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Displaying 20 of 117 results for "MDM2"
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Dataset Title Dataset ID Primary Publications Keywords
Human MDM2 liganded with a 12mer peptide inhibitor (pDIQ) PDB:3JZS Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
S
LIGASE P53-BINDING PROTEIN MDM2 ONCOPROTEIN MDM2 DOUBLE MINUTE 2 PROTEIN HDM2 Ligase Proto-oncogene
Human MDM2 liganded with a 12mer peptide inhibitor (pDI6W) PDB:3JZR Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
S
LIGASE P53-BINDING PROTEIN MDM2 ONCOPROTEIN MDM2 DOUBLE MINUTE 2 PROTEIN HDM2 Ligase Proto-oncogene
Crystal structure of human MDM2 with a 12-mer peptide inhibitor PMI (N8A mutant) PDB:3LNZ Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions.
S
LIGASE/LIGASE INHIBITOR P53-BINDING PROTEIN of MDM2 ONCOPROTEIN MDM2 HUMAN DOUBLE MINUTE 2 PROTEIN H...
Structure of human MDM2 in complex with high affinity peptide PDB:3G03 High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx
H
Mdm2 Hdm2 Ligase Proto-oncogene
SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2 PDB:2C6A Solution Structure of the C4 Zinc Finger Domain of Hdm2.
S
LIGASE HUMAN MDM2 LIGASE NUCLEAR PROTEIN PROTO- ONCOGENE
SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2 PDB:2C6B Solution Structure of the C4 Zinc Finger Domain of Hdm2.
S
LIGASE HUMAN MDM2 LIGASE NUCLEAR PROTEIN PROTO- ONCOGENE
Structure of human MDM2 protein in complex with a small molecule inhibitor PDB:3LBK Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery
S
Ligase MDM2 Ligase Proto-oncogene
CRYSTAL STRUCTURE OF THE MDM2-MDMX RING DOMAIN HETERODIMER PDB:2VJE Structure of the Mdm2/Mdmx Ring Domain Heterodimer Reveals Dimerization is Required for Their Ubiquitylation in Trans.
S
LIGASE PROTO-ONCOGENE LIGASE
CRYSTAL STRUCTURE OF THE MDM2-MDMX RING DOMAIN HETERODIMER PDB:2VJF Structure of the Mdm2/Mdmx Ring Domain Heterodimer Reveals Dimerization is Required for Their Ubiquitylation in Trans.
S
LIGASE PROTO-ONCOGENE LIGASE
crystal structure of MDM2 with chromenotriazolopyrimidine 1 PDB:3JZK Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction.
D
LIGASE MDM2 Ligase Proto-oncogene
Crystal structure of human MDM2 in complex with D-peptide inhibitor (DPMI-alpha) PDB:3LNJ A left-handed solution to peptide inhibition of the p53-MDM2 interaction.
A
LIGASE/LIGASE INHIBITOR MDM2 D-peptide activator of MDM2 MDM2-D-peptide complex Ligase Proto-oncogen...
Crystal structure of human MDM2 in complex with a 12-mer peptide inhibitor PDB:3EQS Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
S
Ligase MDM2 MDM2-peptide inhibitor complex Ligase Proto-oncogene
Crystal structure of human MDM2 complexed with D-peptide (12 residues) PDB:3IWY D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms.
D
LIGASE/LIGASE INHIBITOR MDM2 Ligase Proto-oncogene LIGASE-LIGASE INHIBITOR COMPLEX
Structure of human MDM2 protein in complex with Mi-63-analog PDB:3LBL Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery
S
Ligase MDM2 Ligase Proto-oncogene
NMR Structure of Mdm2 (6-125) with Pip-1 PDB:2LZG Ordering of the N-Terminus of Human MDM2 by Small Molecule Inhibitors.
O
PROTEIN BINDING Mdm2 oncogene protein-inhibitor complex PROTEIN BINDING
Crystal structure of human MDM2 in complex with a potent miniature protein inhibitor (18-residues) PDB:3IUX Apamin as a template for structure-based rational design of potent peptide activators of p53.
LIGASE MDM2 Ligase Proto-oncogene
Novel Spiro[3H-indole-3,2 -pyrrolidin]-2(1H)-one Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) IN COMPLEX WITH COMPOUND 6b PDB:5LAV Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction.
D
LIGASE MDM2 HDM2 Ligase
Novel Spiro[3H-indole-3,2 -pyrrolidin]-2(1H)-one Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) IN COMPLEX WITH COMPOUND BI-0252 PDB:5LAZ Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction.
D
LIGASE MDM2 HDM2 LIGASE
Novel Spiro[3H-indole-3,2 -pyrrolidin]-2(1H)-one Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) IN COMPLEX WITH COMPOUND 14 PDB:5LAW Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction.
D
LIGASE MDM2 HDM2 ligase
Discovery of New Natural-product-inspired Spiro-oxindole Compounds as Orally Active Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) IN COMPLEX WITH COMPOUND 6g PDB:5LAY Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction.
D
LIGASE MDM2 HDM2 LIGASE