Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Title: Data from: Analysis of VEGFA variants and changes in VEGF levels underscores the contribution of VEGF to polycystic ovary syndrome      
keywords:
Polycystic ovary syndrome
Vascular endothelial growth factor
type:
Article
description:
Background. Vascular endothelial growth factor (VEGF) contributes to the pathogenesis of polycystic ovary syndrome (PCOS), and genetic variations in VEGFA gene were suggested to contribute to VEGF secretion and PCOS. Aim. To evaluate the association of altered VEGF levels, stemming from the presence of specific VEGFA variants, with altered risk of PCOS. Subjects and Methods. Retrospective case-control study, performed between 2012-2015. Study subjects comprised 382 women with PCOS, and 393 control subjects. ELISA measured VEGF levels; genotyping of VEGFA variants was done by allelic exclusion. Results. Among the 12 tested VEGFA SNPs, minor allele frequency of only rs3025020 was significantly higher in PCOS cases than control women. Increased and reduced PCOS risk was seen with rs3025020 and rs2010963 genotypes, respectively. Increases and reduction in VEGF levels were associated with rs3025020 and rs2010963, respectively. Increased fasting insulin and HOMA-IR, and bioactive testosterone were linked with rs3025020, while carriage of rs2010963 was linked with reduction in fasting insulin, and free and bioactive testosterone. Of the 12 VEGFA variants, 9 were in LD, thus allowing construction of 9-locus haplotypes. Increased frequency of CAACAGCGA haplotype was seen in PCOS cases, after controlling for BMI, free and bioactive testosterone, SHBG, free insulin and HOMA-IR. Conclusion. This study confirms the contribution of altered VEGF secretion, resulting from genetic variation in VEGFA gene into the pathogenesis of PCOS. This supports a role for VEGF as PCOS candidate locus.
ID:
oai:datadryad.org:10255/dryad.123991
accesstypes:
download
landingPage: 1932-6203
authentication:
none
authorization:
none
ID:
doi:10.5061/dryad.nb1hc
Almawi WY, Gammoh E, Malalla ZH, Al-Madhi SA (2016) Analysis of VEGFA Variants and Changes in VEGF Levels Underscores the Contribution of VEGF to Polycystic Ovary Syndrome. PLOS ONE 11(11): e0165636.
1932-6203
http://hdl.handle.net/10255/dryad.123991
PONE-D-16-21089
setID:
hdl_10255_3
recNum:
71
setName:
Main
dateReleased:
11-23-2016
issueDate:
20161115
accessionDate:
11-23-2016
dateCreated:
11-23-2016
abbreviation:
Dryad
ID:
SCR:005910
name:
Dryad Digital Repository
homepage: http://www.datadryad.org
ID:
SCR:005910
name:
Dryad Data Repository

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on GitHub.