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Title: Telemetric and Holter ECG Warehouse (THEW): Quinidine (AZCERT)      
dateReleased:
01-01-2000
description:
IDENTIFICATION : E-OTH-12-2365-019 The data from this study was conducted by Benton et al and published in 2000 (PDF). The study aimed at determining wether there is a gender-specific difference in the effect of quinidine on cardiac repolarization. Twelve women and 12 men received a single intravenous dose of quinidine gluconate (4 mg/kg), a single oral dose of quinidine sulfate (300 or 400mg) or placebo in a single-blind, randomized crossover trial. Total plasma and protein-free concentrations of quinidine and 3-hydroxyquinidine were measured in serum. The study confirmed a longer QT interval duration at baseline than men: (mean ± SD; 407 ± 7 versus 395 ± 9 ms, P < .05). The slope of the relationship between change in the QTc interval (ΔQTc) after intravenous quinidine from baseline to the serum concentration of quinidine was 44% greater for women than for men (mean ± SE; 42.2 ± 3.4 versus 29.3 ± 2.6 ms/μg per mL, P < .001). The study concluded that intravenously administered Quinidine causes greater QT prolongation in women than in men at equivalent serum concentrations. Therefore, the detected difference in QT between gender may contribute to the greater incidence of drug-induced torsades de pointes observed in women taking quinidine and has implications for other cardiac and noncardiac drugs that prolong the QTc interval.
privacy:
information not available
aggregation:
instance of dataset
availability:
THEW Data Use Agreements (see Thew website for details)
refinement:
raw
creators:
Robert E. Benton
ID:
handle:11614/1644
types:
image
ID:
doi:10.1067/mcp.2000.105761
fullName:
Robert E. Benton
email: WoosleyR@gunet.georgetown.edu
accessURL: http://thew-project.org/register_main.htm
accesstypes:
Landing Page
storedIn:
CardioVascular Research Grid
authentication:
none
authorization:
none
abbreviation:
JHU
homePage: http://www.jhu.edu/
ID:
SCR:010247
name:
Johns Hopkins University
abbreviation:
CVRG
homePage: http://www.cvrgrid.org/
ID:
SCR:004472
name:
CardioVascular Research Grid

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