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Title: Whole Exome Sequencing of Chronic Lymphocytic Leukemia      
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available
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refinement:
curated
ID:
phs000435.v1.p1
description:

The somatic genetic basis of chronic lymphocytic leukemia (CLL), a common and clinically heterogenous adult leukemia, remains poorly understood. Massively parallel sequencing technology now provides a method for systematic discovery of genetic alterations that underlie disease, and for uncovering new therapeutic targets and biomarkers. We present a dataset consisting of DNA sequencing from 91 CLL samples (with matched germline controls). Samples were collected from patients displaying a wide range of characteristics representing the broad clinical spectrum of CLL.

Understanding the mutational landscape of CLL provides a starting point for systematic analyses to address fundamental questions in CLL, including how mutated genes alter cellular networks and phenotypes, and thereby contribute to disease heterogeneity.

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true
accessURL: https://www.ebi.ac.uk/ega/studies/phs000435.v1.p1
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JSON
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OmicsDI
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download
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accessURL: www.omicsdi.org/ws/dataset/arrayexpress-repository/phs000435.v1.p1.json
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XML
storedIn:
OmicsDI
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accessType:
download
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accessURL: http://www.omicsdi.org/ws/dataset/arrayexpress-repository/phs000435.v1.p1.xml
ID:
SCR:014747
name:
Omics Discovery Index
abbreviation:
OmicsDI
homePage: http://www.omicsdi.org/