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Displaying 3 of 3 results for "NFE2L2"
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Title Date Issued Date Released Description
Data from: Molecular evolution of the nuclear factor (erythroid-derived 2)-like 2 gene Nrf2 in Old World fruit bats (Chiroptera: Pteropodidae)
01-06-2016 01-06-2016
Mammals developed antioxidant systems to defend against oxidative damage in their daily life. Enzymatic antioxidants and low molecular weight antioxidants (LMWAs) constitute major parts of the antioxidant systems. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2, encoded by the Nrf2 gene) is a central transcriptional regulator, regulating transcription, of many antioxidant enzymes. Frugivorous bats eat large amounts of fruits that contain high levels of LMWAs such as vitamin C, thus, a reliance on LMWAs might greatly reduce the need for antioxidant enzymes in comparison to insectivorous bats. Therefore, it is possible that frugivorous bats have a reduced need for Nrf2 function due to their substantial intake of diet-antioxidants. To test whether the Nrf2 gene has undergone relaxed evolution in fruit-eating bats, we obtained Nrf2 sequences from 16 species of bats, including four Old World fruit bats (Pteropodidae) and one New World fruit bat (Phyllostomidae). Our molecular evolutionary analyses revealed changes in the selection pressure acting on Nrf2 gene and identified seven specific amino acid substitutions that occurred on the ancestral lineage leading to Old World fruit bats. Biochemical experiments were conducted to examine Nrf2 in Old World fruit bats and showed that the amount of catalase, which is regulated by Nrf2, was significantly lower in the brain, heart and liver of Old World fruit bats despite higher levels of Nrf2 protein in Old World fruit bats. Computational predictions suggest that three of these seven amino acid replacements might be deleterious to Nrf2 function. Therefore, the results suggest that Nrf2 gene might have experienced relaxed constraint in Old World fruit bats, however, we cannot rule out the possibility of positive selection. Our study provides the first data on the molecular adaptation of Nrf2 gene in frugivorous bats in compensation to the increased levels of LWMAs from their fruit-diet.
Unconstrained Nrf2 Bayesian phylogenetic tree and Nrf2 coding sequences
01-06-2016 01-06-2016
This is an NEXUS file,which including the Nrf2 coding sequences from 21 mammals and a unconstrained Nrf2 Bayesian phylogenetic tree. A Bayesian phylogenetic tree was reconstructed based on the aligned Nrf2 nucleotide sequences using MrBayes 3.1.2. Values on the nodes are posterior probabilities.The branch length information is also included. Nrf2 coding sequence from 21 species used in this study, including 16 chiropteran species and 5 other mammals.The species we used in this study are listed as follow. Cynopterus sphinx, Rousettus leschenaultia, Pteropus vampyus, Pteropus alecto, Artibeus jamaicensis, Pteronotus parnelli, Myotis ricketti, Myotis brandtti, Myotis davidii, Myotis lucifugus, Pipistrellus abramus, Hipposideros pratti, Rhinolophus pusillus, Megaderma lyra, Megaderma spasma, Taphozous melanopogon, Homo sapiens, Pan troglodytes, Canis familiaris, Bos taurus, Ictidomys tridecemlineatus.
Unconstrained Nrf2 Bayesian phylogenetic tree and species tree
01-06-2016 01-06-2016
This is a TIFF picture of Unconstrained Nrf2 Bayesian phylogenetic tree and species tree.