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Displaying 20 of 27 results for "ALDH3A1"
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  1. Crystal structure of human ALDH3A1 with its isozyme selective inhibitor - N-[4-(4-methylsulfonyl-2-nitroanilino)phenyl]acetamide PDB

    ID: PDB:4H80

    Description: Aldehyde dehydrogenase, dimeric NADP-preferring (E.C.1....

  2. Crystal structure of human ALDH3A1 - apo form PDB

    ID: PDB:3SZA

    Description: Aldehyde dehydrogenase, dimeric NADP-preferring (E.C.1....

  3. AL3A1_BOVIN UniProt:Swiss-Prot

    ID: P30907

    Description: Aldehyde dehydrogenase, dimeric NADP-preferring

  4. AL3A1_RAT UniProt:Swiss-Prot

    ID: P11883

    Description: Removed Aldehyde dehydrogenase, dimeric NADP-preferring NAD or ...

  5. AL3A1_CANLF UniProt:Swiss-Prot

    ID: A3RF36

    Description: Removed Aldehyde dehydrogenase, dimeric NADP-preferring NAD or ...

  6. AL7A1_BRANA UniProt:Swiss-Prot

    ID: Q41247

    Description: Removed Aldehyde dehydrogenase family 7 member A1 NAD Proton ac...

  7. AL7A1_MALDO UniProt:Swiss-Prot

    ID: Q9ZPB7

    Description: Removed Aldehyde dehydrogenase family 7 member A1 NAD Proton ac...

  8. AL7A1_PEA UniProt:Swiss-Prot

    ID: P25795

    Description: Removed Aldehyde dehydrogenase family 7 member A1 NAD Proton ac...

  9. Gene Expression Profiling in A549 Lung Cancer Cell Line Following siRNA Mediated Knock-down of ALDH1A1 and ALDH3A1 BioProject

    ID: PRJNA100867

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. Crystal structure of human ALDH3A1 with its selective inhibitor 1-(4-fluorophenyl)sulfonyl-2-methylbenzimidazole PDB

    ID: PDB:4L2O

    Description: Aldehyde dehydrogenase (E.C.1.2.1.5)

  11. siRNA profiling of human A549 lung cancer cell line following siRNA mediated knock-down of ALDH1A1 and ALDH3A1 ArrayExpress

    ID: E-GEOD-8045

    Description: Aldehyde dehydrogenase isozymes ALDH1A1 and ALDH3A1 are highly expressed in non small cell ce...

  12. Crystal structure of human ALDH3A1 modified with the beta-elimination product of Aldi-1; 1-phenyl- 2-propen-1-one PDB

    ID: PDB:3SZB

    Description: Aldehyde dehydrogenase (E.C.1.2.1.5)

  13. Crystal structure of human ALDH3A1 with inhibitor 1-{[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]methyl}-1H-indole-2,3-dione PDB

    ID: PDB:4L1O

    Description: Aldehyde dehydrogenase (E.C.1.2.1.5)

  14. siRNA profiling of human A549 lung cancer cell line following siRNA mediated knock-down of ALDH1A1 and ALDH3A1 OmicsDI

    ID: E-GEOD-8045

    Date Released: 06-10-2011

    Description: Aldehyde dehydrogenase isozymes ALDH1A1 and ALDH3A1 are highly expressed in non small cell ce...

  15. Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane treated human breast epithelial cells BioProject

    ID: PRJNA138799

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: c and proteomic analyses. The aldo-keto reductase family members, AKR1B10, AKR1C1, AKR1C2 and AKR1C3, as well as NQO1 and ALDH3A1, were highly upregulated at both the transcriptomic and proteomic level. Collectively, these studies served to identify potential biomarkers that can be used in clinical trials to investigate the initial pharmacodynamic action of SFN in the breast. Overall design: MCF10A cells were treated with SFN or had KEAP1 knocked down by siRNA....
  16. ALTERATIONS IN THE SPUTUM PROTEOME AND TRANSCRIPTOME IN SMOKERS AND EARLY-STAGE COPD PATIENTS ArrayExpress

    ID: E-MTAB-3604

    Description: obiotic/oxidative stress response (e.g., NQO1 and ALDH3A1 up-regulation). The latter response also was observed in the sputum transcriptome, which additionally demonstrated an immune-related polarization change (toward a M2 signature). The (long-term) former smoker group showed nearly complete reversal of the observable biological effects. Thirteen differentially abundant proteins between the COPD and healthy smoker groups were identified. These abundant proteins included previously reported COPD-associated proteins (e.g., TIMP1 (up-regulation) and APOA1 (down-regulation)) and novel proteins such as C6orf58 and BPIFB1 (LPLUNC1) (both up-regulated in the COPD group compared with the healthy smokers). In summary, our study demonstrates that sputum proteomics/transcriptomics can capture the complex and reversible physiological response to cigarette smoke exposure, which appears to be only slightly modulated in early-stage COPD patients. The study has been registered on ClinicalTrials.gov with identifier NCT01780298....

  17. Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane treated human breast epithelial cells ArrayExpress

    ID: E-GEOD-28813

    Description: c and proteomic analyses. The aldo-keto reductase family members, AKR1B10, AKR1C1, AKR1C2 and AKR1C3, as well as NQO1 and ALDH3A1, were highly upregulated at both the transcriptomic and proteomic level. Collectively, these studies served to identify potential biomarkers that can be used in clinical trials to investigate the initial pharmacodynamic action of SFN in the breast. MCF10A cells were treated with SFN or had KEAP1 knocked down by siRNA....

  18. Patterns of dioxin-altered mRNA expression in livers of dioxin-sensitive versus dioxin-resistant rats ArrayExpress

    ID: E-GEOD-13513

    Description: s tested, including CYP1A1, CYP1A2, CYP1B1, Nqo1, Aldh3a1, Tiparp, Exoc3, and Inmt. Outside this core, the strains differed significantly in the breadth of response: three-fold more genes were altered in L-E than H/W rats. At ten days almost all expressed genes were dysregulated in L-E rats, likely reflecting emerging toxic responses. Far fewer genes were affected by feed-restriction, suggesting that only a minority of the TCDD-induced changes are secondary to the wasting syndrome. Rats from sensitive (Long-Evans, LE) and resistant (Han/Wistar, HW) strains were treated with 100 ug/kg TCDD or corn oil vehicle and sacrificed either 4 or 10 days after treatment. LE control rats were either fed normally or feed-restricted to control for the wasting effects of TCDD treatment. Each treatment group contains four or five animals (biological replicates), each of which was assayed on an individual microarray....

  19. Compound mouse mutants of bZIP transcription factors MafG and MafK reveal a regulatory network of non-crystallin genes linled to cataract ArrayExpress

    ID: E-GEOD-65500

    Description: tory partners, 2) iSyTE lens-expression data, and 3) interactions between DRGs in the String database, unravels a detailed small Maf regulatory network in the lens, several nodes of which are linked to human cataract. This analysis prioritizes 36 highly promising candidates from the original 97 DRGs. Significantly, 8/36 (22%) DRGs are associated with cataracts in human (GSTO1, MGST1, SC4MOL, UCHL1) or mouse (Aldh3a1, Crygf, Hspb1, Pcbd1), suggesting a multifactorial etiology that includes elevation of oxidative stress. These data identify MafG and MafK as new cataract-associated candidates and define their function in regulating largely non-crystallin genes linked to mouse and human cataract. Microarray comparision of lenses from mixed background (129Sv/J, C57BL/6J, and ICR) control (MafG+/-:MafK+/-; no-cataract) and compound (MafG-/-:MafK+/-; cataract) mouse mutants...

  20. Compound mouse mutants of bZIP transcription factors MafG and MafK reveal a regulatory network of non-crystallin genes linled to cataract BioProject

    ID: PRJNA274227

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: tory partners, 2) iSyTE lens-expression data, and 3) interactions between DRGs in the String database, unravels a detailed small Maf regulatory network in the lens, several nodes of which are linked to human cataract. This analysis prioritizes 36 highly promising candidates from the original 97 DRGs. Significantly, 8/36 (22%) DRGs are associated with cataracts in human (GSTO1, MGST1, SC4MOL, UCHL1) or mouse (Aldh3a1, Crygf, Hspb1, Pcbd1), suggesting a multifactorial etiology that includes elevation of oxidative stress. These data identify MafG and MafK as new cataract-associated candidates and define their function in regulating largely non-crystallin genes linked to mouse and human cataract. Overall design: Microarray comparision of lenses from mixed background (129Sv/J, C57BL/6J, and ICR) control (MafG+/-:MafK+/-; no-cataract) and compound (MafG-/-:MafK+/-; cataract) mouse mutants...

Displaying 20 of 27 results for "ALDH3A1"