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Dataset Title Dataset ID Primary Publications Keywords
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with thymine PDB:4QSU Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
S
ATPase family AAA domain-containing protein 2
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with N-Methyl-2-pyrrolidone (NMP) PDB:4QSS Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
S
ATPase family AAA domain-containing protein 2
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with 3'-deoxy thymidine PDB:4QSX Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
S
ATPase family AAA domain-containing protein 2
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with 5-methyl uridine PDB:4QSW Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
S
ATPase family AAA domain-containing protein 2
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) with bound DMSO PDB:4QSQ Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
S
ATPase family AAA domain-containing protein 2
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with 1-methylquinolin 2-one PDB:4QST Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
S
ATPase family AAA domain-containing protein 2
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) with bound MPD PDB:4QSR Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
S
ATPase family AAA domain-containing protein 2
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with acetyl-lysine PDB:4QSP Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
S
ATPase family AAA domain-containing protein 2
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with thymidine PDB:4QSV Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
S
ATPase family AAA domain-containing protein 2
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) complexed with Histone H4-K(ac)12 PDB:4QUT Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells.
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ATPase family AAA domain-containing protein 2
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) complexed with Histone H4-K(ac)5 PDB:4QUU Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells.
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ATPase family AAA domain-containing protein 2
Crystal structure of the bromodomain of the human ATAD2 PDB:3DAI Histone recognition and large-scale structural analysis of the human bromodomain family.
H
ATPase family AAA domain containing 2 AAA+ nuclear coregulator cancer-associated PRO2000 protein two...
Fragment-Based Screening of the Bromodomain of ATAD2 PDB:4TZ2 Fragment-Based Screening of the Bromodomain of ATAD2.
F
ATAD2
Crystal structure of human ATAD2 bromodomain in complex with 8-(((3R,4R,5S)-3-((4,4-difluorocyclohexyl)methoxy)-5-methoxypiperidin-4-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one PDB:5LJ0 A Chemical Probe for the ATAD2 Bromodomain.
A
ATAD2 ATPase family AAA domain-containing protein 2
Fragment-Based Screening of the Bromodomain of ATAD2 PDB:4TYL Fragment-Based Screening of the Bromodomain of ATAD2.
F
Hydrolase/Hydrolase inhibitor
Bromodomain
Hydrolase-Hydrolase inhibitor complex
Structure of human ATAD2 bromodomain bound to fragment inhibitor PDB:4TZ8 Fragment-Based Screening of the Bromodomain of ATAD2.
F
ATAD2
Crystal structure of human ATAD2 bromodomain in complex with 8-(3R,4R) -3-(cyclohexylmethoxy)piperidin-4-yl-amino-3-methyl-1,2-dihydro-1,7- naphthyridin-2-one PDB:5A81 Structure-Based Optimization of Naphthyridones Into Potent Atad2 Bromodomain Inhibitors.
S
ATAD2 ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2
Crystal structure of human ATAD2 bromodomain in complex with 8-2-(dimethylamino)ethylamino-3-methyl-1,2-dihydroquinolin-2-one PDB:5A5P Fragment-Based Discovery of Low-Micromolar Atad2 Bromodomain Inhibitors.
F
ATAD2 ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2
Crystal structure of human ATAD2 bromodomain in complex with 3-methyl- 8-piperidin-4-ylamino-1,2-dihydro-1,7-naphthyridin-2-one hydrochloride PDB:5A5Q Fragment-Based Discovery of Low-Micromolar Atad2 Bromodomain Inhibitors.
F
ATAD2 ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2
Crystal structure of human ATAD2 bromodomain in complex with 5-5- methoxypyridin-3-yl-3-methyl-8-piperidin-4-ylamino-1,2-dihydro-1,7- naphthyridin-2-one PDB:5A5R Fragment-Based Discovery of Low-Micromolar Atad2 Bromodomain Inhibitors.
F
ATAD2 ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2
Crystal structure of human ATAD2 bromodomain in complex with 4-(3R,4R) -4-(3-methyl-2-oxo-1,2-dihydro-1,7-naphthyridin-8-yl)aminopiperidin-3- yloxymethyl)-1-thiane-1,1-dione PDB:5A82 Structure-Based Optimization of Naphthyridones Into Potent Atad2 Bromodomain Inhibitors.
S
ATAD2 ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2
Crystal structure of human ATAD2 bromodomain in complex with 4-((3R, 4R)-4-3-methyl-5-(5-methylpyridin-3-yl)-2-oxo-1,2-dihydroquinolin-8- yl-aminopiperidin-3-yloxymethyl)-1-thiane-1,1-dione PDB:5A83 Structure-Based Optimization of Naphthyridones Into Potent Atad2 Bromodomain Inhibitors.
S
ATAD2 ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2
Crystal structure of human ATAD2 bromodomain in complex with (2S)-2,6- diacetamido-N-methylhexanamide PDB:5A5N Fragment-Based Discovery of Low-Micromolar Atad2 Bromodomain Inhibitors.
F
ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2
Crystal structure of human ATAD2 bromodomain in complex with 3-methyl- 1,2-dihydroquinolin-2-one PDB:5A5O Fragment-Based Discovery of Low-Micromolar Atad2 Bromodomain Inhibitors.
F
ATAD2
Crystal structure of the bromodomain of human ATAD2 in complex with Compound A14 PDB:5F3A Crystal structure of the bromodomain of human ATAD2 in complex with Compound A14
C
TRANSFERASE
HYDROLASE INHIBITOR Complex
TRANSFERASE
Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49 PDB:5EPB Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49
C
TRANSFERASE
HYDROLASE INHIBITOR Complex
TRANSFERASE
Crystal structure of the bromodomain of human ATAD2 in complex with Compound A12 PDB:5F36 To be pubulished
TRANSFERASE
HYDROLASE INHIBITOR Complex
TRANSFERASE
Crystal structure of ATAD2A bromodomain complexed with methyl 3-amino-5-(3,5-dimethyl-1,2-oxazol-4-yl)benzoate PDB:4TTE Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
O
ATAD2 bromodomain inhibitor complex
Crystal structure of ATAD2A bromodomain complexed with H3(1-21)K14Ac peptide PDB:4TT4 Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
O
GENE REGULATION
bromodomain-acetylated histone complex
GENE REGULATION
Crystal structure of ATAD2A bromodomain complexed with H4(1-20)K5Ac peptide PDB:4TT2 Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
O
GENE REGULATION
bromodomain-acetylated histone complex
GENE REGULATION
Crystal Structure of the Bromodomain of Human AAA domain containing 2B (ATAD2B) PDB:3LXJ Histone recognition and large-scale structural analysis of the human bromodomain family.
H
ATPase family AAA domain containing 2B
Crystal structure of ATAD2A bromodomain double mutant N1063A-Y1064A in apo form PDB:4TT6 Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
O
GENE REGULATION
acetyllysine reader deficient bromodomain
GENE REGULATION
Crystal structure of apo ATAD2A bromodomain with N1064 alternate conformation PDB:4TU6 Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
O
GENE REGULATION
bromodomain- conserved asparagine conformations
GENE REGULATION
Crystal structure of ATAD2A bromodomain complexed with 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(phenylsulfonyl)amino]benzoicacid PDB:4TU4 Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
O
GENE REGULATION
ATAD2A - bromodomain- inhibitor complex
GENE REGULATION
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 8-(((3R,4R,5S)-3-((4,4-difluorocyclohexyl)methoxy)-5-methoxypiperidin-4-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one PDB:5LJ1 A Chemical Probe for the ATAD2 Bromodomain.
A
BROMODOMAIN CONTAINING PROTEIN 4
NN-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 5-5-methoxypyridin-3-yl-3- methyl-8-piperidin-4-ylamino-1,2-dihydro-1,7-naphthyridin-2-one PDB:5A5S Fragment-Based Discovery of Low-Micromolar Atad2 Bromodomain Inhibitors.
F
BROMODOMAIN CONTAINING PROTEIN 4
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 8-(3R,4R)-3-(cyclohexylmethoxy)piperidin-4-ylamino-3-methyl-1,2-dihydro-1,7- naphthyridin-2-one PDB:5A85 Structure-Based Optimization of Naphthyridones Into Potent Atad2 Bromodomain Inhibitors.
S
BROMODOMAIN CONTAINING PROTEIN 4
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 5-(5-aminopyridin-3-yl)-8-(((3R,4R)-3-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)piperidin-4-yl)amino)-3-methyl-1,7-naphthyridin-2(1H)-one PDB:5LJ2 A Chemical Probe for the ATAD2 Bromodomain.
A
BROMODOMAIN CONTAINING PROTEIN 4