Toll- like receptor 7 is a primary sensor of malaria infection
Microarray profiling of amplified total splenic RNA isolated from TLR9-, TLR7-, UNC93b1- or MYD88- d...
Dysregulated TLR7 signaling drives anemia via development of hemophagocytic macrophages
The debilitating autoimmune disease Systemic Lupus Erythematosus (SLE) is closely associated with To...
Sustained Efficacy and Seroconversion with the Toll- Like Receptor 7 Agonist GS-9620 in the Woodchuck Model of Chronic Hepatitis B
Background & Aims: New therapies for chronic hepatitis B (CHB) are urgently needed since current tr...
Suppression of molecular inflammatory pathways by Toll- like Receptor 7, 8, and 9 antagonists in a model of IL-23-induced skin inflammation
Psoriasis is a complex inflammatory disease resulting from the activation of T helper (Th) 1 and Th1...
Bruton's Tyrosine Kinase Regulates TLR9 but not TLR7 Signaling in Human pDCs
Plasmacytoid dendritic cells (pDCs) can be activated by the endosomal TLRs, and contribute to the pa...
Transcription profiling of mouse embryonic fibroblasts from wild type and IRAK-4 kinase dead animals stimulated with IL-1b for different durations to identify IRAK-4 kinase-dependent IL-1b response genes
IRAK-4 is an essential component of the signal transduction complex downstream of the IL-1- and Toll...
Cell intrinsic expression of TLR9 in autoreactive B cells constrains BCR/ TLR7-dependent responses
Endosomal Toll-like receptors (TLRs) play an important role in the etiology of systemic autoimmune d...
Treatment of human monocytes with TLR7 or TLR8 agonists
Goal was to detect differences in response to TLR7 versus TLR8 agonists in human monocytes from heal...
Gene profiling in the colon after depletion and activation of TLR3 and TLR7 signals
TLR3 and TLR7 are critical recognition receptor which reacts with viruses. TLR3 and TLR7 contribute ...
Differential gene expression in wild-type versus Yaa mutant mouse spleen cells
T cells from many patients with systemic lupus erythematosus are hypoproliferative in response to TC...
Transcription profiling of mouse model of asthma reveals the effects of resiquimod treatment on the asthma transcriptome
Resiquimod is a nucleoside analog belonging to the imidazoquinoline family of compounds which is kno...
TLR3, TLR7, and TLR9 stimulation in murine dorsal root ganglion neurons
TLR3, TLR7, and TLR9 stimulation induces many mouse inflammatory and autoimmune cytokines or immune ...
Transcription profling by array of mouse dendritic cells treated with bacterial RNA packaged in DOTAP or TLR7 agonist R848
Murine dendritic cells were derived from bone-marrow of 4 mice using GM-CSF. The DC were treated wit...
p53 amplifies Toll- like receptor 5 response in MCF- 7 cells
Using gene expression profiling we characterize the global effect of p53 on the TLR5-mediated transc...
TLR7 gene duplication accelerates autoimmunity and promotes nucleolar-specific B cells
Systemic autoimmune diseases such as lupus and scleroderma are characterized by the loss of toleranc...
Stimulation of isolated plasmacytoid dendritic cells (pDCs) with TLR9 agonist CpG C (CpG) and TLR7 agonist imiquimod (IMQ)
The purpose of this experiment was to assess the genes upregulated when pDCs were stimulated with TL...
Oncogenic MyD88 Mutants Require Toll- like Receptors
In the activated B-cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL), the most freque...
DC populations incubated with rAd5, rAd28, rAd35, TLR7/8-ligand, or unexposed
Recombinant adenovirus vectors (rAds) are being investigated as vaccine delivery vehicles in pre-cli...
Differences in the transcriptomic response of human adult and neonatal dendritic cell subsets to TLR7/8 stimulation
Previous studies have shown that purified dendritic cells (DCs) have cell-intrinsic, age-dependent d...
CD103+ Conventional Dendritic Cells are Critical for TLR-dependent Host Defense against an Endemic Fungal Pathogen
Innate immune cells shape the host response to microbial pathogens. Here we studied the role of TLR7...