ABCA1 | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 20 of 77 results for "ABCA1"
i
  1. Gene expression series from murine liver samples comparing ABCA1 over-expression in LDL receptor -/- genetic background BioProject

    ID: PRJNA96137

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. ription profiling of livers from mice overexpress ABCA1 in LDL receptor -/- genetic background to characterize the effects of ABCA1 overexpression... ArrayExpress

    ID: E-GEOD-5496

    Description: Changes in the transcript profile due to ABCA1 expression in murine liver samples was evaluated in LDL receptor -/- genetic backgrounds. Experiment Overall Design: Case (

  3. ription profiling of livers from mice overexpress ABCA1 in LDL receptor -/- genetic background to characterize the effects of ABCA1 overexpression.... OmicsDI

    ID: E-GEOD-5496

    Date Released: 03-27-2012

    Description: Changes in the transcript profile due to ABCA1 expression in murine liver samples was evaluated in LDL receptor -/- genetic backgrounds. Experiment Overall Design: Case (

  4. Cryo-EM structure of human ABCA1 PDB

    ID: PDB:5XJY

    Description: ATP-binding cassette sub-family A member 1

  5. Dysregulation of cholesterol homeostasis in human prostate cancer through loss of ABCA1 BioProject

    ID: PRJNA152789

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. Transcription profiling of mouse embryonic stem (ES) cells to study the effect of Abca1 +/- mutations in ES cells ArrayExpress

    ID: E-GEOD-614

    Description: effect of +/- mutations in ES cells

  7. Dysregulation of cholesterol homeostasis in human prostate cancer through loss of ABCA1 ArrayExpress

    ID: E-GEOD-35401

    Description: We conducted gene expression profilling of common prostate cell lines for comparison with genome-wide DNA methylation profiles for the same cell lines...

  8. Expression data from hepatocytes of Tangier disease and control subjects BioProject

    ID: PRJNA377252

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: The transcriptional effects of ABCA1 deficiency in human primary hepatocytes is not clear. We generated iPSC-derived hepatocytes from a Tangier disease patient an...
  9. Transcription profiling of mouse embryonic stem (ES) cells to study the effect of Abca1 +/- mutations in ES cells. OmicsDI

    ID: E-GEOD-614

    Date Released: 03-27-2012

    Description: effect of +/- mutations in ES cells

  10. Effect of LXR activation on LPS-induced inflammatory response in immortalized bone marrow macrophages from LXRa/b knockout mice stably expressing LXR ... BioProject

    ID: PRJNA288720

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: eover, we identify the putative lipid transporter ABCA1 as a critical mediator of LXR’s anti-inflammatory effects. Ligand activation of LXR inhibits signaling from TLR4 to its downstream NF-κB and MAPK effectors through ABCA1-dependent changes in membrane lipid composition and organization that disrupt the recruitment of MyD88 and TRAF6. These data suggest that a common mechanism–direct transcriptional activation–underlies the dual biological functions of LXRs in metabolism and inflammation. Overall design: Cells were placed in DMEM containing 0.5% FBS, 5 μM simvastatin, 100 μM mevalonic acid and 1μM GW3965 or DMSO overnight. Cells were then stimulated with 10ng/ml LPS or vehicle for 4 hours. Each sample contains pooled ...
  11. freshwater metagenome : Ammonia oxizidizing archaea and bacteria Metagenome BioProject

    ID: PRJNA196465

    Keywords: metagenome

    Access Type: download

  12. PRJNA347616 BioProject

    Keywords: raw sequence reads

    Access Type: download

  13. Dysregulation of cholesterol homeostasis in human prostate cancer through loss of ABCA1 OmicsDI

    ID: E-GEOD-35401

    Date Released: 06-02-2014

    Description: We conducted gene expression profilling of common prostate cell lines for comparison with genome-wide DNA methylation profiles for the same cell lines...

  14. MicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells ArrayExpress

    ID: E-GEOD-41737

    Description: ptional factor, RXRα, and the lipid transporter, ABCA1 Carrying out a Target Scan (Release 5.2) of miR-27a predicted 921 candidate target genes, and functional gene ontology enrichment analysis of these genes by MetaCore (Thomson Reuters, NY) showed that miR-27a could target the signaling pathways of cytoskeleton remodeling and lipid metabolism . To examine whether these signaling pathways were regulated by miR-27a, gene expression profiling was carried out in Huh-7.5 cells in which miR-27a was over- or under-expressed. Transfection of cells with pre-miR-27a and pre-miR-control, or anti-miR-27a and anti-miR-control enabled down- and up-regulated genes to be determined, respectively. Huh-7.5 cells with miR-27a over- or under-expressed...

  15. Effect of LXR activation on LPS-induced inflammatory response in primary bone marrow macrophages from ABCA1fl/fl LysM Cre and control wildtype mice BioProject

    ID: PRJNA288719

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: eover, we identify the putative lipid transporter ABCA1 as a critical mediator of LXR’s anti-inflammatory effects. Ligand activation of LXR inhibits signaling from TLR4 to its downstream NF-κB and MAPK effectors through ABCA1-dependent changes in membrane lipid composition and organization that disrupt the recruitment of MyD88 and TRAF6. These data suggest that a common mechanism–direct transcriptional activation–underlies the dual biological functions of LXRs in metabolism and inflammation. Overall design: Cells were placed in DMEM containing 0.5% FBS, 5 μM simvastatin, 100 μM mevalonic acid and 1μM GW3965 or DMSO overnight. Cells were then stimulated with 10ng/ml LPS or vehicle for 4 hours.Each sample contain contains ...
  16. effect of +/- mutations in ES cells GEMMA

    ID: 107

    Keywords: functional genomics

    Description: s affecting cholesterol transport and metabolism. Abca1 +/- and Cdk4 +/- ES lines compared with controls.....

  17. American Crocodile Juvenile Growth and Survival Dryad

    DateIssued: 04-21-2011

    Description: Design and develop a monitoring program for growth and survival of crocodiles in areas that will be affected by CERP projects and conduct surveys for ...

  18. NHLBI GO-ESP: Family Studies (Mendelian Lipid Disorders) dbGaP

    ID: phs000587.v1.p1

    Description: below the age- and sex- specific 10th percentile. ABCA1, LCAT, and APOA1 are known to cause familial hypoalphalipoproteinemia. We hypothesize that: (1) additional novel genes responsible for Mendelian forms of low HDL-C exist; and (2) the causal gene and mutation(s) in each family may be discovered with exome analysis of just a few affected individuals in each pedigree....

    Study Types: Case Set

  19. X-ray structure of benzisoxazole synthetic agonist bound to the LXR-alpha PDB

    ID: PDB:3IPS

    Description: Oxysterols receptor LXR-alpha, Nuclear receptor coactivator 1 (E.C.2.3.1.48)

    dataset.keywords: ABCA1
  20. Expression analysis of African Green Monkeys after treatment with a miR-33a/b-targeting LNA-antimiR ArrayExpress

    ID: E-GEOD-50116

    Description: sults in de-repression of miR-33 targets, such as ABCA1, increases circulating high-density lipoprotein-cholesterol (HDL-C), and is well tolerated over 108 days of treatment. These findings demonstrate the efficacy and safety of an 8-mer LNA-antimiR against a miRNA family in a non-human primate metabolic disease model, suggesting that this could be a feasible approach for therapeutic targeting of miRNA families sharing the same seed sequence in human diseases. Expression analysis study in obese Non Human Primates (African Green Monkeys). Five animals treated with antimiR-33a/b were compared to five animals treated with vehicle....


Displaying 20 of 77 results for "ABCA1"