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Displaying 20 of 28 results for "ADCY7"
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  1. ter adipogenic differentation, and after chronic adenylate cyclase activation of differentiated cells... BioProject

    ID: PRJNA296865

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Transcription Factor CHF1/Hey2 Regulates Specific Gene Sets in Serum Stimulated Primary Cardiac Myocytes BioProject

    ID: PRJNA111285

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: e sets involved in water transport, regulation of adenylate cyclase activity, embryonic eye morphogenesis, gut development and fluid transport after serum stimulation. Genes involved in protein dephosphorylation, in contrast, demonstrate increased expression in myocytes overexpressing CHF1/Hey2, and this increase is independent of serum treatment. Genes overexpressed prior to serum treatment are involved in regulation of transcription factor activity, protein export from the nucleus, and steroid hormone receptor signaling. Genes overexpressed after serum treatment are involved in autophagy, apoptosis and mitochondrial biogenesis. Conclusions: CHF1/Hey2 suppresses fluid transport, activation of adenylate cyclase activity, promotes phosphatase activity, autophagy and regulates other important biological processes likely relevant to hypertrophy. Overall design: Transgenic Mice and Neonatal Mouse Myocyte Culture...
  3. ter adipogenic differentation, and after chronic adenylate cyclase activation of differentiated cells... ArrayExpress

    ID: E-GEOD-73385

    Description: ing which they were stimulated with forskolin for 7 days Microarrays were used to detail the program of differentiation of thermogenic human adipose cells Adipose tissue from three individuals was cultured in hydrogel under pro-angiogenic conditions. Capillary networks emerging from the explants...

  4. Transcription Factor CHF1/Hey2 Regulates Specific Gene Sets in Serum Stimulated Primary Cardiac Myocytes ArrayExpress

    ID: E-GEOD-14288

    Description: e sets involved in water transport, regulation of adenylate cyclase activity, embryonic eye morphogenesis, gut development and fluid transport after serum stimulation. Genes involved in protein dephosphorylation, in contrast, demonstrate increased expression in myocytes overexpressing CHF1/Hey2, and this increase is independent of serum treatment. Genes overexpressed prior to serum treatment are involved in regulation of transcription factor activity, protein export from the nucleus, and steroid hormone receptor signaling. Genes overexpressed after serum treatment are involved in autophagy, apoptosis and mitochondrial biogenesis. Conclusions: CHF1/Hey2 suppresses fluid transport, activation of adenylate cyclase activity, promotes phosphatase activity, autophagy and regulates other important biological processes likely relevant to hypertrophy. Transgenic Mice and Neonatal Mouse Myocyte Culture: WT no serum, 5...

  5. KLF2-Regulated Gene Expression in Mouse Embryonic Yolk Sac Erythroid Cells ArrayExpress

    ID: E-GEOD-27602

    Description: ythroid-enriched regulatory genes such as reelin, adenylate cyclase 7, cytotoxic T lymphocyte-associated protein 2 alpha, and CD24a antigen are downregulated in KLF2-/- compared to WT. SOX2, a pluripotency factor in ES cells, is also a KLF2 target in embryonic erythroid cells. We investigated whether reelin, which has an established role in neuronal migration and proliferation, has a role in embryonic erythropoiesis. Luciferase reporter assays demonstrated that KLF2 directly transactivates the reelin promoter, but reelin mutant mice have no apparent abnormalities in embryonic erythroid morphology or globin gene expression. Timed-pregnant KLF2+/- females were anesthetized and sacrificed. E9.5 yolk sacs were dissected from the embryo, cryoprotected in 20% sucrose in PBS and frozen in OCT media. A small portion of the embryo tail was used for PCR genotyping. Eight micron KLF2-/- frozen yolk sac sections were obtained and laser capture micr...

  6. CYAA_PODAS UniProt:Swiss-Prot

    ID: Q01513

    Description: Adenylate cyclase Ras-associating LRR 1 LRR 2 LRR 3 LRR 4 LRR 5 LRR 6 LRR 7 LRR 8 LRR 9 LRR 1...

  7. CYAA_SCHPO UniProt:Swiss-Prot

    ID: P14605

    Description: Adenylate cyclase Ras-associating LRR 1 LRR 2 LRR 3 LRR 4 LRR 5 LRR 6 LRR 7 LRR 8 LRR 9 LRR 1...

  8. CYAA_LACKL UniProt:Swiss-Prot

    ID: P23466

    Description: Adenylate cyclase Ras-associating LRR 1 LRR 2 LRR 3 LRR 4 LRR 5 LRR 6 LRR 7 LRR 8 LRR 9 LRR 1...

  9. Transcription Factor CHF1/Hey2 Regulates Specific Gene Sets in Serum Stimulated Primary Cardiac Myocytes OmicsDI

    ID: E-GEOD-14288

    Date Released: 06-10-2011

    Description: e sets involved in water transport, regulation of adenylate cyclase activity, embryonic eye morphogenesis, gut development and fluid transport after serum stimulation. Genes involved in protein dephosphorylation, in contrast, demonstrate increased expression in myocytes overexpressing CHF1/Hey2, and this increase is independent of serum treatment. Genes overexpressed prior to serum treatment are involved in regulation of transcription factor activity, protein export from the nucleus, and steroid hormone receptor signaling. Genes overexpressed after serum treatment are involved in autophagy, apoptosis and mitochondrial biogenesis. Conclusions: CHF1/Hey2 suppresses fluid transport, activation of adenylate cyclase activity, promotes phosphatase activity, autophagy and regulates other important biological processes likely relevant to hypertrophy. Transgenic Mice and Neonatal Mouse Myocyte Culture: WT no serum, 5...

  10. PACR_BOVIN UniProt:Swiss-Prot

    ID: Q29627

    Description: Pituitary adenylate cyclase-activating polypeptide type I receptor Extracellular Helical; Name=1 Cytoplasmic Helical; Name...

  11. ESA8C_TRYEQ UniProt:Swiss-Prot

    ID: P26337

    Description: Putative adenylate cyclase regulatory protein LRR 1 LRR 2 LRR 3 LRR 4 LRR 5 LRR 6 LRR 7 LRR 8 LRR 9 LR...

  12. PACR_MOUSE UniProt:Swiss-Prot

    ID: P70205

    Description: Pituitary adenylate cyclase-activating polypeptide type I receptor Extracellular Helical; Name=1 Cytoplasmic Helical; Name...

  13. ESAG8_TRYBB UniProt:Swiss-Prot

    ID: P23799

    Description: Putative adenylate cyclase regulatory protein LRR 1 LRR 2 LRR 3 LRR 4 LRR 5 LRR 6 LRR 7 LRR 8 LRR 9 LR...

  14. PTHRP/Adenylate cyclase promotes parietal whereas Wnt/β-catenin signaling promotes visceral endoderm differentiation of rat XEN cells. BioProject

    ID: PRJNA181969

    Keywords: Transcriptome or Gene expression

    Access Type: download

  15. PTHRP/Adenylate cyclase promotes parietal whereas Wnt/β-catenin signaling promotes visceral endoderm differentiation of rat XEN cells ArrayExpress

    ID: E-GEOD-42438

    Description: s control, (4-6) 2 days treated with CHIR alone, (7-9) 1 day treated with CHIR and 1 day with both CHIR and forskolin, and (10-12) 1 day treated with forskolin alone. In all samples on DAY1 cells were plated, at DAY2 cells were cultured in usual conditions (DMEM F12 medium and 10% Fetal Bovine Serum, both from Sigma) and inhibitor of GSK3 kinase 3 μM CHIR99021 (Axon Medchem) was added in samples 4-9. On DAY3 all cells were cultured in medium with 0.1% serum to exclude the influence of serum and in CONTROL (1-3) cells were cultured without experimental treatments, in CHIR (4-6) cells were further cultured with 3 μM CHIR99021, in CHIR plus FORSKOLIN cells were cultured with 3 μM CHIR99021 and 10μM Forskolin (Sigma), in FORSKOLIN cells were cultured for 1 day with 10 μM Forskolin. On DAY4 RNA was isolated....

  16. ter adipogenic differentation, and after chronic adenylate cyclase activation of differentiated cells... OmicsDI

    ID: E-GEOD-73385

    Date Released: 01-10-2016

    Description: ing which they were stimulated with forskolin for 7 days Microarrays were used to detail the program of differentiation of thermogenic human adipose cells Adipose tissue from three individuals was cultured in hydrogel under pro-angiogenic conditions. Capillary networks emerging from the explants...

  17. 20150422-AC7-AC1809_S5_R1 Dryad

    DateIssued: 03-18-2016

    Description: ACLYinh rep1

  18. -Arg389 and beta1-Gly389 receptors, or AC5 adenyl cyclase - differential cardiac gene regulation by Arg- and Gly389 polymorphic forms of the beta1-adrenergic receptor... ArrayExpress

    ID: E-GEOD-11887

    Description: le to pathways beyond that of classic Gs-adenylyl cyclase (AC)/cAMP signaling, we performed comparative gene expression profile analyses on hearts from wildtype and transgenic mice that expressed either human beta1-Arg389 and beta1-Gly389 receptors, or AC5 adenyl cyclase, sampling at an early age and stage, prior to the onset of pathologic features. We observed substantial overlap of dysregulated genes across all three transgenic h...

  19. KLF2-Regulated Gene Expression in Mouse Embryonic Yolk Sac Erythroid Cells BioProject

    ID: PRJNA138277

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ythroid-enriched regulatory genes such as reelin, adenylate cyclase 7, cytotoxic T lymphocyte-associated protein 2 alpha, and CD24a antigen are downregulated in KLF2-/- compared to WT. SOX2, a pluripotency factor in ES cells, is also a KLF2 target in embryonic erythroid cells. We investigated whether reelin, which has an established role in neuronal migration and proliferation, has a role in embryonic erythropoiesis. Luciferase reporter assays demonstrated that KLF2 directly transactivates the reelin promoter, but reelin mutant mice have no apparent abnormalities in embryonic erythroid morphology or globin gene expression. Overall design: Timed-pregnant KLF2+/- females were anesthetized and sacrificed. E9.5 yolk sacs were dissected from the embryo, cryoprotected in 20% sucrose in PBS and frozen in OCT media. A small portion of the embryo tail was used for PCR genotyping. Eight micron KLF2-/- frozen yolk sac sections were obtained and la...
  20. Fatigue-related HIV disease gene-networks identified in CD14+ cells isolated from HIV-infected patients OmicsDI

    ID: E-GEOD-18468

    Date Released: 06-10-2011

    Description: tive of HIV status. A surprising finding was that adenylate cyclase 2 (ADCY2) was a predictor of both HIV and fatigue; it had the highest Kendall’s Tau association value in the HIV group, but in reverse, the lowest Tau value in the fatigue group. Assaying CD14+ cells may provide an alternative to muscle biopsy and a minimally invasive procedure to evaluate patient mitochondrial function, and Bayesian and network tools are useful to identify the link between subjective symptom perceptions and underlying biologically pathways. Fatigue status in HIV patients treated with NRTIs was found to be linked to RNA expression differences related to mitochondrial function. Additional studies are needed to confirm the relevance of our findings in CD14+ cells in other tissues (e. g. skeletal muscle) and to understand the significance of key genes such as SULT2B and ADCY2 in fatigue and HIV disease. The design was a comparison of HIV high fatigue to HIV low fatigue. Low fatigue was determined as 3-7 on the Revised Piper Fatigue Score and High fatigue was a score of 7 or greater. Five HIV ne...


Displaying 20 of 28 results for "ADCY7"