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Displaying 20 of 1,320 results for "ABCC8"
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  1. Cryo-EM structure of the pancreatic ATP-sensitive K+ channel SUR1/Kir6.2 in the presence of ATP and glibenclamide PDB

    ID: PDB:5TWV

    Description: ATP-sensitive inward rectifier potassium channel 11, ATP-binding cassette ...

  2. Staphylococcus aureus subsp. aureus strain:SUR1 : Staphylococcus aureus subsp. aureus strain:SUR1 Genome sequencing BioProject

    ID: PRJNA260675

    Keywords: Genome sequencing

    Access Type: download

    organism.strain: SUR1
  3. Rfx6 target genes in the Min6b1 cell line, a pancreatic beta cell model ArrayExpress

    ID: E-GEOD-62844

    Description: ulin secretion pathway including GLucokinase, the Abcc8/SUR1 subunit of KATP channels and voltage-gated Ca2 channels, which are direct targets of Rfx6. Moreover, Rfx6 contributes to the silencing of the vast majority of “disallowed” genes, a group usually specifically repressed in adult beta cells, and thus to the maintenance of beta cell maturity. These findings raise the possibility that changes in Rfx6 expression or activity may contribute to beta cell failure in man. Two ChIP-Seq experiments have been performed : 1) anti-HA ChIP-Seq on 3HA-Rfx6 transfected Min6b1 cells and 2) anti-HA ChIP-Seq on Min6b1 cells...

  4. Next Generation Mendelian Genetics: Hyperinsulinemia BioProject

    ID: PRJNA174120

    Keywords: Phenotype or Genotype

    Access Type: download

  5. Homo sapiens : Next Generation Mendelian Genetics: Hyperinsulinemia BioProject

    ID: PRJNA174119

    Access Type: download

  6. Next Generation Mendelian Genetics: Neonatal Diabetes BioProject

    ID: PRJNA174116

    Keywords: Phenotype or Genotype

    Access Type: download

    dataset.description: 3, GCK, FOXP3, GLIS3, PTF1A, HNF1Beta, KCNJ11 and ABCC8). The two subunits of the ATP-sensitive K channel (ABCC8 and KCNJ11) and the insulin gene (INS), account for almost half of the cases and similar to CHI, the other half, remains genetically unexplained. We became part of this study when we submitted 4 DNA samples for exome sequencing, from patients with NDM of Caucasian... (for more see dbGaP study page.)...
  7. Homo sapiens : Next Generation Mendelian Genetics: Neonatal Diabetes BioProject

    ID: PRJNA174115

    Access Type: download

    dataset.description: 3, GCK, FOXP3, GLIS3, PTF1A, HNF1Beta, KCNJ11 and ABCC8). The two subunits of the ATP-sensitive K channel (ABCC8 and KCNJ11) and the insulin gene (INS), account for almost half of the cases and similar to CHI, the other half, remains genetically unexplained. We became part of this study when we submitted 4 DNA samples for exome sequencing, from patients with NDM of Caucasian... (for more see dbGaP study page.)...
  8. Next Generation Mendelian Genetics: Neonatal Diabetes OmicsDI

    ID: phs000542.v1.p1

    Date Released:

    Description: 3, GCK, FOXP3, GLIS3, PTF1A, HNF1Beta, KCNJ11 and ABCC8). The two subunits of the ATP-sensitive K channel (ABCC8 and KCNJ11) and the insulin gene (INS), account for almost half of the cases and similar to CHI, the other half, remains genetically unexplained.

    We became part of this study when we submitted 4 DNA samples for exome sequencing, from patients with NDM of Caucasian ancestry, which had no mutations identified in ABCC8 or KCNJ1, with the goal to identify new mutations in known genes or new mutations or genetic variants in new genes.

    ...

  9. Next Generation Mendelian Genetics: Congenital Hyperinsulinism OmicsDI

    ID: phs000539.v1.p1

    Date Released:

    Description: emia in the newborn and it is due to mutations in 8 different genes (ABCC8, KCNJ11, GLUD1, GCK, HADH, SLC16A1, HNF4A and UCP2). It is a heterogeneous disease with variable onset (birth to adulthood) and a persistent, intermittent, or transient course with possible later conversion to non-autoimmune diabetes. Although mutations in the two subunits of the KATP channel (<...

  10. Rfx6 target genes in the Min6b1 cell line, a pancreatic beta cell model OmicsDI

    ID: E-GEOD-62844

    Date Released: 01-02-2015

    Description: ulin secretion pathway including GLucokinase, the Abcc8/SUR1 subunit of KATP channels and voltage-gated Ca2 channels, which are direct targets of Rfx6. Moreover, Rfx6 contributes to the silencing of the vast majority of “disallowed” genes, a group usually specifically repressed in adult beta cells, and thus to the maintenance of beta cell maturity. These findings raise the possibility that changes in Rfx6 expression or activity may contribute to beta cell failure in man. Two ChIP-Seq experiments have been performed : 1) anti-HA ChIP-Seq on 3HA-Rfx6 transfected Min6b1 cells and 2) anti-HA ChIP-Seq on Min6b1 cells...

  11. Rfx6 target genes in the Min6b1 cell line, a pancreatic beta cell model BioProject

    ID: PRJNA265822

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ulin secretion pathway including GLucokinase, the Abcc8/SUR1 subunit of KATP channels and voltage-gated Ca2 channels, which are direct targets of Rfx6. Moreover, Rfx6 contributes to the silencing of the vast majority of “disallowed” genes, a group usually specifically repressed in adult beta cells, and thus to the maintenance of beta cell maturity. These findings raise the possibility that changes in Rfx6 expression or activity may contribute to beta cell failure in man. Overall design: Two ChIP-Seq experiments have been performed : 1) anti-HA ChIP-Seq on 3HA-Rfx6 transfected Min6b1 cells and 2) anti-HA ChIP-Seq on Min6b1 cells...
  12. HMEC gene profile after stimulation with MRP8/MRP14 BioProject

    ID: PRJNA95987

    Keywords: Transcriptome or Gene expression

    Access Type: download

  13. Genome-wide expression analysis demonstrates a dominant role of TLR4 for activation of human phagocytes by the alarmin MRP8 BioProject

    ID: PRJNA244307

    Keywords: Transcriptome or Gene expression

    Access Type: download

  14. onocyte stimulated with various stimuli (control, MRP8, LPS, TNF, IL1) to study signalling pathways in phagocytic activation... OmicsDI

    ID: E-GEOD-56681

    Date Released: 05-01-2015

    Description: The alarmins myeloid-related protein (MRP) 8 and MRP14 are the dominant cytoplasmic proteins in phagocytes. After release by activated phagocytes extr...

  15. PRJEB1956 BioProject

    Keywords: Exome

    Access Type: download

    dataset.description: β-cells; recessive inactivating mutations in the ABCC8 and KCNJ11 genes represent the most common events. Despite the advances in understanding the molecular pathogenesis of CHI, specific genetic determinants in about 50 % of the CHI patients remain unknown, suggesting additional locus heterogeneity. In order to search for novel loci contributing to the pathogenesis of CHI, we combined a family
  16. CHI : Exome sequencing in congenital hyperinsulinism BioProject

    ID: PRJEB1932

    Keywords: Exome

    Access Type: download

    dataset.description: β-cells; recessive inactivating mutations in the ABCC8 and KCNJ11 genes represent the most common events. Despite the advances in understanding the molecular pathogenesis of CHI, specific genetic determinants in about 50 % of the CHI patients remain unknown, suggesting additional locus heterogeneity. In order to search for novel loci contributing to the pathogenesis of CHI, we combined a family
  17. suppl Fig 1-6 Dryad

    DateIssued: 01-13-2012

    Description: MtDNA based phylogenetic reonstruction for each genus hypothesized from Bayesian analysis. Supports are indicated as follows: Bayesian analysis poster...

  18. A/H1N1 HI data Dryad

    DateIssued: 02-05-2014

    Description: ted text file giving hemagglutination inhibition (HI) titers for seasonal A/H1N1 influenza viruses and ferret antisera isolated between 1977 and 2009. The virus strain used in the

  19. Transcription profiling of human HMEC after stimulation with MRP8/MRP14 ArrayExpress

    ID: E-GEOD-5474

    Description: GEnerating the the gene expression profil of MRP8/MRP14-stimulated HMEC monolayer. Experiment Overall Design: 4 independent experiments Experiment Overall Design: HMEC-1 monola...

  20. B/Victoria HI data Dryad

    DateIssued: 02-05-2014

    Description: ted text file giving hemagglutination inhibition (HI) titers for seasonal B/Victoria influenza viruses and ferret antisera isolated between 1986 and 2011. The virus strain used in the


Displaying 20 of 1,320 results for "ABCC8"