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Displaying 8 of 8 results for "ADAM7"
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  1. Analysis of Meniscal Degeneration and Meniscal Gene Expression ArrayExpress

    ID: E-GEOD-19060

    Description: ssive homolog (ANKH) and fibroblast growth factor 7 (FGF7), were expressed at higher levels compared to normal control meniscal cells. In addition, many genes that were previously implicated in OA were also expressed at higher levels in OA meniscal cells, including ADAM metallopeptidase with thrombospondin type 1 motif, 5 (ADAMTS5). Our findings suggest that OA is a whole joint disease. Meniscal cells may play an active role in the development of OA. Investigation of the gene expression profiles of OA meniscal cells may reveal new therapeutic targets for OA therapy and also may uncover novel disease markers for early diagnosis of OA. Studies were approved by our human subjects Institutional Review Board. Menisci and articular cartilage were collected during joint replacement surgery for OA patients (OA specimens) and lower limb amputation surgery for osteosarcoma patients (normal control specimens), and graded. Meniscal cells were prepared from the meniscal tissues and expanded in monolayer culture. Differential gene expression in OA meniscal cells and normal control meniscal cells was examined using Affymetrix microarray and real time RT-PCR....

  2. Epigenetic silencing of triple negative breast cancer hallmarks by Withaferin A BioProject

    ID: PRJNA381767

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ermethylation of tumor promoting genes including ADAM metallopeptidase domain 8 (ADAM8), urokinase-type plasminogen activator (PLAU), tumor necrosis factor (ligand) superfamily, member 12 (TNFSF12), and genes related to detoxification (glutathione S-transferase mu 1, GSTM1), or mitochondrial metabolism (malic enzyme 3, ME3). Gene expression and pathway enrichment analysis further reveals epigenetic suppression of multiple cancer hallmarks associated with cell cycle regulation, cell death, cancer cell metabolism, cell motility and metastasis. Remarkably, DNA hypermethylation of corresponding CpG sites in PLAU, ADAM8, TNSF12, GSTM1 and ME3 genes correlates with receptor tyrosine-protein kinase erbB-2 amplification (HER2)/estrogen r...
  3. SEQUENCE-DEPENDENT CONFORMATION OF AN A-DNA DOUBLE HELIX: THE CRYSTAL STRUCTURE OF THE OCTAMER D(G-G-T-A-T-A-C-C) PDB

    ID: PDB:1VJ4

    Description: 5'-D(*GP*GP*TP*AP*TP*AP*CP*C)-3'

  4. Analysis of Meniscal Degeneration and Meniscal Gene Expression BioProject

    ID: PRJNA120565

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ssive homolog (ANKH) and fibroblast growth factor 7 (FGF7), were expressed at higher levels compared to normal control meniscal cells. In addition, many genes that were previously implicated in OA were also expressed at higher levels in OA meniscal cells, including ADAM metallopeptidase with thrombospondin type 1 motif, 5 (ADAMTS5). Our findings suggest that OA is a whole joint disease. Meniscal cells may play an active role in the development of OA. Investigation of the gene expression profiles of OA meniscal cells may reveal new therapeutic targets for OA therapy and also may uncover novel disease markers for early diagnosis of OA. Overall design: Studies were approved by our human subjects Institutional Review Board. Menisci and articular cartilage were collected during joint replacement surgery for OA patients (OA specimens) and lower limb amputation surgery for osteosarcoma patients (normal control specimens), and graded. Meniscal cells were prepared from the meniscal tissues and expanded in monolayer culture. Differential gene expression in OA meniscal cells and normal control meniscal cells was examined using Affymetrix microarray and real time RT-PCR....
  5. Mobile measurement of methane and hydrogen sulfide at natural gas production site fence lines in the Texas Barnett Shale Figshare

    ID: doi:10.6084/M9.FIGSHARE.979304.V3

    Release Date: 03-10-2016

    Description:

    dataset.creators: Eapi, Gautam R.
  6. Mobile measurement of methane and hydrogen sulfide at natural gas production site fence lines in the Texas Barnett Shale Figshare

    ID: doi:10.6084/M9.FIGSHARE.979304.V2

    Release Date: 03-10-2016

    Description:

    dataset.creators: Eapi, Gautam R.
  7. Mobile Measurement of Methane and Hydrogen Sulfide at Natural Gas Production Site Fence Lines in the Texas Barnett Shale Figshare

    ID: doi:10.6084/M9.FIGSHARE.979304.V1

    Release Date: 03-10-2016

    Description:

    dataset.creators: Eapi, Gautam R.
  8. Mobile measurement of methane and hydrogen sulfide at natural gas production site fence lines in the Texas Barnett Shale Figshare

    ID: doi:10.6084/M9.FIGSHARE.979304

    Release Date: 03-10-2016

    Description:

    dataset.creators: Eapi, Gautam R.

Displaying 8 of 8 results for "ADAM7"