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Title: Data from: The evolution of bat nucleic acid sensing Toll-like receptors      
keywords:
Molecular Evolution
Adaptation
Selection
Gene Structure and Function
nucleic acid-sensing Toll-like receptors
Bats
Molecular evolution
selection
type:
Article
description:
We characterized the nucleic acid sensing Toll-like receptors (TLR) of a New World bat species, the common vampire bat (Desmodus rotundus), and through a comparative molecular evolutionary approach searched for general adaptation patterns among the nucleic acid sensing TLRs of eight different bats species belonging to three families (Pteropodidae, Vespertilionidae and Phyllostomidae). We found that the bat TLRs are evolving slowly and mostly under purifying selection and that the divergence pattern of such receptors is overall congruent with the species tree, consistent with the evolution of many other mammalian nuclear genes. However, the chiropteran TLRs exhibited unique mutations fixed in ligand binding sites, some of which involved non-conservative amino acid changes and/or targets of positive selection. Such changes could potentially modify protein function and ligand biding properties, as some changes were predicted to alter nucleic acid binding motifs in TLR 9. Moreover, evidence for episodic diversifying selection acting specifically upon the bat lineage and sub lineages was detected. Thus, the long-term adaptation of chiropterans to a wide variety of environments and ecological niches with different pathogen profiles is likely to have shaped the evolution of the bat TLRs in an order-specific manner. The observed evolutionary patterns provide evidence for potential functional differences between bat and other mammalian TLRs in terms of resistance to specific pathogens or recognition of nucleic acids in general.
ID:
oai:datadryad.org:10255/dryad.99539
accesstypes:
download
landingPage: http://hdl.handle.net/10255/dryad.99539
authentication:
none
authorization:
none
ID:
doi:10.5061/dryad.dq1j6
Escalera-Zamudio M, Zepeda-Mendoza LM, Loza-Rubio E, Rojas-Anaya E, Méndez-Ojeda ML, Arias CF, Greenwood AD (2015) The evolution of bat nucleic acid sensing Toll-like receptors. Molecular Ecology 24(23): 5899–5909.
http://hdl.handle.net/10255/dryad.99539
MolEcol-MEC-15-0892.R1
setID:
hdl_10255_3
recNum:
6
setName:
Main
dateReleased:
02-26-2016
issueDate:
20151021
accessionDate:
10-21-2015
dateCreated:
10-21-2015
abbreviation:
Dryad
ID:
SCR:005910
name:
Dryad Digital Repository
homepage: http://www.datadryad.org
ID:
SCR:005910
name:
Dryad Data Repository

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