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Dataset Title Dataset ID Primary Publications Keywords
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in complex with an inhibitor and MgATP PDB:3VVH X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in complex with an inhibitor and MgATP
X
kinase domain kinase
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP PDB:3EQB 2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase).
2
PROTEIN KINASE STRUCTURE MITOGEN ACTIVATED PROTEIN KINASE KINASE TERNARY CO-COMPLEX WITH KINASE NON-...
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP PDB:3DY7 Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?
B
dual specificity protein kinase non-ATP-competitive kinase inhibitor inhibitor-bound protein kinase ...
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with compound 1, ATP-GS AND MG2P PDB:3EQC Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
C
MEK1 KINASE Kinase Serine/threonine-protein kinase Tyrosine-protein kinase
Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) PDB:3W8Q Structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in "DFG-Asp Out" conformation
S
TRANSFERASE
TRANSFERASE
Nucleotide-binding
Phosphorylation
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP PDB:3E8N RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer.
R
PROTEIN KINASE-LIGAND-MGATP COMPLEX MEK1 MEK1-RDEA119 complex Kinase Serine/threonine-protein kinase...
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with ADP and MG2P PDB:3EQI Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
C
MEK1 KINASE Kinase Serine/threonine-protein kinase Tyrosine-protein kinase
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with K252A and MG2P PDB:3EQF Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
C
MEK1 KINASE Kinase Serine/threonine-protein kinase Tyrosine-protein kinase
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with PD, ADP AND MG2P PDB:3EQG Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
C
MEK1 KINASE Kinase Serine/threonine-protein kinase Tyrosine-protein kinase
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with U0126, ADP and MG2P PDB:3EQH Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
C
MEK1 KINASE Kinase Serine/threonine-protein kinase Tyrosine-protein kinase
Crystal Structure of the human mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgADP PDB:3MBL Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors.
S
Kinase inhibitor
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with ATP-GS and MG2P PDB:3EQD Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors.
C
MEK1 KINASE Kinase Serine/threonine-protein kinase Tyrosine-protein kinase
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP PDB:2P55 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.
4
protein kinase structure; Mitogen activated protein kinase kinase; signal transduction; ligand co-co...
Crystal Structure of the Human Mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgATP PDB:3PP1 Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer.
D
Kinase domain Kinase
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP PDB:1S9J Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.
S
PROTEIN KINASE-LIGAND-MgATP COMPLEX PROTEIN-PROTEIN INTERACTIONS
MEK1 with PF-04622664 Bound PDB:3DV3 Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?
B
Kinase Kinase inhibitors MEK Serine/threonine-protein kinase Tyrosine-protein kinase
Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4987655 and MgAMP-PNP PDB:3ORN Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent.
D
kinase kinase inhibitor mitogen-activated protein kinase kinase
Human MEK1 kinase in complex with CH5126766 and MgAMP-PNP PDB:3WIG Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors
D
kinase kinase inhibitor
MEK1 IN COMPLEX WITH BI 847325 PDB:5EYM Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases.
P
KINASE
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MAP KINASE KINASE 1 (MEK1) IN COMPLEX WITH A SMALL MOLECULE INHIBITOR AND ADP PDB:4ARK Optimization of Allosteric Mek Inhibitors - Part 1: Venturing Into Unexplored Sar Territories
O
KINASE