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Dataset Title Dataset ID Primary Publications Keywords
pVHL54-213-EloB-EloC complex_apo PDB:3ZRF Targeting the Von Hippel-Lindau E3 Ubiquitin Ligase Using Small Molecules to Disrupt the Vhl/Hif-1Alpha Interaction
TRANSCRIPTION
TRANSCRIPTION
TUMOUR SUPRESSOR PROTEIN
CHRONIC ANEAMIA TREATMENT
E3 UBIQUITIN LIGASE
pVHL54-213-EloB-EloC complex_(2S,4R)-4-hydroxy-1-(2-(3-methylisoxazol- 5-yl)acetyl)-N-(4-nitrobenzyl)pyrrolidine-2-carboxamide bound PDB:3ZUN Elongin-B, Elongin-C, Von Hippel-Lindau Disease Tumor Suppressor Complex
TRANSCRIPTION
TRANSCRIPTION
TUMOUR SUPRESSOR PROTEIN
PVHL E3 UBIQUITIN LIGASE
Crystal structure of the Vif-CBFbeta-CUL5-ElOB-ElOC pentameric complex PDB:4N9F Structural basis for hijacking CBF-b and CUL5 E3 ligase complex by HIV-1 Vif
LIGASE/VIRAL PROTEIN
Zinc Finger motif
stabilize VIf interaction with CUL5
CUL5
TRANSCRIPTION-VIRAL PROTEIN complex
LIGASE-VIRAL PROTEIN complex
pVHL54-213-EloB-EloC complex (4R)-4-HYDROXY-1-[(3-METHYLISOXAZOL-5-YL)ACETYL]-N-[4-(1,3-OXAZOL-5-YL)BENZYL]-L-PROLINAMIDE bound PDB:3ZRC Targeting the Von Hippel-Lindau E3 Ubiquitin Ligase Using Small Molecules to Disrupt the Vhl/Hif-1Alpha Interaction
TRANSCRIPTION
TRANSCRIPTION
TUMOUR SUPRESSOR PROTEIN
CHRONIC ANEAMIA TRE E3 TREATMENT
E3 UBIQUITIN LIGASE
pVHL54-213-EloB-EloC complex _ (2S,4R)-N-((1,1'-biphenyl)-4-ylmethyl)- 4-hydroxy-1-(2-(3-methylisoxazol-5-yl)acetyl)pyrrolidine-2- carboxamide PDB:3ZTC Dissecting Fragment-Based Lead Discovery at the Von Hippel-Lindau Protein:Hypoxia Inducible Factor 1Alpha Protein-Protein Interface.
TRANSCRIPTION
TRANSCRIPTION
TUMOUR SUPRESSOR PROTEIN
CHRONIC ANEAMIA TREATMENT
E3 UBIQUITIN LIGASE
pVHL54-213-EloB-EloC complex _ methyl 4-(((2S,4R)-4-hydroxy-1-(2-(3- methylisoxazol-5-yl)acetyl)pyrrolidine-2-carboxamido)methyl)benzoate PDB:3ZTD Dissecting Fragment-Based Lead Discovery at the Von Hippel-Lindau Protein:Hypoxia Inducible Factor 1Alpha Protein-Protein Interface.
TRANSCRIPTION
TRANSCRIPTION
TUMOUR SUPRESSOR PROTEIN
PVHL E3 UBIQUITIN LIGASE
Structure of VHL-EloB-EloC-Cul2 PDB:4WQO Insights into Cullin-RING E3 Ubiquitin Ligase Recruitment: Structure of the VHL-EloBC-Cul2 Complex.
TRANSCRIPTION
E3 ligase complex
TRANSCRIPTION
pVHL-ELOB-ELOC complex_(2S,4R)-1-(3-amino-2-methylbenzoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide bound PDB:4B9K Small-Molecule Inhibitors of the Interaction between the E3 Ligase Vhl and Hif1 Alpha
LIGASE
LIGASE
INHIBITOR
pVHL-EloB-EloC complex_(2S,4R)-1-(2-chlorophenyl)carbonyl-N-[(4-chlorophenyl)methyl]-4-oxidanyl-pyrrolidine-2-carboxamide bound PDB:4B95 Small-Molecule Inhibitors of the Interaction between the E3 Ligase Vhl and Hif1Alpha
TRANSCRIPTION
TRANSCRIPTION
HYPOXIA INDUCIBLE FACTOR
HIF-1ALPHA INHIBITOR
Crystal structure of the Cul2-Rbx1-EloBC-VHL ubiquitin ligase complex PDB:5N4W Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.
LIGASE
Cullin RING
E3 ubiquitin ligase
VHL
ligase
Cullin-2