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Displaying 20 of 1,003 results for "APC"
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  1. Molecular and Family-Based Studies of Gastrointestinal Neoplasia BioProject

    ID: PRJNA282061

    Keywords: Phenotype or Genotype

    Access Type: download

    dataset.description: The ~80% of individuals with classic familial adenomatous polyposis (FAP) have detectable mutations in the coding sequence of the adenomatous
  2. Crystal Structure of the coiled coil region 129-250 of the tumor suppressor gene product APC PDB

    ID: PDB:1M5I

    Description: Adenomatous polyposis coli protein

  3. Homo sapiens : Molecular and Family-Based Studies of Gastrointestinal Neoplasia BioProject

    ID: PRJNA282060

    Access Type: download

    dataset.description: The ~80% of individuals with classic familial adenomatous polyposis (FAP) have detectable mutations in the coding sequence of the adenomatous
  4. Point mutations in exon 1B of APC reveal gastric adenocarcinoma and proximal polyposis of the stomach as a familial adenomatous polyposis variant BioProject

    ID: PRJNA297284

    Keywords: Variation

    Access Type: download

  5. B-catenin deficiency, but not c-Myc deletion, suppresses the immediate phenotypes of Apc loss in the liver ArrayExpress

    ID: E-GEOD-65476

    Description: Using cre lox technology we have deleted the the adenomatous polyposis coli tumour suppressor protein (Apc) within the adult mouse liver and observed a rapid increase in nuclear beta-catenin and C-Myc. This is associated with an induction of proliferation lead...

  6. B-catenin deficiency, but not c-Myc deletion, suppresses the immediate phenotypes of Apc loss in the liver BioProject

    ID: PRJNA274133

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. Transcriptional Profiling of the Transition from Normal Intestine to Adenoma in the APC(Min/+) Mouse BioProject

    ID: PRJNA87749

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer ArrayExpress

    ID: E-GEOD-67186

    Description: The Adenomatous Polyposis Coli (APC) tumor suppressor is mutated in the vast m...

  9. Analysis of colorectal tissue from APC- and MYH-associated polyposis patients ArrayExpress

    ID: E-GEOD-9689

    Description: al cancer cases are triggered by mutations in the APC tumor suppressor gene leading to constitutive activation of the Wnt/b-catenin signaling pathway and adenoma formation. Notwithstanding this common genetic basis, colorectal cancers are very heterogeneous in their degree of differentiation, growth rate and malignant potential. Here, we applied cross-species comparison of expression profiles of intestinal polyps derived from hereditary colorectal cancer patients carrying APC germline mutations, and from a mouse model carrying a ta...

  10. Transcription profiling of liver from wild type and tumor suppressor Apc knock-out mice ArrayExpress

    ID: E-TABM-295

    Description: a duct morphogenesis. Through the inactivation of Apc (adenomatous Polyposis Coli) tumor suppressor gene in hepatoblasts by a Cre-loxP strategy, the ectopic activation of beta-catenin targeted in hepatoblasts after liver bud formation leads to a lethal embryonic phenotype, characterized by liver hypoplasia, a blockade of hepatocyte differentiation and commitment to a biliary fate. (this work was supported by INSERM and the BLigue Na...

  11. Expression Data from 12 week old APCmin/+ and littermate matched Wildtype B6 mouse Terminal Ileum (TI) ArrayExpress

    ID: E-GEOD-49970

    Description: PCmin/+ mice develop spontaneous gastrointestinal polyposis due to a dominantly inhereited germline loss-of-function mutation in the tumor suppressor adenomatous <...

  12. Mus musculus : Exome sequencing of iPSC-like cell lines derived from colon tumors in Apc min mouse model BioProject

    ID: PRJDB5450

    Keywords: Exome

    Access Type: download

  13. Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer BioProject

    ID: PRJNA279201

    Keywords: Transcriptome or Gene expression

    Access Type: download

  14. Altered interactions between the gut microbiome and colonic mucosa precede polyposis in APCMin/+ mice ArrayExpress

    ID: E-GEOD-67634

    Description: Mutation of the adenomatous polyposis coli (APC gene), an early event i...

  15. Analysis of colorectal tissue from APC- and MYH-associated polyposis patients BioProject

    ID: PRJNA103585

    Keywords: Transcriptome or Gene expression

    Access Type: download

  16. Expression Data from 12 week old APCmin/+ and littermate matched Wildtype B6 mouse Terminal Ileum (TI) BioProject

    ID: PRJNA215724

    Keywords: Transcriptome or Gene expression

    Access Type: download

  17. The impact of P53 loss on transcriptome changes following loss of Apc in the intestine ArrayExpress

    ID: E-GEOD-70262

    Description: tivity is known to occur, the importance of these regulatory mechanisms during the early stages of intestinal neoplasia has not been demonstrated. METHODS: We have conditionally deleted the Adenomatous Polyposis coli gene (Apc) from the adult murine intestine in wild type and p53 deficient environments and subsequently compared the phen...

  18. The intestinal adenocarcinomas of the cis-Apc/Smad4 compound mutant mice BioProject

    ID: PRJNA99341

    Keywords: Transcriptome or Gene expression

    Access Type: download

  19. BAC CGH array profiling using Phi29-amplified colon mucosa of microdissected samples from APC and MYH mutation carriers ArrayExpress

    ID: E-GEOD-3898

    Description: J. et al., “Chromosomal instability in MYH- and APC-mutant adenomatous polyps”, Cancer Research, accepted for publication. Abstract of the publication: “The vast majority of colorectal cancers display genetic instabilit...

  20. Transcriptome changes following loss of Apc in the intestine ArrayExpress

    ID: E-GEOD-65461

    Description: alling, predominantly through the mutation of the Apc (Adenomatous Polyposis Coli) gene. Therefore it is of vital importance to elucidate the key Wnt target


Displaying 20 of 1,003 results for "APC"