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Displaying 20 of 73 results for "JAK3"
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Dataset Title Dataset ID Primary Publications Keywords
JAK3 with covalent inhibitor PF-06651600 PDB:5TOZ Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition.
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JAK3 covalent kinase
Crystal structure of JAK3 kinase domain in complex with an indazole substituted pyrrolopyrazine PDB:3ZC6 Strategic Use of Conformational Bias and Structure Based Design to Identify Potent Jak3 Inhibitors with Improved Selectivity Against the Jak Family and the Kinome.
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ATP SITE KINASE INHIBITOR
JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-1-methyl-2-oxo-2-piperidin-1-yl-ethyl)-amide PDB:4HVI 3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models.
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Kinase-Inhibitor Complex
JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-2-hydroxy-1,2-dimethyl-propyl)-amide PDB:4HVG 3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models.
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Kinase-Inhibitor Complex
Crystal structure of JAK3 kinase domain in complex with a pyrrolopyridazine carboxamide inhibitor PDB:4RIO Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors.
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TRANSFERASE/INHIBITOR
TRANSFERASE
TRANSFERASE-INHIBITOR complex
JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-2-hydroxy-1,2-dimethyl-propyl PDB:4HVH 3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models.
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Kinase-Inhibitor Complex
JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-1,2,2-trimethyl-propyl)-amide PDB:4HVD 3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models.
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Kinase-Inhibitor Complex
Crystal structure of JAK3 complexed with a potent ATP site inhibitor showing high selectivity within the Janus kinase family PDB:3PJC Identification of a Potent Janus Kinase 3 Inhibitor with High Selectivity within the Janus Kinase Family.
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ATP site kinase inhibitor
Discovery of VX-509 (Decernotinib): A Potent and Selective Janus kinase (JAK) 3 Inhibitor for the Treatment of Autoimmune Disease PDB:4YTI Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases.
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janus kinase jak3 kinase
Jak3 with covalent inhibitor 7 PDB:5TTU Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.
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kinase
Crystal structure of JAK3 in complex with Compound 4 (FM381) PDB:5LWM Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket.
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Kinase JAK3
Discovery of VX-509 (Decernotinib): A Potent and Selective Janus kinase (JAK) 3 Inhibitor for the Treatment of Autoimmune Diseases PDB:4YTH Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases.
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jak3 kinase jak2 kinase
Crystal structure of JAK3 in complex with Compound 5 (FM409) PDB:5LWN Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket.
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JAK3
JAK3 kinase domain in complex with 2-Phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-1-cyclopropyl-ethyl)-amide PDB:4I6Q Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors.
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Kinase-Inhibitor Complex
Jak3 with covalent inhibitor 4 PDB:5TTS Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.
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kinase
Jak3 with covalent inhibitor 6 PDB:5TTV Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.
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kinase
Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6 PDB:3LXK Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.
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JAK3 Kinase Tyrosine-protein kinase
Crystal structure of the Jak3 kinase domain in complex with a staurosporine analogue PDB:1YVJ Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog
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TYROSINE KINASE; SCID; SEVERE COMBINED IMMUNODEFICIENCY; STAT5; STAT6; INTERLEUKIN-2; COMMON-GAMMA C...
Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6 PDB:3LXL Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.
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JAK3 Kinase Tyrosine-protein kinase
CRYSTAL STRUCTURE OF JAK3 KINASE DOMAIN IN COMPLEX WITH A PYRROLOPYRIDAZINE INHIBITOR PDB:5VO6 Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors.
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TRANSFERASE/INHIBITOR
TRANSFERASE
TRANSFERASE-INHIBITOR COMPLEX