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Dataset Title Dataset ID Primary Publications Keywords
Fragment-Based Screening of the Bromodomain of ATAD2 PDB:4TZ2 Fragment-Based Screening of the Bromodomain of ATAD2.
F
ATAD2
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with thymine PDB:4QSU Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
S
SIGNALING PROTEIN
Structural Genomics Consortium (SGC)
SIGNALING PROTEIN
bromodomain
actyl-lysine binding
ATPase family AAA domain-containing protein 2
epigenetics
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with N-Methyl-2-pyrrolidone (NMP) PDB:4QSS Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
S
SIGNALING PROTEIN
Structural Genomics Consortium (SGC)
SIGNALING PROTEIN
bromodomain
actyl-lysine binding
ATPase family AAA domain-containing protein 2
epigenetics
Fragment-Based Screening of the Bromodomain of ATAD2 PDB:4TYL Fragment-Based Screening of the Bromodomain of ATAD2.
F
Hydrolase/Hydrolase inhibitor
Bromodomain
Hydrolase-Hydrolase inhibitor complex
Structure of human ATAD2 bromodomain bound to fragment inhibitor PDB:4TZ8 Fragment-Based Screening of the Bromodomain of ATAD2.
F
ATAD2
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with 5-methyl uridine PDB:4QSW Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
S
SIGNALING PROTEIN
Structural Genomics Consortium (SGC)
SIGNALING PROTEIN
bromodomain
actyl-lysine binding
ATPase family AAA domain-containing protein 2
epigenetics
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) with bound DMSO PDB:4QSQ Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
S
SIGNALING PROTEIN
Structural Genomics Consortium (SGC)
SIGNALING PROTEIN
bromodomain
actyl-lysine binding
ATPase family AAA domain-containing protein 2
epigenetics
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with 3'-deoxy thymidine PDB:4QSX Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
S
SIGNALING PROTEIN
Structural Genomics Consortium (SGC)
SIGNALING PROTEIN
bromodomain
actyl-lysine binding
ATPase family AAA domain-containing protein 2
epigenetics
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with 1-methylquinolin 2-one PDB:4QST Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
S
SIGNALING PROTEIN
Structural Genomics Consortium (SGC)
SIGNALING PROTEIN
bromodomain
actyl-lysine binding
ATPase family AAA domain-containing protein 2
epigenetics
Crystal structure of human ATAD2 bromodomain in complex with 8-(3R,4R) -3-(cyclohexylmethoxy)piperidin-4-yl-amino-3-methyl-1,2-dihydro-1,7- naphthyridin-2-one PDB:5A81 Structure-Based Optimization of Naphthyridones Into Potent Atad2 Bromodomain Inhibitors.
S
ATAD2
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) with bound MPD PDB:4QSR Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
S
SIGNALING PROTEIN
Structural Genomics Consortium (SGC)
SIGNALING PROTEIN
bromodomain
actyl-lysine binding
ATPase family AAA domain-containing protein 2
epigenetics
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with acetyl-lysine PDB:4QSP Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
S
SIGNALING PROTEIN
Structural Genomics Consortium (SGC)
SIGNALING PROTEIN
bromodomain
actyl-lysine binding
ATPase family AAA domain-containing protein 2
epigenetics
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with thymidine PDB:4QSV Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
S
SIGNALING PROTEIN
Structural Genomics Consortium (SGC)
SIGNALING PROTEIN
bromodomain
actyl-lysine binding
ATPase family AAA domain-containing protein 2
epigenetics
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) complexed with Histone H4-K(ac)12 PDB:4QUT Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells.
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SIGNALING PROTEIN
Structural Genomics
Structural Genomics Consortium
SGC
SIGNALING PROTEIN
bromodomain
actyl-lysine binding
ATPase family AAA domain-containing protein 2
epigenetics
histone
bromodomain-histone
Structural Genomics Consortium (SGC)
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) complexed with Histone H4-K(ac)5 PDB:4QUU Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells.
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SIGNALING PROTEIN
Structural Genomics
Structural Genomics Consortium
SGC
SIGNALING PROTEIN
bromodomain
actyl-lysine binding
ATPase family AAA domain-containing protein 2
epigenetics
histone
bromodomain-histone
Structural Genomics Consortium (SGC)
Crystal structure of human ATAD2 bromodomain in complex with 8-(((3R,4R,5S)-3-((4,4-difluorocyclohexyl)methoxy)-5-methoxypiperidin-4-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one PDB:5LJ0 A Chemical Probe for the ATAD2 Bromodomain.
A
ATAD2
Crystal structure of the bromodomain of the human ATAD2 PDB:3DAI Histone recognition and large-scale structural analysis of the human bromodomain family.
SIGNALING PROTEIN
ATPase family
AAA domain containing 2
ANCCA
AAA+ nuclear coregulator cancer-associated PRO2000 protein
two AAA domain containing protein
SGC
Structural Genomics Consortium
ATP-binding
Bromodomain
Nucleotide-binding
Phosphoprotein
SIGNALING PROTEIN
Crystal structure of the bromodomain of human ATAD2 in complex with Compound A14 PDB:5F3A Crystal structure of the bromodomain of human ATAD2 in complex with Compound A14
C
TRANSFERASE
HYDROLASE INHIBITOR Complex
TRANSFERASE
Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49 PDB:5EPB Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49
C
TRANSFERASE
HYDROLASE INHIBITOR Complex
TRANSFERASE
Crystal structure of human ATAD2 bromodomain in complex with 3-methyl- 1,2-dihydroquinolin-2-one PDB:5A5O Fragment-Based Discovery of Low-Micromolar Atad2 Bromodomain Inhibitors.
F
ATAD2