The SEC family of RNA Polymerase II elongation factors: gene target specificity and transcriptional output BioProject

ID: PRJNA149901

Keywords: Other

Access Type: download

The SEC family of RNA Polymerase II elongation factors: gene target specificity and transcriptional output ArrayExpress

ID: E-GEOD-34097

Description: ike 2 (SEC-L2) and SEC-like 3 (SEC-L3) containing AFF2 and AFF3 in association with P-TEFb, ENL, and AF9. The SEC family members demonstrate high levels of Pol II CTD kinase activity, however, only SEC is required for the proper induction of the HSP70 gene upon stress. Genome-wide mRNA-seq analyses demonstrate that SEC-L2-3 control the expression of different subsets of genes, while AFF4/SEC plays a more dominant role in rapid gene expressi...

The SEC family of RNA Polymerase II elongation factors: gene target specificity and transcriptional output OmicsDI

ID: E-GEOD-34097

Date Released: 05-04-2014

Description: ike 2 (SEC-L2) and SEC-like 3 (SEC-L3) containing AFF2 and AFF3 in association with P-TEFb, ENL, and AF9. The SEC family members demonstrate high levels of Pol II CTD kinase activity, however, only SEC is required for the proper induction of the HSP70 gene upon stress. Genome-wide mRNA-seq analyses demonstrate that SEC-L2-3 control the expression of different subsets of genes, while AFF4/SEC plays a more dominant role in rapid gene expressi...

t (Cc+Af) or A. frigida fractions (Cc+AfF1 and Cc+AfF2).... Figshare

ID: doi:10.6084/M9.FIGSHARE.3565599

Release Date: 09-30-2016

Description: t (Cc+Af) or A. frigida fractions (Cc+AfF1 and Cc+AfF2)....

t (Cc+Af) or A. frigida fractions (Cc+AfF1 and Cc+AfF2).... Figshare

ID: doi:10.6084/M9.FIGSHARE.3565599.V1

Release Date: 09-30-2016

Description: t (Cc+Af) or A. frigida fractions (Cc+AfF1 and Cc+AfF2)....

Reduction in nuclear speckles and transcriptome de-regulation in fibroblast of intellectually disabled patients with mutations at the FRAXE site ArrayExpress

ID: E-GEOD-27953

Description: Loss of function of FMR2 due to either hypermethylation of the CpG island as a consequence of the expansion of the CCG repeat near its transcription s...

Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4 PDB

ID: PDB:4OR5

Description: Cyclin-dependent kinase 9 (E.C.2.7.11.22, 2.7.11.23), Cyclin-T1, Protein Tat, AF4/FMR2 family member 4

The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat PDB

ID: PDB:4IMY

Description: Cyclin-dependent kinase 9 (E.C.2.7.11.22, 2.7.11.23), Cyclin-T1, AF4/FMR2 family member 4

Solution structure of the AF4-AF9 complex PDB

ID: PDB:2LM0

Description: AF4/FMR2 family member 1/Protein AF-9 chimera

crystal structure of P-TEFb complex with AFF4 and Tat PDB

ID: PDB:4OGR

Description: Cyclin-dependent kinase 9 (E.C.2.7.11.22, 2.7.11.23), Cyclin-T1, AF4/FMR2 family member 4, Protein Tat

Detection of Clinically Relevant Genetic Variants in Autism Spectrum Disorder by Whole-Genome Sequencing OmicsDI

ID: EGAS00001000850

Date Released:

Description: date ASD risk genes. Examples include CAPRIN1 and AFF2 (both linked to FMR1, which is involved in fragileX syndrome), VIP (involved in social-cognitive deficits), and other genes such as SCN2A and KCNQ2 (linked to epilepsy), NRXN1, andCHD7, which causes ASD-associated CHARGE syndrome. Taken together, these results suggest that WGS and thorough bioinformaticanalyses for de novo and rare inherited mutations will improve the detection of genetic variants likely to be associated with ASD orits accompanying clinical symptoms....

TAR complex with HIV-1 Tat-AFF4-P-TEFb PDB

ID: PDB:5L1Z

Description: Cyclin-dependent kinase 9, Cyclin-T1, AF4/FMR2 family member 4, Protein Tat/RNA Complex

Reduction in nuclear speckles and transcriptome de-regulation in fibroblast of intellectually disabled patients with mutations at the FRAXE site BioProject

ID: PRJNA137735

Keywords: Transcriptome or Gene expression

Access Type: download