID: P12279

    Description: Apolipoprotein C-III Lipid-binding Methionine sulfoxide O-linked (GalNAc...)

    gene.name: APOC3
  12. APOC3_HETGA UniProt:Swiss-Prot

    ID: G5BQH4

    Description: Apolipoprotein C-III Lipid-binding Methionine sulfoxide O-linked (GalNAc...)

    gene.name: Apoc3
  13. APOC3_PANTA UniProt:Swiss-Prot

    ID: P0DMP9

    Description: Apolipoprotein C-III Lipid-binding O-linked (GalNAc...)

    gene.name: APOC3
  14. 9590284 RGD

    Description: SS/JrHsd embryos were microinjected with 1.57 kb human CETP cDNA construct into pSV-SPORT1 with human ApoC3 promoter

    Creators: Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, Rat Resource ...

  15. The transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism OmicsDI

    ID: E-GEOD-29643

    Date Released: 06-02-2014

    Description: and concurrent augmentation of the Lpl inhibitor Apoc3. We identified multiple nonsynonymous mutations in CREB3L3 that produced hypomorphic or nonfunctional CREB-H protein in humans with extreme hypertriglyceridemia, implying a crucial role for CREB-H in human triglyceride metabolism. Total RNAs were isolated from the liver of three WT and three Creb3l3 deficient mice after a 24-h fasting. Littermates were used. Gene expression profiles were examined using Illumina WG-6 microarray chips....

  16. The RNA-binding protein Hdlbp/Vigilin is increased in hepatic steatosis and regulates VLDL secretion through modulation of Apob mRNA translation BioProject

    ID: PRJNA312585

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: oteins such as Apob/apoliproteinB, Ahsg/fetuin-A, Apoc3/apolipoproteinC-III, Fn1/fibronectin, Orm1/orosomucoid and Serpina1/alpha-1-antitrypsin. While mRNA levels of these targets did not change, protein levels were substantially decreased upon knockdown of Vigilin. Hepatic long-term knockdown via GalNAc-conjugated siRNAs ameliorated elevated VLDL/LDL levels and the formation of atherosclerotic plaques in Ldlr–/– mice. These studies uncover a role for Vigilin as a key regulator of hepatic Apob translation and secretion through binding to its mRNA and demonstrate the therapeutic potential of inhibiting Vigilin for cardiovascular diseases. Overall design: PAR-CLIP of Hdlbp/Vigilin and poly(A) selected RNA-sequencing in mouse liver primary hepatocytes...
  17. Multi-omic profiles of human nonalcoholic fatty liver disease tissue highlight heterogenic phenotypes OmicsDI

    ID: MTBLS174

    Date Released: 12-07-2015

    Description: ug toxicity. Additionally, polymorphisms in, e.g. APOC3, PNPLA3, NCAN and PPP1R3B, correlate with NAFLD. Several studies have already investigated later stages of the disease. This study characterizes and stratifies distinct grades of the early steatosis stages of the disease with the aim of identifying mechanisms underlying the etiology of the disease. We analyzed liver biopsies and serum samples from patients with dist...

  18. 2290429 RGD

    Description: SS/JrHsd embryos were microinjected with 1.57 kb human CETP cDNA construct into pSV-SPORT1 with human ApoC3 promoter

    Creators: Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, Rat Resource ...

  19. 8552321 RGD

    Description: olesterylester tansfer protein gene driven by the APOC3 promoter into SHR/Izm rat fertile eggs....

    Creators: National BioResource Project for the Rat in Japan

  20. 8552325 RGD

    Description: The transgenic rats were established by injection of transgene consisting of cholesterylester tansfer protein gene driven by the APOC5 promoter into S...

    Creators: National BioResource Project for the Rat in Japan

    biologicalEntity.identifiers: SHR-Tg(APOC3-CETP)3Tkyo

Displaying 20 of 22 results for "APOC3"