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Title: Copper-Catalyzed C–N Cross-Coupling of Substituted 2-Halobenzoates with Secondary Acyclic Amides      
dateReleased:
04-27-2015
privacy:
information not avaiable
aggregation:
instance of dataset
dateCreated:
04-27-2015
refinement:
curated
ID:
doi:10.4125/PD0047TH
creators:
Wang, Man-Gang
Yu, Hua
Wu, Jun
Shang, Zhi-Cai
availability:
available
types:
other
description:
The copper-catalyzed C–N cross-coupling of poorly nucleophilic acyclic secondary amides with sterically hindered substituted 2-halobenzoates has been demonstrated with 1,4-dimethyl-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one (DMBDO) as ligands for the first time. The protocol is effective for the synthesis of hindered tertiary amides. We also found that the alkoxycarbonyl (CO2R) group has a strong ortho-substituent effect on a Goldberg-type C–N coupling reaction.
accessURL: https://doi.org/10.4125/PD0047TH
storedIn:
© Georg Thieme Verlag
qualifier:
not compressed
format:
HTML
accessType:
landing page
authentication:
none
authorization:
none
abbreviation:
Thieme Chemistry
homePage: https://www.thieme.de/
ID:
SCR:SCR_014699
name:
Thieme Chemistry

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