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Title: Synthesis of Sterically Hindered Chiral 1,4-Diols from Different Lignan-Based Backbones      
dateReleased:
04-22-2015
privacy:
information not avaiable
aggregation:
instance of dataset
dateCreated:
02-05-2014
refinement:
curated
ID:
doi:10.4125/PD0051TH
creators:
Brusentsev, Yury
Hänninen, Mikko
Eklund, Patrik
availability:
available
types:
other
description:
Methods for synthetic modifications of the natural dibenzylbutyrolactone lignan hydroxymatairesinol into chiral 1,4-diols with different lignan-derived backbones have been developed. A stepwise procedure, involving alkylation and oxidation, was shown to be successful and several highly substituted 1,4-diols were prepared. Some substituted butyrolactones resisted alkylation and led to the formation unusually stable hemiketals (butyrolactols). The formation of stable hemiketals was investigated in detail, showing that different backbone structures influence the formation and reactivity of the hemiketals.
accessURL: https://doi.org/10.4125/PD0051TH
storedIn:
© Georg Thieme Verlag
qualifier:
not compressed
format:
HTML
accessType:
landing page
authentication:
none
authorization:
none
abbreviation:
Thieme Chemistry
homePage: https://www.thieme.de/
ID:
SCR:SCR_014699
name:
Thieme Chemistry

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