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Displaying 20 of 62 results for "ABCG2"
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  1. Structure of an ABC transporter: complete structure PDB

    ID: PDB:5NJ3

    Description: ATP-binding cassette sub-family G

  2. Structure of an ABC transporter: part of the structure that could be built de novo PDB

    ID: PDB:5NJG

    Description: ATP-binding cassette sub-family G

  3. shRNA profiling and transcription profiling of mouse H441 cells Over-expressing and knocked down for KLF5 ArrayExpress

    ID: E-GEOD-16555

    Description: plained by KLF5 transcriptional repression of the ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2), an anthracycline transporter. In agreement with this, KLF5 knockdown cells display significantly more Hoechst “side population” and resistance to doxorubicin. In summary, while KLF5 is not an obligate partner in Ras oncogenic signaling, KLF5 control of ABCG2 expression is significant to patient survival. Experiment Overall Design: Total RNA was extracted from H441 cells transduced with KLF5-specific shRNA (KD), KLF5 over expression (OE) and MSCV empty vertor (NT) respectively. The cRNAs was then hybridized to Human Genome U133 Plus 2.0 Arrays (Affymetrix) according to manufacturer’s protocol....

  4. shRNA profiling and transcription profiling of mouse H441 cells Over-expressing and knocked down for KLF5 OmicsDI

    ID: E-GEOD-16555

    Date Released: 06-10-2011

    Description: plained by KLF5 transcriptional repression of the ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2), an anthracycline transporter. In agreement with this, KLF5 knockdown cells display significantly more Hoechst “side population” and resistance to doxorubicin. In summary, while KLF5 is not an obligate partner in Ras oncogenic signaling, KLF5 control of ABCG2 expression is significant to patient survival. Experiment Overall Design: Total RNA was extracted from H441 cells transduced with KLF5-specific shRNA (KD), KLF5 over expression (OE) and MSCV empty vertor (NT) respectively. The cRNAs was then hybridized to Human Genome U133 Plus 2.0 Arrays (Affymetrix) according to manufacturer’s protocol....

  5. Over-expression and knockdown of KLF5 BioProject

    ID: PRJNA116185

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: plained by KLF5 transcriptional repression of the ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2), an anthracycline transporter. In agreement with this, KLF5 knockdown cells display significantly more Hoechst “side population” and resistance to doxorubicin. In summary, while KLF5 is not an obligate partner in Ras oncogenic signaling, KLF5 control of ABCG2 expression is significant to patient survival. Overall design: Total RNA was extracted from H441 cells transduced with KLF5-specific shRNA (KD), KLF5 over expression (OE) and MSCV empty vertor (NT) respectively. The cRNAs was then hybridized to Human Genome U133 Plus 2.0 Arrays (Affymetrix) according to manufacturer’s protocol....
  6. Novel ABCG2 antagonists to reverse topotecan-mediated chemotherapeutic resistance in ovarian carcinoma xenografts. BioProject

    ID: PRJNA338878

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. MOESM3 of Selectivity profiling of BCRP versus P-gp inhibition: from automated collection of polypharmacology data to multi-label learning Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3697444_D1

    Release Date: 02-21-2017

    Description: Additional file 3. The whole dataset (2191 compounds) as used in the binary relevanceâ chains of classifiers script.

  8. MOESM2 of Selectivity profiling of BCRP versus P-gp inhibition: from automated collection of polypharmacology data to multi-label learning Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3697444_D4

    Release Date: 02-21-2017

    Description: Additional file 2. The dense dataset (161 compounds) with the label-powerset transformation of the classes.

  9. Mixed effects of OATP1B1, BCRP and NTCP polymorphisms on the population pharmacokinetics of pravastatin in healthy volunteers Figshare

    ID: doi:10.6084/M9.FIGSHARE.1632778.V1

    Release Date: 03-11-2016

    Description:

  10. Transcription profiling by array of Doxorubicin (DOX)-resistant MCF7 breast cancer cells ArrayExpress

    ID: E-MTAB-1643

    Description: rmore, TFPI1 and Breast Cancer Resistant Protein (BCRP) levels increased early and remained sustained during selection. Finally, consistent with antithrombin-mediated hypoxic metastasis, Hypoxia-Inducible Factor 1 alpha (HIF1alpha) was elevated in drug resistant and TFPI1 overexpressing cells. Thus, increased TFPI1 may create an intratumoral hypoxic environment, potentially leading to drug resistance. MCF7 cells were selected for DOX resistance by first treating the cells with 1 microM DOX for 48 hours. The cells were then exposed to 100 nM DOX for 2 weeks. After this period, the surviving cells were resistant to further DOX treatment....

  11. Electron cryo-microscopy of ABCG2 from two-dimensional crystals PDBe:EMDB

    Types: Image stored as Reals

    Person: Rosenberg MF, Bikadi Z, Hazai E, Starborg T, Kelley L, Chayen NE, Ford RC, Mao Q

    Release Date: 07-15-2015

  12. Cavard Agilent ArrayExpress

    ID: E-MEXP-2821

    Description: hesis (CYP7A1, CYP27A1 and CYP7B1) and transport (ABCG2/BCRP, ABCC2/MRP2, ABCB11/BSEP, OATP8/SLC01B3) of bile acids. However, the composition of bile in these tumors is not significantly modified. The large amount of bilirubin in these tumors follows the increase in biliverdin pigment reflecting the characteristic green color of these tumors and biliary acids content is not profoundly altered. Surprisingly, the main change affects the non-tumoral counterparts of HCC with mutant B-catenin which display an unexpected high content in biliary acids. These observations suggest that increased bile acids level due to an underlying pathology may play a role in the emergence of HCC with mutant B-catenin....

  13. P2B6, CYP1A2, OATP1B1, OCT1, MDR1, MRP2, MRP3 and BCRP in cryopreserved human hepatocytes in sandwich culture... Figshare

    ID: doi:10.6084/M9.FIGSHARE.1604765

    Release Date: 03-11-2016

    Description:

  14. P2B6, CYP1A2, OATP1B1, OCT1, MDR1, MRP2, MRP3 and BCRP in cryopreserved human hepatocytes in sandwich culture... Figshare

    ID: doi:10.6084/M9.FIGSHARE.1604765.V1

    Release Date: 03-11-2016

    Description:

  15. The impact of a drug transporter ABCG2 haplotype in molecular response of chronic myelogenous leukemia patients is modulated by imatinib dose BioProject

    ID: PRJNA226696

    Keywords: Variation

    Access Type: download

  16. Crystal structure of 5D3 Fab PDB

    ID: PDB:5NIV

    Description: Light chain of 5D3 Fab, Heavy chain of 5D3 Fab

    dataset.keywords: ABCG2
  17. Human lung MPC BioProject

    ID: PRJNA368696

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: as previously published in Marriott et al. 2014. ABCG2(pos) lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling. American Journal of Physiology - Cell Physiology.C684-C698. 5 controls and 4 IPF cell lines from independent patients were used. RNA was isolated using a Qiagen kit and chips run by the University of Colorado Gen...
  18. Data from: Serum-free and xenobiotic-free preservation of cultured human limbal epithelial cells Dryad

    DateIssued: 03-09-2015

    Description: r immature cells (ΔNp63α, p63, Bmi-1, C/EBP∂, ABCG2 and K19), differentiated cells (K3 and Cx43), proliferation (PCNA), and apoptosis (Caspase-3). Results: The cell viability of the cultures was 98 ± 1% and remained high after storage. Mean central thickness of non-stored limbal epithelial sheets was 23 ± 3 μm, and no substantial loss of cells was observed after storage. The non-stored epithelial sheets expressed a predominantly immature phenotype with ΔNp63α positivity of more than 3% in 9 of 13 cultures. After storage, the expression of ABCG2 and C/EBP∂ was reduced for the 7 day Quantum 286-storage group; (P = 0.04), and Bmi-1 was reduced after 4 day Quantum 286-storage; (P = 0.02). No other markers varied significantly. The expression of differentiation markers was unrelated to the thickness of the epithelia and amniotic membrane, apart...

  19. Expression data of MCF7/ADR cells treated with MC70, an ABC transporters inhibitor ArrayExpress

    ID: E-GEOD-26250

    Description: . The study was carried out in MCF7/ADR and Caco-2, breast and colon cancer cells, respectively. Cell growth and apoptosis were measured by MTT assay and DNA laddering Elisa kit, respectively. Cell cycle perturbation and cellular targets modulation were analyzed by flow cytometry and western blotting, respectively. MC70 was analyzed for its interaction with ABC transporters, MDR-1, BCRP and MRP-1, and for its anticancer activity. In MCF7/ADR, MC70 slight inhibited cell proliferation and...

  20. Genome-wide DNA methylation in murine ascitic leukemia cells (P388) ArrayExpress

    ID: E-GEOD-48642

    Description: mined for 1) in vitro colony formation potential, 2) in vivo tumorigenicity and aggressiveness, 3) development of drug resistance and Wnt signaling activation 4) global DNA methylation profiles, and 5) expression of CSC markers. Results: SP1049C treatment reduced tumor aggressiveness, in vivo tumor formation frequency and in vitro clonogenic potential of the ascitic cells compared to drug, saline and polymer controls. SP1049C also prevented overexpression of BCRP and activation of Wnt-β-catenin signaling observed with Dox alone. Moreover SP1049C significantly altered the DNA methylation profiles of the cells. Finally, SP1049C decreased CD133+ P388 cells populations, which displayed CSC-like properties and were more tumorigenic compared to CD133- cells. Conclusions: SP1049C therapy effectively suppresses the tumorigenicity and aggressiveness of P388 cells in a mouse model. This may be due to enhanced activity of SP1049C against CSC and/or altered epigenetic regulation restricting appearance of malignant cancer cell phenotype. DNA methylation wa...


Displaying 20 of 62 results for "ABCG2"