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Title: Age-associated Changes in the Respiratory Epithelial Response to Influenza Infection [biopsy]      
keywords:
Other
ID:
PRJNA353639
description:
This study evaluates how aging impacts the interaction between influenza viruses and human respiratory epithelial cells. Our results indicate that aging is associated with a decrease in the gene expression of key antiviral mediators, IFITM1 and MX1, and a decrease in the expression of MHC-I and TAP mRNA and proteins responsible for antigen processing and presentation. Importantly however epithelial cells from older individuals produce similar, and in some cases greater, levels of chemokines as compared with hNECs from younger individuals. Taken together a defect in antigen processing and presentation could result in impaired clearance of infected epithelial cells allowing them to continue to produce inflammatory cytokines and chemokines resulting in prolonged inflammation and perhaps increased severity of disease. Overall design: Nasal biopsies from young (N=6) and older (N=5) subjects were collected and expression profiled.
accesstypes:
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landingpage: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA353639
authentication:
none
authorization:
none
name:
Homo sapiens
ncbiID:
ncbitax:9606
abbreviation:
NCBI
homePage: http://www.ncbi.nlm.nih.gov
ID:
SCR:006472
name:
National Center for Biotechnology Information
homePage: http://www.ncbi.nlm.nih.gov/bioproject
ID:
SCR:004801
name:
NCBI BioProject

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