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Title: A Practical, Ligand-Free, Palladium-Catalyzed Isocyanide Insertion Reaction for the Construction of Novel Ring-Fused Quinazolinones      
dateReleased:
04-22-2015
privacy:
information not avaiable
aggregation:
instance of dataset
dateCreated:
08-01-2013
refinement:
curated
ID:
doi:10.4125/PD0046TH
creators:
Ji, Fei
Lv, Mei-Fang
Yi, Wen-Bin
Cai, Chun
availability:
available
types:
other
description:
A high-yielding, ligand-free, palladium-catalyzed isocyanide insertion reaction for the synthesis of phthalazino[1,2-b]quinazolinones from the readily obtainable quinazolinones has been developed. Easily handled and relatively low-cost palladium(II) acetate was used as the catalyst, without an additional ligand. Preparation of the quinazolinones involved the cascade reaction of isatoic anhydrides, phenylhydrazines and 2-bromobenzaldehyde catalyzed by p-toluenesulfonic acid in one pot. This novel protocol may be applicable for the synthesis of other important ring-fused heterocyclic compounds.
accessURL: https://doi.org/10.4125/PD0046TH
storedIn:
© Georg Thieme Verlag
qualifier:
not compressed
format:
HTML
accessType:
landing page
authentication:
none
authorization:
none
abbreviation:
Thieme Chemistry
homePage: https://www.thieme.de/
ID:
SCR:SCR_014699
name:
Thieme Chemistry

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