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Displaying 20 of 131,204 results for " "
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Dataset Title Dataset ID Primary Publications Keywords
I-II linker of TRPML1 channel at pH 4.5 PDB:5TJB Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel.
TRANSPORT PROTEIN
endolysosomal lumen
tetramer
calcium and pH regulation
TRANSPORT PROTEIN
Structure of WWP2 WW2-2,3-linker-HECT aa 334-398 linked to 485-865 PDB:5TJ7 A Tunable Brake for HECT Ubiquitin Ligases.
TRANSFERASE
WWP2
HECT Domain
WW2
WWP1
ITCH
autoinhibition
TRANSFERASE
Structure of chicken CD1-2 with bound fatty acid PDB:3DBX The crystal structure of avian CD1 reveals a smaller, more primordial antigen-binding pocket compared to mammalian CD1
IMMUNE SYSTEM
CD1
evolution
antigen-presentation
MHC-fold
hydrophobic binding groove
Immunoglobulin domain
Membrane
Transmembrane
Disease mutation
Glycation
Glycoprotein
Immune response
MHC I
Pyrrolidone carboxylic acid
Secreted
IMMUNE SYSTEM
Structure of human DNA polymerase beta Host-Guest complex with the dG base paired with a dA PDB:5DBB N7 Methylation Alters Hydrogen-Bonding Patterns of Guanine in Duplex DNA.
transferase/dna
human dna polymerase
transferase-dna complex
ETHYLBENZENE DEHYDROGENASE FROM AROMATOLEUM AROMATICUM PDB:2IVF Crystal Structure of Ethylbenzene Dehydrogenase from Aromatoleum Aromaticum
OXIDOREDUCTASE
ANAEROBIC HYDROCARBON DEGRADATION
MOCO
FE/S CLUSTER
MO- BISMGD ENZYME
DMSO REDUCTASE FAMILY
OXIDOREDUCTASE
STRUCTURE OF UP1 PROTEIN PDB:2IVN An Archaeal Orthologue of the Universal Protein Kae1 is an Iron Metalloprotein which Exhibits Atypical DNA-Binding Properties and Apurinic-Endonuclease Activity in Vitro.
HYDROLASE
UP1 KEOPS COMPLEX
FE/ZN DEPENDENT NUCLEOTIDE PHOSPHATASE
METALLOPROTEASE
HYPOTHETICAL PROTEIN
PROTEASE
HYDROLASE
METAL-BINDING
Crystal structure of tRNA (Um34/Cm34) methyltransferase TrmL from Escherichia coli with SAH PDB:4JAL The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL
TRANSFERASE
SPOUT
methyltransferase
tRNA modification
TrmL
deep trefoil knot
SAM binding
methylation
TRANSFERASE
Structure of the Flavoprotein Tryptophan-2-Monooxygenase PDB:4IV9 Structure of the flavoprotein tryptophan 2-monooxygenase, a key enzyme in the formation of galls in plants.
OXIDOREDUCTASE
FAD cofactor
monoamine oxidase family
oxidative decarboxylation
flavoenzyme
indole-3-acetamide
OXIDOREDUCTASE
CRYSTAL STRUCTURE OF A TRANSCRIPTIONAL REGULATOR PDB:2IVM Mechanistic Insights from the Crystal Structures of a Feast/Famine Regulatory Protein from Mycobacterium Tuberculosis H37Rv.
TRANSCRIPTION
TRANSCRIPTIONAL REGULATOR
TRANSCRIPTION
CPD lesion containing RNA Polymerase II elongation complex D PDB:2JA8 Cpd Damage Recognition by Transcribing RNA Polymerase II.
TRANSFERASE
DNA-DIRECTED RNA POLYMERASE
LESION RECOGNITION
TRANSFERASE/DNA/RNA
DNA DAMAGE
ZINC-FINGER
DNA-BINDING
PHOTOLESION
PHOSPHORYLATION
MISINCORPORATION
RNA POLYMERASE II
TRANSCRIPTION-COUPLED REPAIR
CYCLOBUTANE PYRIMIDINE DIMER TCR
CPD
ARREST
STALLING
DNA LESION
METAL-BINDING
NUCLEAR PROTEIN
TRANSCRIPTION BUBBLE
NUCLEOTIDYLTRANSFERASE
DAMAGE RECOGNITION
ELONGATION COMPLEX
TRANSFERASE
THYMINE DIMER
TRANSCRIPTION
Crystal structure of the HigB2 toxin in complex with Nb2 PDB:5JA8 Ribosome-dependent Vibrio cholerae mRNAse HigB2 is regulated by a beta-strand sliding mechanism.
TOXIN
toxin-antitoxin system
toxin
Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase PDB:1IV1 Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.
LYASE
isoprenoid
non-mevalonate
synthase
RIKEN Structural Genomics/Proteomics Initiative
RSGI
Structural Genomics
LYASE
Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones PDB:4JAP Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones.
TRANSFERASE
lipid biosynthesis
Structural Genomics
Enzyme Function Initiative
ketosynthase enzyme
Alkylpyrone synthesis
TRANSFERASE
Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Constrained WAY-derivative, 5b PDB:4IV4 Ligand binding dynamics rewire cellular signaling via Estrogen Receptor-alpha
TRANSCRIPTION
Nuclear hormone receptor
Transcription factor
Ligand-binding
Nucleus
TRANSCRIPTION
Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered Through X-Ray Fragment Screening PDB:5JAU Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
HYDROLASE
phospholipase
lipid metabolism
hydrolase
LeuT T354H mutant in the outward-oriented, Na+-free Return State PDB:5JAG A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state.
TRANSPORT PROTEIN
NSS family
apo state
transport protein
Cryo-EM structure of GDP-microtubule co-polymerized with EB3 PDB:3JAR Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins.
STRUCTURAL PROTEIN
microtubule
EB3
GDP
STRUCTURAL PROTEIN
CRYSTAL STRUCTURE OF D12N VARIANT OF MOUSE CYTOSOLIC 5'(3')-DEOXYRIBONUCLEOTIDASE (CDN) IN COMPLEX WITH DEOXYGUANOSINE 5'-MONOPHOSPHATE PDB:2JAO Crystal Structures of Human and Murine Deoxyribonucleotidases: Insights Into Recognition of Substrates and Nucleotide Analogues.
HYDROLASE
NUCLEOTIDE METABOLISM
NUCLEOTIDE-BINDING
ALPHA-BETA FOLD
METAL-BINDING
HYDROLASE
MAGNESIUM
CYTOSOL
STRUCTURAL DETERMINATION OF THE A50T:S279G:S280K:V281K:K282E:H283N VARIANT OF CITRATE SYNTHASE FROM E. COLI COMPLEXED with NADH PDB:4JAF Enzyme-substrate complexes of allosteric citrate synthase: Evidence for a novel intermediate in substrate binding.
TRANSFERASE
CITRATE SYNTHASE
GRAM-NEGATIVE BACTERIA
ALLOSTERY
OXALOACETATE
ACETYL-COA
NADH
PROTEIN FOLDING
S-CARBOXYMETHYL-COA
ALLOSTERIC ENZYME
TRANSFERASE
TRICARBOXYLIC ACID CYCLE
Structure of a partial yeast 48S preinitiation complex in open conformation PDB:3JAQ Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex.
TRANSLATION
Eukaryotic translation initiation
48S
small ribosome subunit
40S
43S
TRANSLATION