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Displaying 13 of 13 results for "PRKN"
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Dataset Title Dataset ID Primary Publications Keywords
S65DParkin and pUB complex PDB:5N38 Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
LIGASE
S65DParkin pUB complex
splicing
ligase
WT-Parkin and pUB complex PDB:5N2W Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
LIGASE
Complex structure of Parkin and pUB
Transferase
ligase
Parkin (UblR0RBR) PDB:5C1Z Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
LIGASE
ligase
Structure of Parkin E3 ligase PDB:4I1H Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases.
LIGASE
RBR E3 ubiquitin ligase
LIGASE
Solution NMR structure of the parkin Ubl domain in complex with the endophilin-A1 SH3 domain PDB:2KNB SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination.
PROTEIN BINDING
Ubl
SH3
parkin
endophilin
Cell junction
Cell membrane
Cell projection
Endoplasmic reticulum
Ligase
Membrane
Metal-binding
Nucleus
Postsynaptic cell membrane
S-nitrosylation
Synapse
Ubl conjugation pathway
Zinc-finger
Endocytosis
Lipid-binding
Phosphoprotein
SH3 domain
PROTEIN BINDING
IBR domain of Human Parkin PDB:2JMO Structure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's disease.
LIGASE
Parkin
IBR
E3 ligase
zinc binding domain
RBR
LIGASE
Parkin (S65DUblR0RBR) PDB:5C23 Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
LIGASE
E3 ligase2
ligase
Solution structure of Serine 65 phosphorylated UBL domain from parkin PDB:5TR5 Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation.
LIGASE
phosphorylation
PINK1
Parkinson's disease
LIGASE
Structure of Parkin-S223P E3 ligase PDB:4I1F Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases.
LIGASE
RBR E3 ubiquitin ligase
LIGASE
Crystal Structure of Parkin E3 ubiquitin ligase (linker deletion; delta 86-130) PDB:4ZYN A Ubl/ubiquitin switch in the activation of Parkin.
LIGASE
RING domains
Ubiquitin-like domain
RBR
LIGASE
Crystal Structure of Parkin PDB:4K95 Structure of parkin reveals mechanisms for ubiquitin ligase activation.
LIGASE
Ubiquitin-like domain
RING domains
zinc fingers
RBR ubiquitin ligase
zinc finger
UbcH7
ubiquitin
mitochondria
LIGASE
Crystal Structure of Parkin C-terminal RING domains PDB:4K7D Structure of parkin reveals mechanisms for ubiquitin ligase activation.
LIGASE
RING domains
zinc fingers
RBR ubiquitin ligase
E3 ubiquitin protein ligase
Ubiquitin
UbcH7
LIGASE
Structure of human Parkin G319A PDB:5C9V Mechanism of phospho-ubiquitin-induced PARKIN activation.
SIGNALING PROTEIN
Parkin
ubiquitin
E3 ligase
RBR
Parkinson's disease
mitophagy
cell signalling
signaling protein