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Title: Probing the protein inventory of the human pathogen Clostridium difficile      
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available
aggregation:
instance of dataset
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not applicable
refinement:
curated
dateReleased:
01-01-1000
ID:
PXD003659
description:
The anaerobic and spore-forming bacterium Clostridium difficile has turned into an intensively studied species which can be attributed to increasing numbers of infections and rising costs for the health care system. This dataset represents a benchmark proteome of reference strain C. difficile 630erm and provides mass spectrometry based details on identified proteins which was generally missing from hitherto published datasets. An elaborate annotation and visualization of the 3764 open reading frames will serve as a valuable base for researchers trying to evaluate results of global expression studies. Furthermore, protein expression of late exponentially growing cells in the complex medium BHI and in C. difficile minimal medium was compared. Whereas abundance of proteins of DNA metabolism, protein synthesis and cell envelope showed no variation, enzymes for the biosynthesis of some vitamins and purine as well as proteins involved in butanoate fermentation differed significantly depending on the growth medium.
keywords:
comprehensive peptide library
Clostridium difficile
benchmark proteome
label-free protein quantification
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primary:
true
accessURL: http://www.ebi.ac.uk/pride/archive/projects/PXD003659
format:
JSON
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OmicsDI
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accessType:
download
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accessURL: www.omicsdi.org/ws/dataset/arrayexpress-repository/PXD003659.json
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XML
storedIn:
OmicsDI
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accessType:
download
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primary:
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accessURL: http://www.omicsdi.org/ws/dataset/arrayexpress-repository/PXD003659.xml
ID:
SCR:014747
name:
Omics Discovery Index
abbreviation:
OmicsDI
homePage: http://www.omicsdi.org/