Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Title: IRS1_HUMAN      
description:
Insulin receptor substrate 1 PH IRS-type PTB Mediates interaction with PHIP GRB2-binding YXXM motif 1 YXXM motif 2 YXXM motif 3 YXXM motif 4 YXXM motif 5 YXXM motif 6 YXXM motif 7 YXXM motif 8 YXXM motif 9 Poly-Gly Ser-rich Poly-Ser Poly-Ser Poly-Gln Pro-rich Phosphoserine Phosphoserine; by CK2 Phosphoserine; by RPS6KB1 Phosphoserine; by RPS6KB1 Phosphoserine; by IKKB, MAPK8 and RPS6KB1 Phosphoserine Phosphoserine Phosphoserine Phosphoserine Phosphoserine Phosphothreonine Phosphothreonine Phosphotyrosine; by INSR Phosphoserine; by RPS6KB1 Phosphotyrosine; by INSR Phosphoserine Phosphotyrosine; by INSR Phosphoserine; by RPS6KB1 Phosphotyrosine Phosphoserine; by AMPK and SIK2 Phosphoserine Phosphotyrosine; by INSR Phosphotyrosine; by INSR Phosphotyrosine; by INSR Phosphoserine Phosphoserine; by RPS6KB1 and PKC/PRKCQ Phosphotyrosine; by INSR Phosphotyrosine; by INSR In dbSNP:rs1801108. In dbSNP:rs1801118. In dbSNP:rs1801276. May contribute to insulin resistance by impairing metabolic signaling through PI3K-dependent pathways; dbSNP:rs104893642. In NIDDM. In dbSNP:rs1801120. In dbSNP:rs1801277. In dbSNP:rs1801278. In NIDDM. In NIDDM. In dbSNP:rs3731594. Impaired degradation by the Cul7-RING(FBXW8) complex; when associated with A-312; A-527; A-636 and A-639 Impaired degradation by the Cul7-RING(FBXW8) complex; when associated with A-307; A-527; A-636 and A-639 Impaired degradation by the Cul7-RING(FBXW8) complex; when associated with A-307; A-312; A-636 and A-639 Impaired degradation by the Cul7-RING(FBXW8) complex; when associated with A-307; A-312; A-527 and A-639 Impaired degradation by the Cul7-RING(FBXW8) complex; when associated with A-307; A-312; A-527 and A-636 Loss of phosphorylation by SIK2 (in Ref. 2; AAB21608) (in Ref. 2; AAB21608) (in Ref. 2; AAB21608)
types:
sequence
dateReleased:
06-01-1994
ID:
P35568
privacy:
not applicable
keywords:
3D-structure
Complete proteome
Diabetes mellitus
Disease mutation
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transducer
Ubl conjugation
availability:
available
refinement:
curated
version:
1
aggregation:
instance of dataset
name:
Homo sapiens
strain:
Human
ID:
ncbitax:9606
name:
Insulin receptor substrate 1
name:
IRS1
authorization:
none
authentication:
none
format:
HTML
storedIn:
UniProt
accessType:
landing page
qualifier:
not compressed
accessURL: http://www.uniprot.org/uniprot/P35568
license:
Creative Commons Attribution-NoDerivs License
authorization:
none
authentication:
none
format:
FASTA
storedIn:
UniProt
accessType:
download
qualifier:
not compressed
accessURL: http://www.uniprot.org/uniprot/P35568.fasta
license:
Creative Commons Attribution-NoDerivs License
name:
European Bioinformatics Institute
abbreviation:
EMBL-EBI
ID:
SCR:004727
homePage: http://www.ebi.ac.uk/
name:
UniProt
abbreviation:
UniProt
ID:
SCR:002380
homePage: http://www.uniprot.org/

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on GitHub.