APC2 | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 20 of 32 results for "APC2"
i
  1. Homo sapiens : Homo sapiens Raw sequence reads BioProject

    ID: PRJNA319301

    Keywords: raw sequence reads

    Access Type: download

    dataset.description: th ileal pouch anal anastomosis (IPAA) develop UC-like inflammation ofthe ileal pouch (pouchitis). UC pouchitis is a potential model of UC. We prospectively examinedthe pouch transcriptomes of UC and familial adenomatous polyposis (FAP) IPAA patients tounveil mo...
  2. Gut Microbiome in Inflammatory Complications Following Ileal Pouch - Anal Anastomosis BioProject

    ID: PRJNA217700

    Keywords: Phenotype or Genotype

    Access Type: download

    dataset.description: g surgery for ulcerative colitis (UC) or familial adenomatous polyposis (FAP). Individuals were recruited, with biopsies taken from the ileal pouch and the pre-pouch ileum, microbial DNA was extracted and sequenced using 454 pyrosequencing. Total bacterial...
  3. Homo sapiens : Gut Microbiome in Inflammatory Complications Following Ileal Pouch - Anal Anastomosis BioProject

    ID: PRJNA217699

    Access Type: download

    dataset.description: g surgery for ulcerative colitis (UC) or familial adenomatous polyposis (FAP). Individuals were recruited, with biopsies taken from the ileal pouch and the pre-pouch ileum, microbial DNA was extracted and sequenced using 454 pyrosequencing. Total bacterial...
  4. Structure of an APC2-UBCH10 complex reveals distinctive cullin-RING ligase mechanism for Anaphase-promoting complex/Cyclosome PDB

    ID: PDB:4YII

    Description: molecule, molecule 2

  5. Mount Sinai Hospital (MSH, Toronto, CANADA) pelvic pouch microbiome study dbGaP

    ID: phs000659.v1.p1

    Description: g surgery for ulcerative colitis (UC) or familial adenomatous polyposis (FAP). Individuals were recruited, with biopsies taken from the ileal pouch and the pre-pouch ileum, microbial DNA was extracted and sequenced using 454 pyrosequencing. Total bacterial...

    Study Types: Case-Control

  6. Effect of deletion of the selenium-binding protein 1 gene on gene expression in the ovary of C57BL/6J mouse ArrayExpress

    ID: E-GEOD-36697

    Description: e in myelocytomatosis oncogene and an increase in adenomatosis polyposis coli and tumor necrosis factor. Thus, it is suggested that SeBP1 plays a role in the proliferative and/or anti-proliferative effect via the regulation of these genes. Total RNAs were extracted from the ovaries of wild-type and SeBP1 KO mice at 20 weeks old (each N=3), and their cDNAs were applied to the analysis using Agilent-026655 Whole Mouse Genome Oligo DNA Microarray (4x44K) version 2....

  7. UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density... PDB

    ID: PDB:5L9T

    Description: ex subunit 13, Anaphase-promoting complex subunit 2, Anaphase-promoting complex subunit 5, Fizzy-related protein homolog, HSL1 peptide, UBE2S, Anaphase-promoting complex subunit 7...

  8. Mus musculus : Exome sequencing of iPSC-like cell lines derived from colon tumors in Apc min mouse model BioProject

    ID: PRJDB5450

    Keywords: Exome

    Access Type: download

  9. SNW1 is required for sister chromatid cohesion OmicsDI

    ID: PXD001249

    Date Released: 06-29-2016

    Description: he cohesion protein sororin and the APC/C subunit APC2. SNW1 depletion causes cohesion defects predominantly by reducing sororin levels, which causes destabilisation of cohesin on DNA. SNW1 depletion also reduces APC/C activity and contributes to cohesion defects indirectly by delaying mitosis and causing ‘cohesion fatigue’. Simultaneous expression of sororin and APC2 from intron-less cDNAs restores cohesion in SNW1 depleted cells. These results indicate that the spliceosome is required for mitosis because it enables expression of genes essential for cohesion. Our transcriptome-wide identification of retained introns in SNW1 ...

  10. Molecular characterization of 4-NQO induced F344 rat tongue carcinogenesis: alteration of multiple gene expression and hypomethylation of PTGS2 proxim... BioProject

    ID: PRJNA221235

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: entified 1735 genes to be upregulated by at least 2 fold (p<0.05, n=11) and 1803 genes to be downregulated by at least 50% (p<0.05, n=11) in SCC in comparison to the adjacent normal tissues and 28 KEGG pathways to be altered in SCC (p<0.01). Among the altered genes, keratins and keratin associated proteins were found to be differentially regulated and the keratin profile appeared to an important biomarker for oral SCC. PTGS2 and PTGS2 relevant genes, which are potential targets of chemoprevention and therapy, were also found to be upregulated in SCC and confirmed by qRT-PCR. The upregulation of PTGS2 appeared to correlate with hypomethylation of its proximal promoter. Methylation analysis of other selected genes showed that the first exon of APC2...
  11. Effect of deletion of the selenium-binding protein 1 gene on gene expression in the ovary of C57BL/6J mouse BioProject

    ID: PRJNA153621

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: e in myelocytomatosis oncogene and an increase in adenomatosis polyposis coli and tumor necrosis factor. Thus, it is suggested that SeBP1 plays a role in the proliferative and/or anti-proliferative effect via the regulation of these genes. Overall design: Total RNAs were extracted from the ovaries of wild-type and SeBP1 KO mice at 20 weeks old (each N=3), and their cDNAs were applied to the analysis using Agilent-026655 Whole Mouse Genome Oligo DNA Microarray (4x44K) version 2....
  12. Molecular characterization of 4-NQO induced F344 rat tongue carcinogenesis: alteration of multiple gene expression and hypomethylation of PTGS2 proxim... ArrayExpress

    ID: E-GEOD-51125

    Description: entified 1735 genes to be upregulated by at least 2 fold (p<0.05, n=11) and 1803 genes to be downregulated by at least 50% (p<0.05, n=11) in SCC in comparison to the adjacent normal tissues and 28 KEGG pathways to be altered in SCC (p<0.01). Among the altered genes, keratins and keratin associated proteins were found to be differentially regulated and the keratin profile appeared to an important biomarker for oral SCC. PTGS2 and PTGS2 relevant genes, which are potential targets of chemoprevention and therapy, were also found to be upregulated in SCC and confirmed by qRT-PCR. The upregulation of PTGS2 appeared to correlate with hypomethylation of its proximal promoter. Methylation analysis of other selected genes showed that the first exon of APC2...

  13. Molecular characterization of 4-NQO induced F344 rat tongue carcinogenesis: alteration of multiple gene expression and hypomethylation of PTGS2 proxim... OmicsDI

    ID: E-GEOD-51125

    Date Released: 08-09-2014

    Description: entified 1735 genes to be upregulated by at least 2 fold (p<0.05, n=11) and 1803 genes to be downregulated by at least 50% (p<0.05, n=11) in SCC in comparison to the adjacent normal tissues and 28 KEGG pathways to be altered in SCC (p<0.01). Among the altered genes, keratins and keratin associated proteins were found to be differentially regulated and the keratin profile appeared to an important biomarker for oral SCC. PTGS2 and PTGS2 relevant genes, which are potential targets of chemoprevention and therapy, were also found to be upregulated in SCC and confirmed by qRT-PCR. The upregulation of PTGS2 appeared to correlate with hypomethylation of its proximal promoter. Methylation analysis of other selected genes showed that the first exon of APC2...

  14. Effect of deletion of the selenium-binding protein 1 gene on gene expression in the ovary of C57BL/6J mouse OmicsDI

    ID: E-GEOD-36697

    Date Released: 09-26-2012

    Description: e in myelocytomatosis oncogene and an increase in adenomatosis polyposis coli and tumor necrosis factor. Thus, it is suggested that SeBP1 plays a role in the proliferative and/or anti-proliferative effect via the regulation of these genes. Total RNAs were extracted from the ovaries of wild-type and SeBP1 KO mice at 20 weeks old (each N=3), and their cDNAs were applied to the analysis using Agilent-026655 Whole Mouse Genome Oligo DNA Microarray (4x44K) version 2....

  15. APC2_MOUSE UniProt:Swiss-Prot

    ID: Q9Z1K7

    Description: Adenomatous polyposis coli protein 2 ARM 1 ARM 2 ARM 3 ...

  16. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. PDBe:EMDB

    Types: Image stored as Reals

    Person: Dube P, Herzog F, Peters JM, Stark H

    Release Date: 07-27-2006

  17. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. PDBe:EMDB

    Types: Image stored as Reals

    Person: Dube P, Herzog F, Peters JM, Stark H

    Release Date: 07-28-2006

  18. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. PDBe:EMDB

    Types: Image stored as Reals

    Person: Dube P, Herzog F, Peters JM, Stark H

    Release Date: 07-28-2006

  19. miR-99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGFβ and Wnt signaling OmicsDI

    ID: E-GEOD-56335

    Date Released: 06-03-2014

    Description: ion, downregulation of tumor suppressor genes APC/APC2 stabilizes active β-Catenin and enhances Wnt signaling. By switching the balance between Wnt and TGFβ signaling the concerted action of these tricistronic miRNAs promoted sustained expansion of murine and human HSCs in vitro or in vivo, while favoring megakaryocytic differentiation. We lentivirally transduced cord blood CD34+-hematopoietic stem and progenitor cells (CB-HSPCs) to ectopically express miR-125b-2, miR-99a, let-7c or miR-99a~125b-2 and cultured them in megakaryocytic differentiation medium for 7 days....

  20. Cryo-EM structure of combined apo phosphorylated APC PDB

    ID: PDB:5G05

    Description: EX SUBUNIT 13, ANAPHASE-PROMOTING COMPLEX SUBUNIT 2, ANAPHASE-PROMOTING COMPLEX SUBUNIT 5, UNIDENTIFIED PEPTIDE, ANAPHASE-PROMOTING COMPLEX SUBUNIT 7...


Displaying 20 of 32 results for "APC2"