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Displaying 20 of 156 results for "DGCR2"
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Dataset Title Dataset ID Primary Publications Keywords
Human aldose reductase mutant S302R complexed with IDD 393. PDB:2PDP Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features.
OXIDOREDUCTASE
TIM barrel
OXIDOREDUCTASE
Complex of Aldose Reductase with inhibitor IDD 1219 PDB:4GCA Complex of Aldose Reductase with inhibitor IDD 1219
C
OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
OXIDOREDUCTASE
TIM BARREL
OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Human Aldose Reductase mutant T113A complexed with IDD 594 PDB:3LQL Tracing the detail: how mutations affect binding modes and thermodynamic signatures of closely related aldose reductase inhibitors
OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
T113A mutant
oxidoreductase
TIM barrel
NADP
Phosphoprotein
OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Human Aldose Reductase complexed with a ligand with an IDD structure (2) at 1.07 A. PDB:4YS1 Aldose Reductase: IDD ligands under investigation
A
OXIDOREDUCTASE
Tim Barrel
Oxidoreductase
Inhibitor
Complex
Human Aldose Reductase complexed with a ligand with an IDD structure at 1.20 A (1) PDB:4RPQ Aldose Reductase: IDD ligands under investigation
A
oxidoreductase/oxidoreductase inhibitor
TIM BARREL
oxidoreductase-oxidoreductase inhibitor complex
Human Aldose Reductase complexed with a ligand with an IDD structure ([2-(benzylcarbamoyl)-5-fluorophenoxy]acetic acid) at 1.19 A PDB:4Q7B Aldose Reductase: How expensive is the opening of the specificity pocket? IDD ligands under investigation
A
oxidoreductase/oxidoreductase inhibitor
TIM BARREL
OXIDOREDUCTASE
oxidoreductase-oxidoreductase inhibitor complex
Human Aldose Reductase complexed with a ligand with an IDD structure (2-[2-(1,3-benzothiazol-2-ylmethylcarbamoyl)-5-fluoro-phenoxy]acetic acid) at 1.05 A PDB:4QR6 Aldose Reductase: How expensive is the opening of the specificity pocket? IDD ligands under investigation
A
oxidoreductase/oxidoreductase inhibitor
TIM BARREL
oxidoreductase-oxidoreductase inhibitor complex
Human Aldose Reductase complexed with a ligand with an IDD structure (2-[5-fluoro-2-(prop-2-ynylcarbamoyl)phenoxy]acetic acid) at 1.12 A PDB:4PUW Aldose Reductase: How expensive is the opening of the specificity pocket? IDD ligands under investigation
A
Oxidoreductase/Oxidoreductase inhibitor
Tim Barrel
Oxidoreductase-Oxidoreductase inhibitor complex
Human Aldose Reductase complexed with a ligand with an IDD structure (2-(2-carbamoyl-5-fluoro-phenoxy)acetic acid) at 1.14 A PDB:4PUU Human Aldose Reductase: How expensive is the opening of the specificity pocket? IDD ligands under investigation
H
Oxidoreductase/Oxidoreductase inhibitor
Tim Barrel
Oxidoreductase
Oxidoreductase-Oxidoreductase inhibitor complex
Human Aldose Reductase complexed with a ligand with an IDD structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid) at 0.98 A PDB:4QBX Aldose Reductase: How expensive is the opening of the specificity pocket? IDD ligands under investigation
A
oxidoreductase/oxidoreductase inhibitor
TIM BARREL
OXIDOREDUCTASE
oxidoreductase-oxidoreductase inhibitor complex
Human aldose reductase in complex with a nitrile-containing IDD inhibitor PDB:3T42 Electrostatic Fields near the Active Site of Human Aldose Reductase: 2. New Inhibitors and Complications Caused by Hydrogen Bonds.
E
oxidoreductase/oxidoreductase inhibitor
Tim Barrel
oxidoreductase-oxidoreductase inhibitor complex
Human aldose reductase complexed with IDD 740 inhibitor PDB:3G5E Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.
D
OXIDOREDUCTASE
ALDOSE REDUCTASE
INHIBITION
DIABETES
Cataract
NADP
Oxidoreductase
Phosphoprotein
Human aldose reductase complexed with halogenated IDD-type inhibitor PDB:2IKI Structural and Thermodynamic Study on Aldose Reductase: Nitro-substituted Inhibitors with Strong Enthalpic Binding Contribution
OXIDOREDUCTASE
TIM barrel
OXIDOREDUCTASE
Human aldose reductase complexed with nitro-substituted IDD-type inhibitor PDB:2IKJ Structural and Thermodynamic Study on Aldose Reductase: Nitro-substituted Inhibitors with Strong Enthalpic Binding Contribution
OXIDOREDUCTASE
TIM barrel
OXIDOREDUCTASE
Three-dimensional EM structure of an intact activator-dependent transcription initiation complex PDB:3IYD Three-dimensional EM structure of an intact activator-dependent transcription initiation complex
TRANSCRIPTION/DNA
transcription
initiation
Class I
activator
RNA polymerase
holoenzyme
sigma70
open complex
CAP
CRP
cAMP-dependent
DNA
prokaryotic
DNA-directed RNA polymerase
Nucleotidyltransferase
Transferase
DNA-binding
Sigma factor
Transcription regulation
cAMP
cAMP-binding
Nucleotide-binding
TRANSCRIPTION-DNA COMPLEX
E. coli expressome PDB:5MY1 TBA
RIBOSOME
expressome ribosome RNA polymerase
ribosome
Crystal structure of E. coli RNA polymerase alpha subunit C-terminal domain PDB:3K4G Structure of the Escherichia coli RNA polymerase alpha subunit C-terminal domain.
S
TRANSFERASE
BACTERIAL TRANSCRIPTION REGULATION
DNA-directed RNA polymerase
Nucleotidyltransferase
Transcription
Transferase
X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with Guanosine tetraphosphate (ppGpp) PDB:4JK1 Differential regulation by ppGpp versus pppGpp in Escherichia coli.
TRANSCRIPTION
TRANSFERASE
transcription
DNA
TRANSFERASE
Pim1 Complexed with a pyridylcarboxamide PDB:4N6Z Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.
TRANSFERASE/TRANSFERASE INHIBITOR
kinase
phosphorylation
TRANSFERASE-TRANSFERASE INHIBITOR complex
The complex structure of JMJD2A and trimethylated H3K36 peptide PDB:2P5B Structural basis of the recognition of a methylated histone tail by JMJD2A.
METAL BINDING PROTEIN METAL BINDING PROTEIN