ANGPT2 | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 20 of 35 results for "ANGPT2"
i
  1. Dual-specificity Fab 5A12 in complex with Angiopoietin 2 PDB

    ID: PDB:4ZFG

    Description: Angiopoietin-2, Fragment antigen binding 5A12 heavy chain, Fragment antigen binding 5A12 light chain

    gene.name: ANGPT2
  2. Delineating the angiogenic gene expression profile prior to pulmonary vascular remodeling in a lamb model of congenital heart disease ArrayExpress

    ID: E-GEOD-22590

    Description: ion of pro-angiogenic genes: FGF2, Angiopoietin2 (Angpt2), and Birc5 at both mRNA and protein levels and the up-regulation of ccl2 at mRNA level in the 3-day shunt lungs. Further, we found that pulmonary arterial endothelial cells (PAEC) isolated from juvenile lambs exhibited increased expression of FGF2, Angpt2, Birc5, and ccl2 as well as enhanced angiogenesis when exposed to elevated shear stress (35 dyn/cm2) compared to cells exposed to more physiological level shear stress (20 dyn/cm2). Finally, we demonstrated that blocking FGF2, Angpt2, or Birc 5 signaling, using neutralizing antibodies, significantly decreased the angiogenic response induced by shear stress. In conclusion, we have identified a pro-angiogenic gene expression profile in a lamb model of CHD with increased PBF that precedes the onset of pulmonary vascular remodeling. Further, our data indicate that FGF2, Angiopoietin2, Birc5, and ccl2 may play important roles in the angiogenic response. Total RNA was isolated from the lungs of Shunt and Control lambs at 3 days of age and hybridized to Affymetrix GeneChips for microarray analyses. Eight chips were employed...

  3. Delineating the angiogenic gene expression profile prior to pulmonary vascular remodeling in a lamb model of congenital heart disease BioProject

    ID: PRJNA128391

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ion of pro-angiogenic genes: FGF2, Angiopoietin2 (Angpt2), and Birc5 at both mRNA and protein levels and the up-regulation of ccl2 at mRNA level in the 3-day shunt lungs. Further, we found that pulmonary arterial endothelial cells (PAEC) isolated from juvenile lambs exhibited increased expression of FGF2, Angpt2, Birc5, and ccl2 as well as enhanced angiogenesis when exposed to elevated shear stress (35 dyn/cm2) compared to cells exposed to more physiological level shear stress (20 dyn/cm2). Finally, we demonstrated that blocking FGF2, Angpt2, or Birc 5 signaling, using neutralizing antibodies, significantly decreased the angiogenic response induced by shear stress. In conclusion, we have identified a pro-angiogenic gene expression profile in a lamb model of CHD with increased PBF that precedes the onset of pulmonary vascular remodeling. Further, our data indicate that FGF2, Angiopoietin2, Birc5, and ccl2 may play important roles in the angiogenic response. Overall design: Total RNA was isolated from the lungs of Shunt and Control lambs at 3 days of age and hybridized to Affymetrix GeneChips for microarray analyses. Eight chi...
  4. Delineating the angiogenic gene expression profile prior to pulmonary vascular remodeling in a lamb model of congenital heart disease OmicsDI

    ID: E-GEOD-22590

    Date Released: 06-02-2014

    Description: ion of pro-angiogenic genes: FGF2, Angiopoietin2 (Angpt2), and Birc5 at both mRNA and protein levels and the up-regulation of ccl2 at mRNA level in the 3-day shunt lungs. Further, we found that pulmonary arterial endothelial cells (PAEC) isolated from juvenile lambs exhibited increased expression of FGF2, Angpt2, Birc5, and ccl2 as well as enhanced angiogenesis when exposed to elevated shear stress (35 dyn/cm2) compared to cells exposed to more physiological level shear stress (20 dyn/cm2). Finally, we demonstrated that blocking FGF2, Angpt2, or Birc 5 signaling, using neutralizing antibodies, significantly decreased the angiogenic response induced by shear stress. In conclusion, we have identified a pro-angiogenic gene expression profile in a lamb model of CHD with increased PBF that precedes the onset of pulmonary vascular remodeling. Further, our data indicate that FGF2, Angiopoietin2, Birc5, and ccl2 may play important roles in the angiogenic response. Total RNA was isolated from the lungs of Shunt and Control lambs at 3 days of age and hybridized to Affymetrix GeneChips for microarray analyses. Eight chips were employed...

  5. Gene expression changes during development of sunitinib resistance in renal cell carcinoma patient derived xenografts ArrayExpress

    ID: E-GEOD-76068

    Description: ed with increased expression of VEGFA, EPO, IL-8, ANGPT2, TNFRSF12, MAPK3/7, MAPKBP1, and increased cell survival genes, suggesting activation of angiogenesis and MAPK/ERK pathways. Tumor lysate mRNA evaluated for murine gene expression to examine the contribution of host effects, indicated that tumor response was associated with downregulation of immune cell trafficking, cellular movement, and inflammatory response genes. During tumor escape, genes associated with cellular movement, inflammatory response, and immune cell trafficking were strongly induced, along with intratumoral accumulation of myeloid derived suppressor cells (MDSC), indicating a role for host factors during emergence of sunitinib resistance. The same PDX model was used to assess anti-tumor efficacy of sunitinib combined with MEK inhibitor (MEKi) PD...

  6. ANGP2_PIG UniProt:Swiss-Prot

    ID: Q9BDY7

    Description: Angiopoietin-2 Fibrinogen C-terminal Calcium Calcium Calcium; via carbonyl oxygen Calcium; via carbonyl oxygen N-linked (GlcNAc...) N-linked (GlcNAc.....

    gene.name: ANGPT2
  7. ANGP2_CANLF UniProt:Swiss-Prot

    ID: A0A8J8

    Description: Angiopoietin-2 Fibrinogen C-terminal Calcium Calcium Calcium; via carbonyl oxygen Calcium; via carbonyl oxygen N-linked (GlcNAc...) N-linked (GlcNAc.....

    gene.name: ANGPT2
  8. Dual angiopoietin-2 and VEGFA inhibition elicits anti-tumor immunity that is enhanced by PD1 checkpoint blockade BioProject

    ID: PRJNA374860

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: elial growth factor-A (VEGFA) and angiopoietin-2 (ANGPT2) sustain tumor angiogenesis and limit anti-tumor immunity. Here we show that combined ANGPT2 and VEGFA blockade by a bi-specific antibody (A2V) provided synergistic anti-tumoral benefits in tran...
  9. Angiopoietin-2 fibrinogen domain TAG mutant PDB

    ID: PDB:4JZC

    Description: Angiopoietin-2

    gene.name: ANGPT2
  10. Uncrossed Fab binding to human Angiopoietin 2 PDB

    ID: PDB:4IMK

    Description: Heavy Chain, Light Chain

  11. CrossFab binding to human Angiopoietin 2 PDB

    ID: PDB:4IML

    Description: Crossed heavy chain (VH-Ckappa), Crossed light chain (VL-CH1)

  12. RNA-seq of Tumor-associated Endothelial Cells from Different Immunodeficient Backgrounds BioProject

    ID: PRJNA353109

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ways that affect vessel maturation (VEGFA, ANGPT1/ANGPT2, TGFbR, and sphingolipid metabolism), we ran Gene Set Enrichment Analysis (GSEA) and found a down-regulation of cellular adhesion and extracellular matrix assembly-related pathways in the CD4 T cell deficient group. This suggests that CD4+ T cells play an important role in promoting tumor vessel integrity and normalization. Overall design: Tra...
  13. Prospective gene expression analysis of human RNA samples from Hepatocellular Carcinoma in relation with growth rate and survival ArrayExpress

    ID: E-GEOD-54236

    Description: of the same patients. Expression of five genes (ANGPT2, NETO2,NR4A1,DLL4,ESM1) from this signature was re-evaluated in a validation cohort by real-time PCR, confirming its correlation with growth rate and survival. The bioinformatical analysis of 161 microarray datasets were obtained from single color hybridization of human RNAs on Agilent Whole Human Genome Oligo Microarrays after T7 RNA amplification. For the purpose of this study, two discriminatory gene sets analysis were performed: up-regulated and down regulated in fast-growing tumo...

  14. Prospective gene expression analysis of human RNA samples from Hepatocellular Carcinoma in relation with growth rate and survival OmicsDI

    ID: E-GEOD-54236

    Date Released: 06-03-2014

    Description: of the same patients. Expression of five genes (ANGPT2, NETO2,NR4A1,DLL4,ESM1) from this signature was re-evaluated in a validation cohort by real-time PCR, confirming its correlation with growth rate and survival. The bioinformatical analysis of 161 microarray datasets were obtained from single color hybridization of human RNAs on Agilent Whole Human Genome Oligo Microarrays after T7 RNA amplification. For the purpose of this study, two discriminatory gene sets analysis were performed: up-regulated and down regulated in fast-growing tumo...

  15. Using Oligo Array Analysis to Determine Genes of Importance in the Meninges and Associated Vasculature Function and their Sensitivity to Amphetamine T... BioProject

    ID: PRJNA131873

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: V. Esam increased with AMPH in all regions while Angpt2 was only affected in striatum and parietal cortex. It is not known how these changes affect MAV, striatum or parietal cortex tight junction function/BBB and integrity. Overall design: Gene expression patterns in MAV were compared to two regions of brain (striatum and parietal cortex) to identify genes important to MAV function and determine whether their expressions were sensitive to a neurotoxic exposure to amphetamine....
  16. Gene expression changes during development of sunitinib resistance in renal cell carcinoma patient derived xenografts BioProject

    ID: PRJNA306151

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ed with increased expression of VEGFA, EPO, IL-8, ANGPT2, TNFRSF12, MAPK3/7, MAPKBP1, and increased cell survival genes, suggesting activation of angiogenesis and MAPK/ERK pathways. Tumor lysate mRNA evaluated for murine gene expression to examine the contribution of host effects, indicated that tumor response was associated with downregulation of immune cell trafficking, cellular movement, and inflammatory response genes. During tumor escape, genes associated with cellular movement, inflammatory response, and immune cell trafficking were strongly induced, along with intratumoral accumulation of myeloid derived suppressor cells (MDSC), indicating a role for host factors during emergence of sunitinib resistance. The same PDX model was used to assess anti-tumor efficacy of sunitinib combined with MEK inhibitor (MEKi) PD...
  17. Gene expression changes during development of sunitinib resistance in renal cell carcinoma patient derived xenografts OmicsDI

    ID: E-GEOD-76068

    Date Released: 12-18-2015

    Description: ed with increased expression of VEGFA, EPO, IL-8, ANGPT2, TNFRSF12, MAPK3/7, MAPKBP1, and increased cell survival genes, suggesting activation of angiogenesis and MAPK/ERK pathways. Tumor lysate mRNA evaluated for murine gene expression to examine the contribution of host effects, indicated that tumor response was associated with downregulation of immune cell trafficking, cellular movement, and inflammatory response genes. During tumor escape, genes associated with cellular movement, inflammatory response, and immune cell trafficking were strongly induced, along with intratumoral accumulation of myeloid derived suppressor cells (MDSC), indicating a role for host factors during emergence of sunitinib resistance. The same PDX model was used to assess anti-tumor efficacy of sunitinib combined with MEK inhibitor (MEKi) PD...

  18. The Calcineurin-NFAT-Angiopoietin 2 signaling axis in lung endothelium is critical for the establishment of lung metastases ArrayExpress

    ID: E-GEOD-48841

    Description: The pre-metastatic niche is a pre-determined site of metastases, awaiting the influx of tumor cells. Here we demonstrate that the calcineurin-NFAT pat...

  19. Altered Gene Expression Profile in Ovarian Follicle in Rats Treated with Indomethacin and RU486 BioProject

    ID: PRJNA237063

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ). Down-regulation of angiogenesis related genes (Angpt2, Hmox1, and Vegfa) was observed in both treatment groups. Here, we clarify genetic alterations induced by the inhibition of cyclooxygenase or progesterone receptor. Overall design: Animals were singly administered orally 4mg/kg of Indomethacin (IM) at 16:00 or 100 mg/kg of RU486 (RU) at 10:00 on the proestrus day, and sacrificed by exsanguination under anesthesia at 22:00 on the proestrus day, and 10:00 on the following estrus day. Three animals were contained per each treatment group at each timing. Pre-ovulatory follicle (PeF) and unruptured follicles (UF) were laser-microdissected from ovaries collected on the proestrus day, and the estrus day, respectively. From untreated animals, PeF and post-ovulatory follicle (PoF) were also laser-microdissected from the ovaries collected on the proestrus day, and the estrus day, respectively, as the control group. The ovaries were removed and embedded in OCT (Tissue-Tek, Sakura Finetek, Torrance, CA), frozen in dry-ice-cold isopentan, and stored at -70 °C until used. Frozen sections (8 micro meter thick) were mounted on the membrane slides (MMI, Glatteburg, Zurich, Switzerland), and stained with HistogeneTM LCM frozen section staining kit (Arcturus Engineering, Mountain View, CA). Then, 15 follicles in each phase were retrieved by Laser Micro Dissection system (LMD, CellCut Plus®, MMI). The collected follicle sections were lysed by the buffer RLT in the collection tube supplied in RNeasy Micro Kit (Qiagen, Hild...
  20. MEMA YAPC Staining Set 3 LINCS

    Data Type: Imaging Cytological profile

    Assay: MEMA cell growth assay

    Biological Process: Cell proliferation

    ID: LDS-1335

    protein.name: ANGPT2|1_O15123|1

Displaying 20 of 35 results for "ANGPT2"