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Title: GAG_HV1H2      
description:
Removed; by host Gag polyprotein Matrix protein p17 Capsid protein p24 Spacer peptide 1 Nucleocapsid protein p7 Spacer peptide 2 p6-gag CCHC-type 1 CCHC-type 2 Interaction with Gp41 Interaction with host CALM1 Interaction with host AP3D1 Interaction with membrane phosphatidylinositol 4,5-bisphosphate and RNA Interaction with membrane phosphatidylinositol 4,5-bisphosphate Interaction with host PPIA/CYPA and NUP153 PPIA/CYPA-binding loop Dimerization/Multimerization of capsid protein p24 Nuclear export signal Nuclear localization signal PTAP/PSAP motif LYPX(n)L motif Cleavage; by viral protease Cleavage; by viral protease Cleavage; by viral protease Cleavage; by viral protease Cleavage; by viral protease Phosphoserine; by host MAPK1 Asymmetric dimethylarginine; in Nucleocapsid protein p7; by host PRMT6 Asymmetric dimethylarginine; in Nucleocapsid protein p7; by host PRMT6 N-myristoyl glycine; by host No influence on the PIP2- or concentration-dependent myristyl switch mechanism No influence on the PIP2- or concentration-dependent myristyl switch mechanism Replication-defective, induces nuclear mislocalization of matrix protein; when associated with G-22 Replication-defective, induces nuclear mislocalization of matrix protein; when associated with A-18 No effect on subcellular localization of matrix protein; when associated with A-18 and G-22 No influence on the PIP2- or concentration-dependent myristyl switch mechanism No influence on the PIP2- or concentration-dependent myristyl switch mechanism 3-fold decrease of PPIA-binding affinity 2.7-fold decrease of PPIA-binding affinity 8-fold decrease of PPIA-binding affinity 44-fold decrease of PPIA-binding affinity 3.4-fold decrease of PPIA-binding affinity 31-fold decrease of PPIA-binding affinity 154-fold decrease of PPIA-binding affinity 36-fold decrease of PPIA-binding affinity More than 150-fold decrease of PPIA-binding affinity 1.2-fold decrease of PPIA-binding affinity 1.0-fold decrease of PPIA-binding affinity 2.3-fold decrease of PPIA-binding affinity 1.7-fold decrease of PPIA-binding affinity 1.6-fold decrease of PPIA-binding affinity Decreases infectivity and replication Complete loss of infectivity and in vitro chaperone activity Complete loss of infectivity and DNA synthesis Partial loss of infectivity. Complete loss of in vitro chaperone activity Partial loss of infectivity
types:
sequence
dateReleased:
01-23-2007
ID:
P04591
privacy:
not applicable
keywords:
3D-structure
AIDS
Capsid protein
Complete proteome
Host cell membrane
Host cytoplasm
Host endosome
Host membrane
Host nucleus
Host-virus interaction
Lipoprotein
Membrane
Metal-binding
Methylation
Myristate
Phosphoprotein
Reference proteome
Repeat
Ribosomal frameshifting
RNA-binding
Viral budding
Viral budding via the host ESCRT complexes
Viral nucleoprotein
Virion
Virus exit from host cell
Zinc
Zinc-finger
availability:
available
refinement:
curated
version:
3
aggregation:
instance of dataset
name:
Human immunodeficiency virus type 1 group M subtype B
strain:
isolate HXB2
ID:
ncbitax:11706
name:
Gag polyprotein
name:
gag
authorization:
none
authentication:
none
format:
HTML
storedIn:
UniProt
accessType:
landing page
qualifier:
not compressed
accessURL: http://www.uniprot.org/uniprot/P04591
license:
Creative Commons Attribution-NoDerivs License
authorization:
none
authentication:
none
format:
FASTA
storedIn:
UniProt
accessType:
download
qualifier:
not compressed
accessURL: http://www.uniprot.org/uniprot/P04591.fasta
license:
Creative Commons Attribution-NoDerivs License
name:
European Bioinformatics Institute
abbreviation:
EMBL-EBI
ID:
SCR:004727
homePage: http://www.ebi.ac.uk/
name:
UniProt
abbreviation:
UniProt
ID:
SCR:002380
homePage: http://www.uniprot.org/

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