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Title: Data from: Characterization of human cortical gene expression in relation to glucose utilization.      
keywords:
Brain Development
Brain Evolution
Microarray
Energy Metabolism
Energetics
type:
Article
description:
Objectives: Human brain development follows a unique pattern characterized by a prolonged period of postnatal growth and reorganization, and a postnatal peak in glucose utilization. The molecular processes underlying these developmental changes are poorly characterized. The objectives of this study were to determine developmental trajectories of gene expression and to examine the evolutionary history of genes differentially expressed as a function of age. Methods: We used microarrays to determine age-related patterns of mRNA expression in human cerebral cortical samples ranging from infancy to adulthood. In contrast to previous developmental gene expression studies of human neocortex that relied on postmortem tissue, we measured mRNA expression from the nondiseased margins of surgically resected tissue. We used regression models designed to identify transcripts that followed significant linear or curvilinear functions of age and used population genetics techniques to examine the evolution of these genes. Results: We identified 40 transcripts with significant age-related trajectories in expression. Ten genes have documented roles in nervous system development and energy metabolism, others are novel candidates in brain development. Sixteen transcripts showed similar patterns of expression, characterized by decreasing expression during childhood. Comparative genomic analyses revealed that the regulatory regions of three genes have evidence of adaptive evolution in recent human evolution. Conclusions: These findings provide evidence that a subset of genes expressed in the human cerebral cortex broadly mirror developmental patterns of cortical glucose consumption. Whether there is a causal relationship between gene expression and glucose utilization remains to be determined.
ID:
oai:datadryad.org:10255/dryad.46982
accesstypes:
download
landingPage: http://hdl.handle.net/10255/dryad.46982
authentication:
none
authorization:
none
ID:
doi:10.5061/dryad.fj8dm
Sterner KN, McGowen MR, Chugani HT, Tarca AL, Sherwood CC, Hof PR, Kuzawa CW, Boddy AM, Raaum RL, Weckle A, Lipovich L, Grossman LI, Uddin M, Goodman M, Wildman DE. Characterization of human cortical gene expression in relation to glucose utilization (2013) American Journal of Human Biology 25(3): 418–430.
http://hdl.handle.net/10255/dryad.46982
setID:
hdl_10255_3
recNum:
88
setName:
Main
dateReleased:
01-26-2017
issueDate:
20130404
accessionDate:
04-08-2013
dateCreated:
04-08-2013
abbreviation:
Dryad
ID:
SCR:005910
name:
Dryad Digital Repository
homepage: http://www.datadryad.org
ID:
SCR:005910
name:
Dryad Data Repository

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