Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Title: Data from: Resource base influences genome-wide DNA methylation levels in wild baboons (Papio cynocephalus)      
keywords:
Ecological Genetics
Genomics/Proteomics
Mammals
Behavior/Social Evolution
type:
Article
description:
Variation in resource availability commonly exerts strong effects on fitness-related traits in wild animals. However, we know little about the molecular mechanisms that mediate these effects, or about their persistence over time. To address these questions, we profiled genome-wide whole blood DNA methylation levels in two sets of wild baboons: (i) ‘wild-feeding’ baboons that foraged naturally in a savanna environment and (ii) ‘Lodge’ baboons that had ready access to spatially concentrated human food scraps, resulting in high feeding efficiency and low daily travel distances. We identified 1,014 sites (0.20% of sites tested) that were differentially methylated between wild-feeding and Lodge baboons, providing the first evidence that resource availability shapes the epigenome in a wild mammal. Differentially methylated sites tended to occur in contiguous stretches (i.e., in differentially methylated regions or DMRs), in promoters and enhancers, and near metabolism-related genes, supporting their functional importance in gene regulation. In agreement, reporter assay experiments confirmed that methylation at the largest identified DMR, located in the promoter of a key glycolysis-related gene, was sufficient to causally drive changes in gene expression. Intriguingly, all dispersing males carried a consistent epigenetic signature of their membership in a wild-feeding group, regardless of whether males dispersed into or out of this group as adults. Together, our findings support a role for DNA methylation in mediating ecological effects on phenotypic traits in the wild, and emphasize the dynamic environmental sensitivity of DNA methylation levels across the life course.
ID:
oai:datadryad.org:10255/dryad.99283
accesstypes:
download
landingPage: http://hdl.handle.net/10255/dryad.99283
authentication:
none
authorization:
none
ID:
doi:10.5061/dryad.2d80m
Lea AJ, Altmann J, Alberts SC, Tung J (2016) Resource base influences genome-wide DNA methylation levels in wild baboons (Papio cynocephalus). Molecular Ecology 25(8): 1681–1696.
http://hdl.handle.net/10255/dryad.99283
MolEcol-MEC-15-0877.R1
setID:
hdl_10255_3
recNum:
14
setName:
Main
dateReleased:
09-27-2016
issueDate:
20151028
accessionDate:
10-28-2015
dateCreated:
10-28-2015
abbreviation:
Dryad
ID:
SCR:005910
name:
Dryad Digital Repository
homepage: http://www.datadryad.org
ID:
SCR:005910
name:
Dryad Data Repository

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on GitHub.