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Dataset Title Dataset ID Primary Publications Keywords
NEUROTROPHIN 4 (HOMODIMER) PDB:1B98 The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site.
T
HORMONE/GROWTH FACTOR TARGET-DERIVED SURVIVAL FACTOR NEUROTROPHIN 4 NEUROTROPHIN 5 HORMONE-GROWTH FA...
BRAIN DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-4 PDB:1B8M The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site.
T
GROWTH FACTOR/NEUROTROPHIN-4 COMPLEX (GROWTH FACTOR-GROWTH FACTOR) NEUROTROPHIN GROWTH FACTOR-NEUROT...
CRYSTAL STRUCTURE OF TRKB-D5 BOUND TO NEUROTROPHIN-4/5 PDB:1HCF Specificity in Trk-Receptor:Neurotrophin Interaction: The Crystal Structure of Trkb-D5 in Complex with Neurotrophin-4/5
S
COMPLEX(TRANSFERASE-GROWTH FACTOR) NEUROTROPHIN-4/5
Neurotrophin-3 from Human PDB:1B8K The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site.
T
HORMONE/GROWTH FACTOR COMPLEX (GROWTH FACTOR-GROWTH FACTOR) NEUROTROPHIN HORMONE-GROWTH FACTOR COMPL...
DEATH DOMAIN OF P75 LOW AFFINITY NEUROTROPHIN RECEPTOR, RESIDUES 334-418, NMR, 20 STRUCTURES PDB:1NGR NMR structure of the death domain of the p75 neurotrophin receptor.
N
NEUROTROPHIN RECEPTOR
The structure of TrkA kinase bound to the inhibitor N~4~-(4-morpholin-4-ylphenyl)-N~6~-(pyridin-3-ylmethyl)pyrido[3,2-d]pyrimidine-4,6-diamine PDB:4PMT Maximizing diversity from a kinase screen: identification of novel and selective pan-Trk inhibitors for chronic pain.
Transferase/Transferase inhibitor
kinase
Transferase-Transferase inhibitor complex
Crystal structure of carbon-sulfur lyase involved in aluminum resistance (YP_878183.1) from CLOSTRIDIUM NOVYI NT at 2.90 A resolution PDB:3GWP Crystal structure of carbon-sulfur lyase involved in aluminum resistance (YP_878183.1) from CLOSTRIDIUM NOVYI NT at 2.90 A resolution
C
LYASE
YP_878183.1
carbon-sulfur lyase involved in aluminum resistance
Structural Genomics
Joint Center for Structural Genomics
JCSG
Protein Structure Initiative
PSI-2
LYASE
TrkA JM-kinase with 2-fluoro-{N}-[2-(4-fluorophenyl)-6-methyl-3-pyridyl]-4-(trifluoromethyl)benzamide PDB:5KMK Structural characterization of nonactive site, TrkA-selective kinase inhibitors.
TRANSFERASE/TRANSFERASE INHIBITOR
kinase
juxtamembrane
inhibitor
TRANSFERASE-TRANSFERASE INHIBITOR complex
TrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-(2-pyridyl)urea PDB:5KMO Structural characterization of nonactive site, TrkA-selective kinase inhibitors.
TRANSFERASE/TRANSFERASE INHIBITOR
kinase
juxtamembrane
inhibitor
TRANSFERASE-TRANSFERASE INHIBITOR complex
TrkA JM-kinase with 1-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea PDB:5KML Structural characterization of nonactive site, TrkA-selective kinase inhibitors.
TRANSFERASE/TRANSFERASE INHIBITOR
kinase
juxtamembrane
inhibitor
TRANSFERASE-TRANSFERASE INHIBITOR complex
The structure of TrkA kinase bound to the inhibitor 4-naphthalen-1-yl-1-[(5-phenyl-1,2,4-oxadiazol-3-yl)methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid PDB:4PMS Maximizing diversity from a kinase screen: identification of novel and selective pan-Trk inhibitors for chronic pain.
Transferase/Transferase inhibitor
kinase
Transferase-Transferase inhibitor complex
TrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-(1-naphthyl)urea PDB:5KMM Structural characterization of nonactive site, TrkA-selective kinase inhibitors.
TRANSFERASE/TRANSFERASE INHIBITOR
kinase
juxtamembrane
inhibitor
TRANSFERASE-TRANSFERASE INHIBITOR complex
TrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea PDB:5KMN Structural characterization of nonactive site, TrkA-selective kinase inhibitors.
TRANSFERASE/TRANSFERASE INHIBITOR
kinase
juxtamembrane
inhibitor
TRANSFERASE-TRANSFERASE INHIBITOR complex
The structure of TrkA kinase bound to the inhibitor 1-cyclopropyl-1-[3-(1,3-thiazol-2-yl)benzyl]-3-[4-(trifluoromethoxy)phenyl]urea PDB:4PMP Maximizing diversity from a kinase screen: identification of novel and selective pan-Trk inhibitors for chronic pain.
Transferase/Transferase inhibitor
kinase
Transferase-Transferase inhibitor complex
Crystal structure of TrkA in complex with PF-05206283 PDB:5JFV The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
HYDROLASE/HYDROLASE INHIBITOR
TrkA inhibitor complex
HYDROLASE-HYDROLASE INHIBITOR complex
The structure of TrkA kinase bound to the inhibitor N-(3-cyclopropyl-1-phenyl-1H-pyrazol-5-yl)-2-{4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl}acetamide PDB:4PMM Maximizing diversity from a kinase screen: identification of novel and selective pan-Trk inhibitors for chronic pain.
Transferase/Transferase inhibitor
kinase
Transferase-Transferase inhibitor complex
Crystal structure of TrkA in complex with PF-00593174 PDB:5JFS The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
HYDROLASE/HYDROLASE INHIBITOR
TrkA inhibitor complex
HYDROLASE-HYDROLASE INHIBITOR complex
Crystal Structure of TrkA kinase with ligand PDB:5H3Q The juxtamembrane region of TrkA kinase is critical for inhibitor selectivity
TRANSFERASE/TRANSFERASE INHIBITOR
TrkA inhibitor
TRANSFERASE-TRANSFERASE INHIBITOR complex
TrkA JM-kinase with 1-(9{H}-fluoren-9-yl)-3-(2-methyl-4-phenyl-pyrimidin-5-yl)urea PDB:5KMI Structural characterization of nonactive site, TrkA-selective kinase inhibitors.
TRANSFERASE/TRANSFERASE INHIBITOR
kinase
juxtamembrane
inhibitor
TRANSFERASE-TRANSFERASE INHIBITOR complex
Crystal structure of TrkA in complex with PF-05247452 PDB:5JFW The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
HYDROLASE/HYDROLASE INHIBITOR
TrkA inhibitor complex
HYDROLASE-HYDROLASE INHIBITOR complex