Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Title: VIF_HV1N5      
description:
Virion infectivity factor Virion infectivity factor p17 Virion infectivity factor p7 Interaction with host APOBEC3F; F1-box Interaction with host APOBEC3G; G-box Interaction with host APOBEC3F and APOBEC3G; FG-box Interaction with host APOBEC3F; F2-box RNA-binding Multimerization Membrane association HCCH motif BC-box-like motif Cleavage in virion (by viral protease) Phosphothreonine; by host MAP4K1 Phosphoserine; by host Phosphoserine; by host MAP4K1 Phosphothreonine; by host In strain: Clinical isolate; from an asymptomatic patient; Vif is mislocalized to the nucleus and non functional. 44% loss of viral infectivity No effect on viral infectivity 29% loss of viral infectivity 14% loss of viral infectivity 59% loss of viral infectivity 35% loss of viral infectivity 94% loss of viral infectivity 95% loss of viral infectivity 39% loss of viral infectivity 45% loss of viral infectivity 97% loss of viral infectivity No effect onviral infectivity 19% loss of viral infectivity 42% loss of viral infectivity No effect on viral infectivity 27% loss of viral infectivity 98% loss of viral infectivity Complete loss of interaction with CUL5 93% loss of viral infectivity 98% loss of viral infectivity. Complete loss of interaction with CUL5 35% increase of viral infectivity 10% loss of viral infectivity 95% loss of viral infectivity. Complete loss of interaction with CUL5 73% loss of viral infectivity Complete loss of interaction with CUL5 68% loss of viral infectivity 93% loss of viral infectivity 25% loss of interaction with CUL5y Complete loss of interaction with CUL5 90% loss of interaction with CUL5 40% loss of viral infectivity 40% loss of interaction with CUL5 35% loss of interaction with CUL5 Complete loss of processing between p17 and p7. Complete loss of replication 75% loss of CUL5 binding activity 90% loss of CUL5 binding activity No effect on processing between p17 and p7 Slightly increased processing between p17 and p7 Increased processing between p17 and p7 Partial loss of processing between p17 and p7 No effect on viral infectivity No effect viral infectivity 9% loss of viral infectivity 33% loss of viral infectivity 88% loss of viral infectivity 97% loss of viral infectivity 27% loss of viral infectivity No effect viral infectivity 26% loss of viral infectivity 63% loss of viral infectivity 67% loss of viral infectivity 20% loss of viral infectivity 42% loss of viral infectivity 5% loss of viral infectivity 4% loss of viral infectivity
types:
sequence
dateReleased:
10-01-1989
ID:
P12504
privacy:
not applicable
keywords:
3D-structure
AIDS
Direct protein sequencing
Host cell membrane
Host cytoplasm
Host membrane
Host-virus interaction
Membrane
Phosphoprotein
RNA-binding
Ubl conjugation
Ubl conjugation pathway
Virion
availability:
available
refinement:
curated
version:
1
aggregation:
instance of dataset
name:
Human immunodeficiency virus type 1 group M subtype B
strain:
isolate NY5
ID:
ncbitax:11698
name:
Virion infectivity factor
name:
vif
authorization:
none
authentication:
none
format:
HTML
storedIn:
UniProt
accessType:
landing page
qualifier:
not compressed
accessURL: http://www.uniprot.org/uniprot/P12504
license:
Creative Commons Attribution-NoDerivs License
authorization:
none
authentication:
none
format:
FASTA
storedIn:
UniProt
accessType:
download
qualifier:
not compressed
accessURL: http://www.uniprot.org/uniprot/P12504.fasta
license:
Creative Commons Attribution-NoDerivs License
name:
European Bioinformatics Institute
abbreviation:
EMBL-EBI
ID:
SCR:004727
homePage: http://www.ebi.ac.uk/
name:
UniProt
abbreviation:
UniProt
ID:
SCR:002380
homePage: http://www.uniprot.org/

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on GitHub.