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Title: A core circuit, formed by a subset of regulatory interactions involving five global transcription factors (FIS, HNS, IHF, RpoS and GadX), has been identified by correlating information from the well- established transcriptional regulatory network of Escherichia coli and genome-wide expression data from cultures in these different growth phases. We propose a functional role for this circuit in controlling progression through these phases. Two alternative hypotheses for controlling the transition between the growth phases are first, a continuous graded adjustment to changing environmental conditions, and second, a discontinuous hysteretic switch at critical thresholds between growth phases. We formulate a simple mathematical model of the core circuit, consisting of differential equations based on the power-law formalism, and show by mathematical and computerassisted analysis that there are critical conditions among the parameters of the model that can lead to hysteretic switch behavior, which if validated experimentally would suggest that the transitions between different growth phases might be analogous to cellular differentiation. Based on these provocative results, we propose experiments to test the alternative hypotheses.      
dateReleased:
12-31-2014
privacy:
information not avaiable
aggregation:
instance of dataset
dateCreated:
12-31-2014
refinement:
curated
ID:
doi:10.6084/M9.FIGSHARE.1282460
availability:
available
types:
other
accessURL: https://doi.org/10.6084/M9.FIGSHARE.1282460
storedIn:
Figshare
qualifier:
not compressed
format:
HTML
accessType:
landing page
authentication:
none
authorization:
none
abbreviation:
figshare
homePage: http://figshare.com/
ID:
SCR:004328
name:
figshare