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Displaying 20 of 52 results for "PCSK1"
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Dataset Title Dataset ID Primary Publications Keywords
PC1/3 DCSG sorting domain in CHAPS PDB:2KE3 Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease
F
prohormone convertase
Solution Structure of the Mouse Prohormone Convertase 1 Pro-Domain PDB:1KN6 Solution structure of the pro-hormone convertase 1 pro-domain from Mus musculus.
S
HYDROLASE
BETA-ALPHA-BETA-BETA-ALPHA-BETA
HYDROLASE
The Crystal Structure of Proprotein convertase subtilisin kexin type 9 (PCSK9) PDB:2PMW The Crystal Structure of PCSK9: A Regulator of Plasma LDL-Cholesterol.
subtilisin
WT PCSK9-DELTAC BOUND TO EGF-A H306Y MUTANT OF LDLR PDB:2W2N Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
S
PROPROTEIN CONVERTASE
PCSK9-DELTAC D374A MUTANT BOUND TO WT EGF-A OF LDLR PDB:2W2P Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
S
PROPROTEIN CONVERTASE
PCSK9 J16 Fab complex PDB:3SQO Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates.
<
HYDROLASE/Immune system
cholesterol regulation
LDLR
HYDROLASE-Immune system complex
THE CRYSTAL STRUCTURE OF PCSK9 IN COMPLEX WITH 1D05 FAB PDB:2XTJ A Pcsk9-Binding Antibody that Structurally Mimics the Egf(A) Domain of Ldl-Receptor Reduces Ldl Cholesterol in Vivo.
HYDROLASE/ANTIBODY
HYDROLASE-ANTIBODY COMPLEX
SERINE PROTEASE
LDL-C
LDLR
EGF-A
HYPERCHOLESTEROLEMIA
PCSK9-DELTAC D374H MUTANT BOUND TO WT EGF-A OF LDLR PDB:2W2Q Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
S
PROPROTEIN CONVERTASE
PCSK9-DELTAC D374Y MUTANT BOUND TO WT EGF-A OF LDLR PDB:2W2O Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
S
PROPROTEIN CONVERTASE
PC1/3 DCSG sorting domain structure in DPC PDB:2KDT Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease.
F
prohorme convertase
Crystal structure of PCSK9 in complex with Fab from LDLR competitive antibody PDB:3H42 From the Cover: A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates.
F
HYDROLASE/IMMUNE SYSTEM
Hydrolase
Protein Fab Complex
Autocatalytic cleavage
Cholesterol metabolism
Disease mutation
Disulfide bond
Glycoprotein
Lipid metabolism
Phosphoprotein
Protease
Secreted
Serine protease
Steroid metabolism
Zymogen
HYDROLASE-IMMUNE SYSTEM COMPLEX
The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation PDB:3P5C Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
Convertase
The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain PDB:2QTW The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain.
pro-protein convertase
The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation PDB:3P5B Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
convertase
WT PCSK9-DELTAC BOUND TO WT EGF-A OF LDLR PDB:2W2M Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
S
HYDROLASE/RECEPTOR
HYDROLASE-RECEPTOR COMPLEX
CARDIOVASCULAR DISEASE
FAMILIAL HYPERCHOLESTEROLEMIA
LIPID METABOLISM
SERINE PROTEASE
LIPID TRANSPORT
STEROID METABOLISM
Crystal Structure of PCSK9 PDB:2P4E Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia.
subtilisin
Crystal structure of PCSK9(53-451) with Adnectin PDB:4OV6 Pharmacologic Profile of the Adnectin BMS-962476, a Small Protein Biologic Alternative to PCSK9 Antibodies for Low-Density Lipoprotein Lowering.
HYDROLASE/PROTEIN BINDING
PCSK9
Adnectin
LDL-cholesterol
HYDROLASE-PROTEIN BINDING complex
PCSK9 in complex with LDLR peptide PDB:4NE9 Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro.
HYDROLASE
PCSK9
LDL RECEPTOR
AUTOCATALYTIC CLEAVAGE
CHOLESTEROL METABOLISM
HYDROLASE
An Antibody Against the C-terminal Domain of PCSK9 lowers LDL Cholesterol Levels in vivo PDB:4K8R An Antibody against the C-Terminal Domain of PCSK9 Lowers LDL Cholesterol Levels In Vivo.
IMMUNE SYSTEM
Immunoglobulin
IMMUNE SYSTEM
PCSK9:EGFA (pH 7.4) PDB:3GCX Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells.
PROTEIN BINDING
PCSK9
LDL receptor
Autocatalytic cleavage
Cholesterol metabolism
Disease mutation
Glycoprotein
Hydrolase
Lipid metabolism
Phosphoprotein
Protease
Secreted
Serine protease
Steroid metabolism
Zymogen
Coated pit
EGF-like domain
Endocytosis
Host-virus interaction
LDL
Lipid transport
Membrane
Receptor
Transmembrane
Transport
PROTEIN BINDING